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What is Brovana
ArformoterolThe Generic name of this drug
Treatment SummaryArformoterol is a medication used to open up airways and make breathing easier for people with chronic obstructive pulmonary disease. It can be inhaled directly into the lungs. However, due to potential risks of severe asthma attacks, hospitalization, and death, its use is currently being reviewed.
Brovanais the brand name
Brovana Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Brovana
Arformoterol
2007
10
Approved as Treatment by the FDA
Arformoterol, otherwise called Brovana, is approved by the FDA for 1 uses such as Chronic Obstructive Pulmonary Disease .Chronic Obstructive Pulmonary Disease
Helps manage Chronic Obstructive Pulmonary Disease (COPD)
Effectiveness
How Brovana Affects PatientsArformoterol is a powerful medication that activates the body's beta2-adrenergic receptors, which are responsible for controlling air flow in the lungs. It is more effective than a similar drug, racemic formoterol, since it contains only the (R,R)-enantiomer, which is 1,000 times more powerful than the (S,S)-enantiomer. Arformoterol does not affect the beta1-adrenergic receptors.
How Brovana works in the bodyArformoterol is a drug that works by stimulating beta-2 receptors located in the heart and bronchial muscles. This stimulation causes the enzyme adenyl cyclase to increase, which in turn increases the levels of a chemical called cyclic AMP. This process relaxes the bronchial muscle and stops proinflammatory cells from releasing substances that can cause allergic reactions. In laboratory tests, arformoterol also has been shown to inhibit the release of substances such as histamines and leukotrienes from the lungs and to prevent allergic reactions in animals.
When to interrupt dosage
The suggested dose of Brovana is contingent upon the diagnosed condition. The amount of dosage varies in accordance with the prescribed technique of delivery featured in the table below.Condition
Dosage
Administration
Asthma
0.015 mg/mL,
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Chronic Obstructive Pulmonary Disease
0.015 mg/mL,
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Warnings
Brovana ContraindicationsCondition
Risk Level
Notes
Asthma
Do Not Combine
Pulse Frequency
Do Not Combine
Common Brovana Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Arformoterol.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Arformoterol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Arformoterol.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Arformoterol.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Arformoterol.
Brovana Toxicity & Overdose RiskA single oral dose of 5 mg/kg in dogs has been linked to death, which is about 4500 times the recommended daily dose for adults. Taking too much arformoterol can result in cardiac arrest and even death, so it is important to take the medication as directed and not combine it with other long-acting beta<sub>2</sub>-agonists.
Brovana Novel Uses: Which Conditions Have a Clinical Trial Featuring Brovana?
244 active clinical trials are being conducted to investigate the efficacy of Brovana in managing Asthma.Condition
Clinical Trials
Trial Phases
Chronic Obstructive Pulmonary Disease
100 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1, Phase 4
Asthma
158 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Early Phase 1, Phase 3
Brovana Reviews: What are patients saying about Brovana?
5Patient Review
3/15/2010 I don't have any personal experience, but from what I've heard from the doctors I work with, this treatment is extremely effective and their patients love it.
5Patient Review
4/23/2011 I take this medication for my chronic obstructive pulmonary disease (COPD), and it has been working great in conjunction with prednisone.
5Patient Review
6/29/2018 I've been using this treatment for nine years with no side effects. It's helped my asthma, COPD, and chronic bronchitis. I feel much healthier now and rarely get sick.
5Patient Review
9/12/2009 This helped me breathe better and cleared my bronchitis faster than albuterol. It also didn't make me shake after using it like albuterol did.
5Patient Review
5/10/20085Patient Review
7/10/2010 This drug is effective at quickly clearing lung congestion and loosening phlegm.
4Patient Review
10/13/20083.7Patient Review
7/9/2016 I've only been using this drug for a few days, and I've already experienced some uncomfortable side effects. Loose bowels could be from the Brovana or something else entirely, but either way it's not pleasant. Additionally, I've been having cramps in my hands and knees which may be due to the Lasix. All in all, it's been a bit of a tough adjustment period.
3Patient Review
3/15/2010 After using Brovana, I felt much better and my quality of life improved. I still had to use Pulmicort in conjunction with it, but it was worth it.
3Patient Review
11/21/2011 This didn't help me at all.
2.7Patient Review
7/25/2013 I started taking Brovana yesterday and it has done nothing to reduce my tremors. It's also very expensive, and my HMO won't cover it at a reduced rate. I can only afford to pay $86 per month for it, and that's on a limited income. These tremors are serious and I need something more than just a water pill like Lasixs.
2.7Patient Review
1/26/2012 My doctor prescribed this to me and since I have been using it, I use my albuteral only occasionally. I am breathing better than I have in a long time.
2.7Patient Review
9/21/20082.7Patient Review
5/15/2013 I'm currently taking this in conjunction with zopenex, so I can't speak to the full effect of this treatment yet.
2.3Patient Review
11/25/2010 This treatment is okay. It helped me a little bit, but I'm not sure it was worth the cost.
Patient Q&A Section about brovana
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What kind of drug is Brovana?
"Brovana is a bronchodilator that is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, which includes chronic bronchitis and emphysema."
Answered by AI
Is Brovana a long acting bronchodilator?
"The use of long-acting beta2-adrenergic agonists as monotherapy for asthma has been linked to an increased risk of asthma-related events."
Answered by AI
Can you mix Brovana and albuterol?
"If you use albuterol and Brovana together, you may be more likely to have heart-related side effects, such as an increased heart rate or blood pressure, or an irregular heart rhythm."
Answered by AI
Is Brovana a nebulizer?
"The nebulizer transforms the Brovana vial solution into a fine mist that the patient inhales. It is important that the patient reads the Patient Information Leaflet provided by the pharmacist before beginning use of the medication, and each time they get a refill."
Answered by AI