Acetadote

Allergic Rhinitis, Corneal Diseases, Sinusitis + 9 more
Treatment
9 Active Studies for Acetadote

What is Acetadote

AcetylcysteineThe Generic name of this drug
Treatment SummaryAcetylcysteine is a medication used to clear mucus from the lungs and to treat an overdose of acetaminophen. It has also been studied for other conditions, but the results have been mixed. Acetylcysteine was approved by the FDA in 1963.
Acetylcysteineis the brand name
image of different drug pills on a surface
Acetadote Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Acetylcysteine
Acetylcysteine
1989
41

Effectiveness

How Acetadote Affects PatientsAcetylcysteine is a medicine used to thin mucus and for treating overdoses of acetaminophen. It needs to be taken every 1-8 hours depending on the route of administration, and it is generally considered safe. Patients should be advised to mix the oral solution with cola to make it more palatable, and be made aware of the risk of an allergic reaction or upper gastrointestinal bleeding.
How Acetadote works in the bodyAcetylcysteine has a variety of effects that make it useful as a mucolytic. It can break down mucin molecules, which makes them less sticky and viscous. It can also reduce the amount of mucin secreted by the body. Acetylcysteine is a powerful antioxidant, which can help protect against cell damage. In cases of acetaminophen overdose, it can help bind toxic metabolites to reduce their damage to cells.

When to interrupt dosage

The proposed dose of Acetadote is contingent upon the identified condition, including Allergic Rhinitis, Airway secretion clearance therapy and Keratopathy. The measure of dosage depends on the administration technique (e.g. Inhalant or Injection, solution) specified in the following table.
Condition
Dosage
Administration
Corneal Diseases
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Sinusitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Rhinitis, Allergic
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Corneal Diseases
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Rhinitis, Vasomotor
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
acetaminophen
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Airway secretion clearance therapy
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Corneal Ulcer
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Allergic Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release
Rhinitis
, 100.0 mg/mL, 200.0 mg/mL, 600.0 mg/mL, 500.0 mg, 2500.0 mg, 600.0 mg, 50.0 mg, 200.0 mg
Oral; Respiratory (inhalation), , Solution - Oral; Respiratory (inhalation), Solution, Respiratory (inhalation), Inhalant - Respiratory (inhalation), Injection, Intravenous, Injection - Intravenous, Injection, solution - Intravenous, Injection, solution, Liquid - Intravenous; Oral; Respiratory (inhalation), Liquid - Intravenous, Tablet, effervescent, Oral, Tablet, effervescent - Oral, Inhalant - Oral; Respiratory (inhalation), Tablet - Oral, Capsule - Oral, Capsule, extended release - Oral, Tablet, Tablet, coated - Oral, Tablet, coated, Liquid, Intravenous; Oral; Respiratory (inhalation), Solution - Intravenous; Oral; Respiratory (inhalation), Inhalant, Capsule, Capsule, extended release

Warnings

Acetadote has 1 contraindication, thus it should not be utilized while encountering the afflictions outlined in the following table.Acetadote Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Acetylcysteine may interact with Pulse Frequency
There are 20 known major drug interactions with Acetadote.
Common Acetadote Drug Interactions
Drug Name
Risk Level
Description
Revefenacin
Major
Acetylcysteine may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Ambrisentan
Minor
The excretion of Ambrisentan can be decreased when combined with Acetylcysteine.
Asunaprevir
Minor
The excretion of Asunaprevir can be decreased when combined with Acetylcysteine.
Atorvastatin
Minor
The excretion of Atorvastatin can be decreased when combined with Acetylcysteine.
Atrasentan
Minor
The excretion of Atrasentan can be decreased when combined with Acetylcysteine.
Acetadote Toxicity & Overdose RiskThose who overdose on acetylcysteine may have symptoms such as vomiting, nausea, difficulty breathing, swelling around the eyes, and low blood pressure. Treatment includes providing supportive care and hemodialysis, which can remove some of the acetylcysteine from the bloodstream since it binds to proteins.

Acetadote Novel Uses: Which Conditions Have a Clinical Trial Featuring Acetadote?

48 active trials are currently being conducted to assess the capacity of Acetadote in treating Sinusitis, acute Rhinitis and Keratopathy.
Condition
Clinical Trials
Trial Phases
acetaminophen
0 Actively Recruiting
Corneal Ulcer
0 Actively Recruiting
Corneal Diseases
1 Actively Recruiting
Not Applicable
Corneal Diseases
0 Actively Recruiting
Rhinitis
0 Actively Recruiting
Rhinitis, Vasomotor
0 Actively Recruiting
Sinusitis
2 Actively Recruiting
Not Applicable
Airway secretion clearance therapy
0 Actively Recruiting
Rhinitis, Allergic
0 Actively Recruiting
Allergic Rhinitis
0 Actively Recruiting
Rhinitis
0 Actively Recruiting
Rhinitis
0 Actively Recruiting

Patient Q&A Section about acetadote

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is acetylcysteine treatment used for?

"Acetylcysteine inhalation is a treatment for people with lung conditions including asthma, emphysema, bronchitis, and cystic fibrosis. This treatment helps to relieve chest congestion due to thick or abnormal mucous secretions."

Answered by AI

When do you give Acetadote?

"If a patient presents for care more than 8 hours after ingesting acetaminophen, they should be administered acetylcysteine immediately, regardless of how much they reportedly ingested."

Answered by AI

What is Acetadote used for?

"Acetadote is an antidote that is used to prevent or reduce liver damage in patients who have recently ingested a large amount of acetaminophen or who have been taking it in large doses over a long period of time."

Answered by AI

What is the generic name for Acetadote?

"Acetylcysteine is a drug used to reduce mucus in patients who suffer from certain lung diseases. It costs an average of $27 for 30 mL of 20% intravenous solution."

Answered by AI

Clinical Trials for Acetadote

Image of Columbia University Irving Medical Center in New York, United States.

Nanodropper-Mediated Anesthetic for Eye Conditions

18+
All Sexes
New York, NY
The goal of this clinical trial is to compare the onset and duration of numbness of the surface of the eye following the administration of numbing drops, called proparacaine, using either a standard eye drop bottle or a "Nanodropper" adaptor. The Nanodropper is designed to administer smaller-sized drops, or microdrops. Participants will: 1. Complete a baseline eye exam. 2. Receive a numbing drop using a standard dropper in one eye and the Nanodropper in the other eye. 3. Have their eyes tested for numbness at specific time points (30 seconds, 1, 2, 5, and 10 minutes after getting the drops). 4. Tell the researchers if they feel pain during the eye sensation tests. 5. Complete a survey about their experience with the eyedrops and testing procedure. This study could help us find a way to use less medication while still effectively administering eye medications, potentially saving money and reducing medical waste.
Phase 4
Recruiting
Columbia University Irving Medical Center
Image of QHSLab in West Palm Beach, United States.

Digital Tools for Allergic Rhinitis

18 - 65
All Sexes
West Palm Beach, FL
This study aims to evaluate the effectiveness of digital tools in managing allergic rhinitis (AR) in primary care settings. AR is a common condition that affects many people's quality of life. The study will test whether digital tools, such as the QHSLab platform, can help patients better control their symptoms, improve adherence to treatment, and enhance overall well-being. The trial will compare two groups: one using standard care and the other using both standard care and digital tools. Participants will be monitored over 12 months, and the study will measure changes in symptom severity, treatment adherence, quality of life, and healthcare usage. The study will also gather feedback from patients and healthcare providers about their experience with the digital tools. The digital tools used in this study are designed to help patients manage their AR more effectively by providing regular symptom assessments, medication reminders, and personalized feedback based on their health data. This summary ensures the information is clear and straightforward for patients, families, and healthcare providers while maintaining compliance with IRB guidelines.
Waitlist Available
Has No Placebo
QHSLabQHSLab, Inc.
Have you considered Acetadote clinical trials? We made a collection of clinical trials featuring Acetadote, we think they might fit your search criteria.Go to Trials
Image of University of Texas Medical Branch in Galveston, United States.

RG-RV for Cat Allergy

18 - 60
All Sexes
Galveston, TX
This is a mechanistic, controlled, open-label, single-site study to evaluate the effects of RG-RV16 inoculation on airway mucosal gene expression and airway remodeling in 25 healthy controls (HC), in 25 allergic rhinitis subjects (AR) with cat dander allergy, and in 25 allergic asthmatic subjects (AA) with cat dander allergy. Three groups (HC, AR, and AA) will undergo screening to establish clinical history, will undergo pulmonary function testing (spirometry), and will have blood drawn for clinical characterization (IgE, , ImmunoCAP, CBC and differential), and for assessing the presence of existing neutralizing antibody against RV16. Only those who meet criteria will be permitted to continue into the interventional and run-out phases of the study.
Phase 2
Recruiting
University of Texas Medical BranchWilliam J. Calhoun, MD
Image of Queen Elizabeth II Health Science Center in Halifax, Canada.

Intranasal Capsaicinoid Spray for Allergic Rhinitis

18+
All Sexes
Halifax, Canada
Rhinitis is inflammation of the inside of the nose. Symptoms of rhinitis include itchiness, sneezing, and a "runny" nose (rhinorrhea). There are many different causes for rhinitis, including allergies, age, different irritants in the air, overacting nervous system, and others. Many current treatments for rhinitis are not helpful or are unable to be used for long periods of time. Capsaicin ("Kap-Sey-Uh-Sin") is a natural product that is found in many spicy foods, including hot peppers. This natural product has been used as a lotion to prevent pain, and scientists have found that it may reduce the symptoms of rhinitis when used as a spray in the nose. However, capsaicin is known to cause a burning sensation. This study is needed so we can figure out what doses of capsaicin cause this burning sensation, and to what level these doses cause discomfort. Capsaicin can also cause a small degree of tearing from the eyes when used as a spray in the nose, and can also cause the nose to become "runny" (rhinorrhea). When the safest dose of capsaicin spray is found, that dose can be used to treat people with rhinitis that is not getting better from standard treatments.
Waitlist Available
Has No Placebo
Queen Elizabeth II Health Science CenterS Mark Taylor, MD FRCSC
Image of Vancouver General Hospital in Vancouver, Canada.

In-Clinic Endoscopic Polypectomy for Nasal Polyps

18+
All Sexes
Vancouver, Canada
Chronic rhinosinusitis, also called chronic sinusitis, is a very common life-long disease affecting over 5% of the Canadian population. Its symptoms, including daily facial pain and headache, an inability to breath through the nose and complete smell loss, regularly impair one's ability to work and to enjoy and participate in daily activities. The annual cost of chronic sinusitis to Canada is estimated at $1.3 billion while the government pays an estimated $860 million yearly for chronic sinusitis treatment. Chronic sinusitis with polyps, the most common type of chronic sinusitis, is usually treated with a combination of medications and surgery. Until now, surgical treatment has only been performed in the operating room, at a cost of about $3500 per procedure. But, recent studies have shown that a new procedure, "in-clinic polyp removal", can provide an improvement in patient symptoms to levels equal to those for sinus surgery performed in a hospital operating room. Moreover, in clinic polyp removal has additional advantages including a shorter procedure recovery time, a significantly lower cost to the health care system (about one-tenth the cost or $450), and a shorter wait time for treatment. With the proposed pragmatic trial, the investigators will determine whether the in clinic polyp removal procedure is as good as sinus surgery in the operating room at controlling patient symptoms of chronic sinusitis. The investigators will also determine the cost and health-benefits for a patient, the healthcare system and for society of in clinic polyp removal in comparison to sinus surgery done in a hospital operating room. The investigators will then know if this new treatment, in clinic polyp removal, can replace sinus surgery as the standard of care for these patients.
Recruiting
Has No Placebo
Vancouver General Hospital (+4 Sites)Shaun Kilty, MDMedtronic
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