Acetadote

Allergic Rhinitis, Corneal Diseases, Sinusitis + 9 more

Treatment

5 Active Studies for Acetadote

What is Acetadote

Acetylcysteine

The Generic name of this drug

Treatment Summary

Acetylcysteine is a medication used to clear mucus from the lungs and to treat an overdose of acetaminophen. It has also been studied for other conditions, but the results have been mixed. Acetylcysteine was approved by the FDA in 1963.

Acetylcysteine

is the brand name

image of different drug pills on a surface

Acetadote Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Acetylcysteine

Acetylcysteine

1989

41

Effectiveness

How Acetadote Affects Patients

Acetylcysteine is a medicine used to thin mucus and for treating overdoses of acetaminophen. It needs to be taken every 1-8 hours depending on the route of administration, and it is generally considered safe. Patients should be advised to mix the oral solution with cola to make it more palatable, and be made aware of the risk of an allergic reaction or upper gastrointestinal bleeding.

How Acetadote works in the body

Acetylcysteine has a variety of effects that make it useful as a mucolytic. It can break down mucin molecules, which makes them less sticky and viscous. It can also reduce the amount of mucin secreted by the body. Acetylcysteine is a powerful antioxidant, which can help protect against cell damage. In cases of acetaminophen overdose, it can help bind toxic metabolites to reduce their damage to cells.

When to interrupt dosage

The proposed dose of Acetadote is contingent upon the identified condition, including Allergic Rhinitis, Airway secretion clearance therapy and Keratopathy. The measure of dosage depends on the administration technique (e.g. Inhalant or Injection, solution) specified in the following table.

Condition

Dosage

Administration

Corneal Diseases

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Sinusitis

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Rhinitis

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Rhinitis, Allergic

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Corneal Diseases

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Rhinitis, Vasomotor

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Rhinitis

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

acetaminophen

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Airway secretion clearance therapy

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Corneal Ulcer

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Allergic Rhinitis

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Rhinitis

, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg

Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Inhalant, Intravenous, Injection, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid, Oral, Tablet, effervescent, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet, Capsule - Oral, Capsule, extended release - Oral, Tablet - Oral, Tablet, coated - Oral, Tablet, coated, Liquid - Intravenous, Solution - Intravenous; Oral; Respiratory (inhalation), Capsule, Capsule, extended release

Warnings

Acetadote has 1 contraindication, thus it should not be utilized while encountering the afflictions outlined in the following table.

Acetadote Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Acetylcysteine may interact with Pulse Frequency

There are 20 known major drug interactions with Acetadote.

Common Acetadote Drug Interactions

Drug Name

Risk Level

Description

Revefenacin

Major

Acetylcysteine may decrease the excretion rate of Revefenacin which could result in a higher serum level.

Ambrisentan

Minor

The excretion of Ambrisentan can be decreased when combined with Acetylcysteine.

Asunaprevir

Minor

The excretion of Asunaprevir can be decreased when combined with Acetylcysteine.

Atorvastatin

Minor

The excretion of Atorvastatin can be decreased when combined with Acetylcysteine.

Atrasentan

Minor

The excretion of Atrasentan can be decreased when combined with Acetylcysteine.

Acetadote Toxicity & Overdose Risk

Those who overdose on acetylcysteine may have symptoms such as vomiting, nausea, difficulty breathing, swelling around the eyes, and low blood pressure. Treatment includes providing supportive care and hemodialysis, which can remove some of the acetylcysteine from the bloodstream since it binds to proteins.

Acetadote Novel Uses: Which Conditions Have a Clinical Trial Featuring Acetadote?

48 active trials are currently being conducted to assess the capacity of Acetadote in treating Sinusitis, acute Rhinitis and Keratopathy.

Condition

Clinical Trials

Trial Phases

acetaminophen

0 Actively Recruiting

Corneal Ulcer

0 Actively Recruiting

Corneal Diseases

2 Actively Recruiting

Not Applicable

Corneal Diseases

0 Actively Recruiting

Rhinitis

0 Actively Recruiting

Rhinitis, Vasomotor

1 Actively Recruiting

Not Applicable

Sinusitis

3 Actively Recruiting

Not Applicable

Airway secretion clearance therapy

0 Actively Recruiting

Rhinitis, Allergic

0 Actively Recruiting

Allergic Rhinitis

0 Actively Recruiting

Rhinitis

0 Actively Recruiting

Rhinitis

0 Actively Recruiting

Patient Q&A Section about acetadote

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is acetylcysteine treatment used for?

"Acetylcysteine inhalation is a treatment for people with lung conditions including asthma, emphysema, bronchitis, and cystic fibrosis. This treatment helps to relieve chest congestion due to thick or abnormal mucous secretions."

Answered by AI

When do you give Acetadote?

"If a patient presents for care more than 8 hours after ingesting acetaminophen, they should be administered acetylcysteine immediately, regardless of how much they reportedly ingested."

Answered by AI

What is Acetadote used for?

"Acetadote is an antidote that is used to prevent or reduce liver damage in patients who have recently ingested a large amount of acetaminophen or who have been taking it in large doses over a long period of time."

Answered by AI

What is the generic name for Acetadote?

"Acetylcysteine is a drug used to reduce mucus in patients who suffer from certain lung diseases. It costs an average of $27 for 30 mL of 20% intravenous solution."

Answered by AI

Clinical Trials for Acetadote

Image of Cedars-Sinai Medical Center Otolaryngology Clinics in Los Angeles, United States.

Lavender Aromatherapy for Anxiety and Pain During Otolaryngologic Procedures

18+
All Sexes
Los Angeles, CA

The purpose of this study is to evaluate the efficacy of lavender aromatherapy in adult patients undergoing awake otolaryngologic procedures in the outpatient clinic setting. The main questions it aims to answer are: * Does lavender aromatherapy help reduce anxiety and/or pain, and improve patient comfort during awake otolaryngologic procedures in the clinic? * Do patients subjectively find aromatherapy relaxing and/or beneficial during the procedure? Researchers will compare lavender aromatherapy to placebo (an odorless liquid) to see if lavender aromatherapy helps improve patient comfort during their awake procedure Participants will: * Have their scheduled procedure performed with lavender aromatherapy or placebo during the duration of the procedure * Take a short, less than 1 minute questionnaire both before and after the procedure, describing their levels of anxiety, pain and subjective impressions of the aromatherapy

Recruiting
Paid Trial

Cedars-Sinai Medical Center Otolaryngology Clinics

Ankona Ghosh, MD

Image of QHSLab in West Palm Beach, United States.

Digital Tools for Allergic Rhinitis

18 - 65
All Sexes
West Palm Beach, FL

This study aims to evaluate the effectiveness of digital tools in managing allergic rhinitis (AR) in primary care settings. AR is a common condition that affects many people's quality of life. The study will test whether digital tools, such as the QHSLab platform, can help patients better control their symptoms, improve adherence to treatment, and enhance overall well-being. The trial will compare two groups: one using standard care and the other using both standard care and digital tools. Participants will be monitored over 12 months, and the study will measure changes in symptom severity, treatment adherence, quality of life, and healthcare usage. The study will also gather feedback from patients and healthcare providers about their experience with the digital tools. The digital tools used in this study are designed to help patients manage their AR more effectively by providing regular symptom assessments, medication reminders, and personalized feedback based on their health data. This summary ensures the information is clear and straightforward for patients, families, and healthcare providers while maintaining compliance with IRB guidelines.

Waitlist Available
Has No Placebo

QHSLab

QHSLab, Inc.

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