What is Tilade
NedocromilThe Generic name of this drug
Treatment SummaryMontelukast is a medication that works to reduce inflammation in cells related to asthma, such as eosinophils, neutrophils, macrophages, mast cells, monocytes, and platelets. It does this by blocking the activation of these cells.
Tiladeis the brand name
Tilade Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Tilade
Nedocromil
1992
3
Effectiveness
How Tilade Affects PatientsNedocromil is a medicine that helps to reduce inflammation in the bronchial airways. It has been shown to decrease symptoms of asthma when triggered by allergens, and can also help to reduce sensitivity in the airways.
How Tilade works in the bodyNedocromil works to reduce inflammation associated with asthma by blocking the release of inflammatory substances like histamine, prostaglandin D2, and leukotrienes c4. It does this by inhibiting the activation of different types of cells in the bronchial tree. Nedocromil also works to block nerve reflexes and the release of sensory neuropeptides, like substance P and neurokinin A, which can cause bronchoconstriction. It does not have any effect on bronchodilators, antihistamines, or corticosteroids.
When to interrupt dosage
The proposed dosage of Tilade is contingent upon the diagnosed condition, such as Asthma, Allergic Conjunctivitis (AC) and Hay Fever. The quantity of dosage is contingent upon the method of delivery (e.g. Liquid or Solution / drops) delineated in the table underneath.Condition
Dosage
Administration
Asthma
, 20.0 mg/mL, 2.0 mg/dose, 2.0 mg/pump actuation, 2.0 %, 2.0 mg
Liquid, Solution / drops, Aerosol, metered - Oral, Liquid - Ophthalmic, Respiratory (inhalation), Solution / drops - Ophthalmic, , Aerosol, metered, Ophthalmic, Aerosol, metered - Respiratory (inhalation), Oral
Allergic Conjunctivitis (AC)
, 20.0 mg/mL, 2.0 mg/dose, 2.0 mg/pump actuation, 2.0 %, 2.0 mg
Liquid, Solution / drops, Aerosol, metered - Oral, Liquid - Ophthalmic, Respiratory (inhalation), Solution / drops - Ophthalmic, , Aerosol, metered, Ophthalmic, Aerosol, metered - Respiratory (inhalation), Oral
Hay Fever
, 20.0 mg/mL, 2.0 mg/dose, 2.0 mg/pump actuation, 2.0 %, 2.0 mg
Liquid, Solution / drops, Aerosol, metered - Oral, Liquid - Ophthalmic, Respiratory (inhalation), Solution / drops - Ophthalmic, , Aerosol, metered, Ophthalmic, Aerosol, metered - Respiratory (inhalation), Oral
Eye
, 20.0 mg/mL, 2.0 mg/dose, 2.0 mg/pump actuation, 2.0 %, 2.0 mg
Liquid, Solution / drops, Aerosol, metered - Oral, Liquid - Ophthalmic, Respiratory (inhalation), Solution / drops - Ophthalmic, , Aerosol, metered, Ophthalmic, Aerosol, metered - Respiratory (inhalation), Oral
Warnings
There are 20 known major drug interactions with Tilade.Common Tilade Drug Interactions
Drug Name
Risk Level
Description
Abacavir
Minor
Nedocromil may decrease the excretion rate of Abacavir which could result in a higher serum level.
Aclidinium
Minor
Nedocromil may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Nedocromil may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Nedocromil may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Allylestrenol
Minor
Nedocromil may decrease the excretion rate of Allylestrenol which could result in a higher serum level.
Tilade Toxicity & Overdose RiskSide effects of taking this drug may include headaches, blocked nose, burning, irritation or stinging eyes, bad taste, coughing, difficulty breathing, wheezing, pink eye, blurry vision, change in color vision, difficulty seeing in the dark, and increased sensitivity to sunlight.
Tilade Novel Uses: Which Conditions Have a Clinical Trial Featuring Tilade?
154 active clinical trials are investigating the potential of Tilade in alleviating Asthma, Eye Symptoms and Hay Fever conditions.Condition
Clinical Trials
Trial Phases
Asthma
157 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Eye
0 Actively Recruiting
Hay Fever
5 Actively Recruiting
Phase 2, Phase 1, Not Applicable, Phase 4
Allergic Conjunctivitis (AC)
3 Actively Recruiting
Phase 1, Phase 3
Tilade Reviews: What are patients saying about Tilade?
5Patient Review
8/28/2008 Tilade was a game-changer for me. It made being around people and perfumes, car exhaust, and humidity possible again. I'm on edge now that it's being discontinued.
2Patient Review
6/19/2017 Even when I follow the instructions for cleaning my inhaler very carefully, I often end up with no access to the drug because the inhaler is blocked. This is very frustrating!
Patient Q&A Section about tilade
Is tilade still available?
"The Tilade and Intal Forte inhalers have been discontinued. The supply of Nedocromil and sodium cromoglicate inhalers ran out in late November 2020." - Anonymous Online Contributor
Unverified Answer
What is tilade inhaler used for?
"Tilade CFC-Free Inhaler contains the medication nedocromil sodium and is used to treat asthma by preventing asthma attacks." - Anonymous Online Contributor
Unverified Answer
Is tilade a steroid?
"The drug Tilade CFC-Free contains nedocromil sodium, a non-steroidal agent with anti-inflammatory properties. When administered topically, it can help to reduce inflammation in the lungs." - Anonymous Online Contributor
Unverified Answer
Why was tilade discontinued?
"King Pharmaceuticals has decided to discontinue the manufacturing of Tilade Inhaler (nedocromil sodium inhalation consumol) because they have been unable to find a manufacturer for a chlorofluorocarbon propellant inhaler that meets their standards." - Anonymous Online Contributor
Unverified Answer