Acetadote

Allergic Rhinitis, Corneal Diseases, Sinusitis + 9 more
Treatment
8 Active Studies for Acetadote

What is Acetadote

AcetylcysteineThe Generic name of this drug
Treatment SummaryAcetylcysteine is a medication used to clear mucus from the lungs and to treat an overdose of acetaminophen. It has also been studied for other conditions, but the results have been mixed. Acetylcysteine was approved by the FDA in 1963.
Acetylcysteineis the brand name
image of different drug pills on a surface
Acetadote Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Acetylcysteine
Acetylcysteine
1989
41

Effectiveness

How Acetadote Affects PatientsAcetylcysteine is a medicine used to thin mucus and for treating overdoses of acetaminophen. It needs to be taken every 1-8 hours depending on the route of administration, and it is generally considered safe. Patients should be advised to mix the oral solution with cola to make it more palatable, and be made aware of the risk of an allergic reaction or upper gastrointestinal bleeding.
How Acetadote works in the bodyAcetylcysteine has a variety of effects that make it useful as a mucolytic. It can break down mucin molecules, which makes them less sticky and viscous. It can also reduce the amount of mucin secreted by the body. Acetylcysteine is a powerful antioxidant, which can help protect against cell damage. In cases of acetaminophen overdose, it can help bind toxic metabolites to reduce their damage to cells.

When to interrupt dosage

The proposed dose of Acetadote is contingent upon the identified condition, including Allergic Rhinitis, Airway secretion clearance therapy and Keratopathy. The measure of dosage depends on the administration technique (e.g. Inhalant or Injection, solution) specified in the following table.
Condition
Dosage
Administration
Corneal Diseases
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Sinusitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Rhinitis, Allergic
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Corneal Diseases
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Rhinitis, Vasomotor
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
acetaminophen
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Airway secretion clearance therapy
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Corneal Ulcer
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Allergic Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral
Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
, Oral; Respiratory (inhalation), Solution, Solution - Oral; Respiratory (inhalation), Respiratory (inhalation), Inhalant, Inhalant - Respiratory (inhalation), Intravenous, Injection, Injection - Intravenous, Injection, solution, Injection, solution - Intravenous, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Liquid - Intravenous, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Tablet, Capsule, Capsule - Oral, Capsule, extended release, Capsule, extended release - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Acetadote has 1 contraindication, thus it should not be utilized while encountering the afflictions outlined in the following table.Acetadote Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Acetylcysteine may interact with Pulse Frequency
There are 20 known major drug interactions with Acetadote.
Common Acetadote Drug Interactions
Drug Name
Risk Level
Description
Revefenacin
Major
Acetylcysteine may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Ambrisentan
Minor
The excretion of Ambrisentan can be decreased when combined with Acetylcysteine.
Asunaprevir
Minor
The excretion of Asunaprevir can be decreased when combined with Acetylcysteine.
Atorvastatin
Minor
The excretion of Atorvastatin can be decreased when combined with Acetylcysteine.
Atrasentan
Minor
The excretion of Atrasentan can be decreased when combined with Acetylcysteine.
Acetadote Toxicity & Overdose RiskThose who overdose on acetylcysteine may have symptoms such as vomiting, nausea, difficulty breathing, swelling around the eyes, and low blood pressure. Treatment includes providing supportive care and hemodialysis, which can remove some of the acetylcysteine from the bloodstream since it binds to proteins.

Acetadote Novel Uses: Which Conditions Have a Clinical Trial Featuring Acetadote?

48 active trials are currently being conducted to assess the capacity of Acetadote in treating Sinusitis, acute Rhinitis and Keratopathy.
Condition
Clinical Trials
Trial Phases
acetaminophen
1 Actively Recruiting
Phase 2
Corneal Ulcer
0 Actively Recruiting
Corneal Diseases
3 Actively Recruiting
Not Applicable, Phase 4
Corneal Diseases
0 Actively Recruiting
Rhinitis
0 Actively Recruiting
Rhinitis, Vasomotor
0 Actively Recruiting
Sinusitis
4 Actively Recruiting
Not Applicable, Phase 4
Rhinitis, Allergic
0 Actively Recruiting
Airway secretion clearance therapy
0 Actively Recruiting
Allergic Rhinitis
0 Actively Recruiting
Rhinitis
0 Actively Recruiting
Rhinitis
0 Actively Recruiting

Patient Q&A Section about acetadote

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is acetylcysteine treatment used for?

"Acetylcysteine inhalation is a treatment for people with lung conditions including asthma, emphysema, bronchitis, and cystic fibrosis. This treatment helps to relieve chest congestion due to thick or abnormal mucous secretions."

Answered by AI

When do you give Acetadote?

"If a patient presents for care more than 8 hours after ingesting acetaminophen, they should be administered acetylcysteine immediately, regardless of how much they reportedly ingested."

Answered by AI

What is Acetadote used for?

"Acetadote is an antidote that is used to prevent or reduce liver damage in patients who have recently ingested a large amount of acetaminophen or who have been taking it in large doses over a long period of time."

Answered by AI

What is the generic name for Acetadote?

"Acetylcysteine is a drug used to reduce mucus in patients who suffer from certain lung diseases. It costs an average of $27 for 30 mL of 20% intravenous solution."

Answered by AI

Clinical Trials for Acetadote

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