Brovana

Asthma, Chronic Obstructive Pulmonary Disease
Treatment
1 FDA approval
20 Active Studies for Brovana

What is Brovana

ArformoterolThe Generic name of this drug
Treatment SummaryArformoterol is a medication used to open up airways and make breathing easier for people with chronic obstructive pulmonary disease. It can be inhaled directly into the lungs. However, due to potential risks of severe asthma attacks, hospitalization, and death, its use is currently being reviewed.
Brovanais the brand name
image of different drug pills on a surface
Brovana Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Brovana
Arformoterol
2007
10

Approved as Treatment by the FDA

Arformoterol, otherwise called Brovana, is approved by the FDA for 1 uses such as Chronic Obstructive Pulmonary Disease .
Chronic Obstructive Pulmonary Disease
Helps manage Chronic Obstructive Pulmonary Disease (COPD)

Effectiveness

How Brovana Affects PatientsArformoterol is a powerful medication that activates the body's beta2-adrenergic receptors, which are responsible for controlling air flow in the lungs. It is more effective than a similar drug, racemic formoterol, since it contains only the (R,R)-enantiomer, which is 1,000 times more powerful than the (S,S)-enantiomer. Arformoterol does not affect the beta1-adrenergic receptors.
How Brovana works in the bodyArformoterol is a drug that works by stimulating beta-2 receptors located in the heart and bronchial muscles. This stimulation causes the enzyme adenyl cyclase to increase, which in turn increases the levels of a chemical called cyclic AMP. This process relaxes the bronchial muscle and stops proinflammatory cells from releasing substances that can cause allergic reactions. In laboratory tests, arformoterol also has been shown to inhibit the release of substances such as histamines and leukotrienes from the lungs and to prevent allergic reactions in animals.

When to interrupt dosage

The suggested dose of Brovana is contingent upon the diagnosed condition. The amount of dosage varies in accordance with the prescribed technique of delivery featured in the table below.
Condition
Dosage
Administration
Chronic Obstructive Pulmonary Disease
0.015 mg/mL,
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)
Asthma
0.015 mg/mL,
, Respiratory (inhalation), Solution, Solution - Respiratory (inhalation)

Warnings

Brovana Contraindications
Condition
Risk Level
Notes
Asthma
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Brovana.
Common Brovana Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Arformoterol.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Arformoterol.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Arformoterol.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Arformoterol.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Arformoterol.
Brovana Toxicity & Overdose RiskA single oral dose of 5 mg/kg in dogs has been linked to death, which is about 4500 times the recommended daily dose for adults. Taking too much arformoterol can result in cardiac arrest and even death, so it is important to take the medication as directed and not combine it with other long-acting beta<sub>2</sub>-agonists.
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Brovana Novel Uses: Which Conditions Have a Clinical Trial Featuring Brovana?

244 active clinical trials are being conducted to investigate the efficacy of Brovana in managing Asthma.
Condition
Clinical Trials
Trial Phases
Chronic Obstructive Pulmonary Disease
77 Actively Recruiting
Phase 3, Phase 1, Phase 2, Not Applicable, Early Phase 1, Phase 4
Asthma
92 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3

Brovana Reviews: What are patients saying about Brovana?

5Patient Review
3/15/2010
Brovana for Chronic Bronchitis
I don't have any personal experience, but from what I've heard from the doctors I work with, this treatment is extremely effective and their patients love it.
5Patient Review
4/23/2011
Brovana for COPD with Chronic Bronchitis
I take this medication for my chronic obstructive pulmonary disease (COPD), and it has been working great in conjunction with prednisone.
5Patient Review
6/29/2018
Brovana for COPD with Chronic Bronchitis
I've been using this treatment for nine years with no side effects. It's helped my asthma, COPD, and chronic bronchitis. I feel much healthier now and rarely get sick.
5Patient Review
9/12/2009
Brovana for Bronchi Muscle Spasm resulting from COPD
This helped me breathe better and cleared my bronchitis faster than albuterol. It also didn't make me shake after using it like albuterol did.
5Patient Review
5/10/2008
Brovana for Bronchi Muscle Spasm resulting from COPD
5Patient Review
7/10/2010
Brovana for Bronchospasm Prevention with COPD
This drug is effective at quickly clearing lung congestion and loosening phlegm.
4Patient Review
10/13/2008
Brovana for Chronic Bronchitis
3.7Patient Review
7/9/2016
Brovana for Prevention of Bronchospasms with Emphysema
I've only been using this drug for a few days, and I've already experienced some uncomfortable side effects. Loose bowels could be from the Brovana or something else entirely, but either way it's not pleasant. Additionally, I've been having cramps in my hands and knees which may be due to the Lasix. All in all, it's been a bit of a tough adjustment period.
3Patient Review
3/15/2010
Brovana for Osteoporosis
After using Brovana, I felt much better and my quality of life improved. I still had to use Pulmicort in conjunction with it, but it was worth it.
3Patient Review
11/21/2011
Brovana for COPD with Chronic Bronchitis
This didn't help me at all.
2.7Patient Review
7/25/2013
Brovana for Chronic Bronchitis
I started taking Brovana yesterday and it has done nothing to reduce my tremors. It's also very expensive, and my HMO won't cover it at a reduced rate. I can only afford to pay $86 per month for it, and that's on a limited income. These tremors are serious and I need something more than just a water pill like Lasixs.
2.7Patient Review
1/26/2012
Brovana for Emphysema
My doctor prescribed this to me and since I have been using it, I use my albuteral only occasionally. I am breathing better than I have in a long time.
2.7Patient Review
9/21/2008
Brovana for Prevention of Bronchospasms with Emphysema
2.7Patient Review
5/15/2013
Brovana for Prevention of Bronchospasms with Emphysema
I'm currently taking this in conjunction with zopenex, so I can't speak to the full effect of this treatment yet.
2.3Patient Review
11/25/2010
Brovana for Emphysema
This treatment is okay. It helped me a little bit, but I'm not sure it was worth the cost.
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Patient Q&A Section about brovana

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What kind of drug is Brovana?

"Brovana is a bronchodilator that is used to prevent bronchoconstriction in people with chronic obstructive pulmonary disease, which includes chronic bronchitis and emphysema."

Answered by AI

Is Brovana a long acting bronchodilator?

"The use of long-acting beta2-adrenergic agonists as monotherapy for asthma has been linked to an increased risk of asthma-related events."

Answered by AI

Can you mix Brovana and albuterol?

"If you use albuterol and Brovana together, you may be more likely to have heart-related side effects, such as an increased heart rate or blood pressure, or an irregular heart rhythm."

Answered by AI

Is Brovana a nebulizer?

"The nebulizer transforms the Brovana vial solution into a fine mist that the patient inhales. It is important that the patient reads the Patient Information Leaflet provided by the pharmacist before beginning use of the medication, and each time they get a refill."

Answered by AI

Clinical Trials for Brovana

Image of Stanford University in Stanford, United States.

MoblO2 for Chronic Lung Diseases

18+
All Sexes
Stanford, CA
Many patients with chronic lung disease (e.g., chronic obstructive pulmonary disease (COPD) or interstitial lung disease (ILD)) require supplemental oxygen (O2) at some point during their disease course. Practitioners prescribe O2 to patients with chronic lung disease in hopes of the following: 1) that it will limit desaturation events and combat breathlessness, thus preventing the frustratingly slow pace and numerous rest breaks patients are forced to adopt while doing even simple tasks; 2) that it will allow patients to be more active physically (perhaps increase their ability to exercise) and socially (perhaps leave the home more often); 3) that it will stave off putative complications of hypoxemia (e.g., cognitive dysfunction, pulmonary hypertension) and 4) that it will improve health-related quality of life (HRQL). However, despite the rationale for O2, and prescribers' good intentions, patients generally view O2 with frustration and fear - it threatens their HRQL, which is already impaired by having a condition that imposes itself on every aspect of their lives. Nasal cannulas and delivery devices call unwanted attention to patients when they are out in public. O2 users feel stigmatized and are often viewed as "smokers who get what they deserve, even if they never smoked a day in their lives" - or as disabled, sick or even infectious. O2 steals patients' independence, forcing them to plan their lives around it. The anxiety that patients and their caregivers experience around running out of oxygen, or not getting enough, immobilizes them and restricts participation in activities outside of the home. O2 disrupts the home environment, adding stress, and creating a burden for patients' caregiver-loved-ones who are often saddled with the responsibility of ensuring adequate equipment and supply of O2, and O2 is a constant reminder to patients they are living with a condition that could shorten their lives. O2 delivery equipment is typically heavy, unwieldy and intimidating. Different recommendations (e.g., insurance companies use 88% as a cut-off for SpO2, while many practitioners focus on 90%) make it confusing for patients, which almost certainly affects adherence. O2-requiringpatients are starving for things that can make their lives easier. An auto-adjusting O2 delivery device - one that automatically delivers the correct amount of O2 to maintain blood oxygen at desired, pre-set levels - would alleviate the need for patients to constantly (incessantly for many) monitor their peripheral oxygen saturation (SpO2) and adjust O2flow to meet the demands as exertion levels vary . The MoblO2 device is a battery-operated, light-weight, closed-loop O2 delivery device that houses a regulator (which attaches to compressed gas O2 tanks) and adjusts O2 flow to meet a pre-set blood oxygen level. A pulse oximeter is worn on the ear and transmits via Bluetooth to the device, which adjusts an internal valve to control flow on a second-to-second basis. The user sets the dial to the highest flow of O2 needed to meet the demands of activities they might perform (up to 15 liters per minute), and the device adjusts flow, up to the pre-set level to maintain SpO2 at a preset level (e.g., \> 90%). To conserve O2 supply in the tank - and to avoid over-oxygenation (which could be problematic for a small percentage of patients with the most severe COPD) - the MoblO2 begins to limit O2 flow at a SpO2 of 93%. The device can be manually over-ridden by the user, and should the battery run out - or the device fail for some unforeseen reason - the default position is valve open, so the users receive whatever flow of oxygen has been set on the dial. Given the substantial burdens of O2 on patients and their families, the hassles patients describe with having to monitor their SpO2 and repeatedly adjust the flow of O2 to meet their needs, patients and experts around the world have called for improvements in O2 delivery equipment. The MoblO2 is just such a remarkable improvement and a giant step forward in helping to ease the burdens of O2 on patients who require it. The purpose of this study is to investigate the effects of the MoblO2 O2 delivery device on a range of outcomes, including physical activity, amount (liters) O2 use; maintenance of adequate SpO2 levels; patient reported outcomes including symptoms, HRQL and satisfaction with the MoblO2 O2 device.
Waitlist Available
Has No Placebo
Stanford UniversityJeff Swigris, DO, MSMinnesota Health Solutions
Have you considered Brovana clinical trials? We made a collection of clinical trials featuring Brovana, we think they might fit your search criteria.Go to Trials
Image of The University of Tennessee Graduate School of Medicine in Knoxville, United States.

Nebulizer vs Inhaler for COPD

18+
All Sexes
Knoxville, TN
The purpose of this study is to compare the effectiveness of inhaled bronchodilators delivered via nebulizers vs. dry powder inhalers (DPIs) in symptomatic participants with Chronic Obstructive Pulmonary Disease (COPD) who have airflow obstruction (FEV1/FVC ≤ 70%) and show significant air trapping (RV ≥ 120% of predicted). The investigators hypothesize that, in patients with symptomatic COPD, therapy with a long-acting anti muscarinic agent/long-acting beta agonist (LAMA/LABA) combination administered by nebulizer will improve hyperinflation (increase in inspiratory capacity and reduction in residual volume) and reduce symptoms related to COPD to a greater extent than LAMA/LABA therapy given by a DPI. The study aims to demonstrate the following: 1. Compare the values of inspiratory capacity (IC) and residual volume (RV) in patients receiving LAMA/LABA by DPI with those receiving LAMA/LABA by nebulizer 2. Compare patient reported outcomes (COPD Assessment Test (CAT score), Baseline/Transition Dyspnea Index (BDI/TDI) and the St. George Respiratory Questionnaire (SGRQ) in symptomatic patients with COPD receiving LAMA/LABA by DPI with those receiving LAMA/LABA by nebulizer
Phase 4
Recruiting
The University of Tennessee Graduate School of MedicineTheravance Biopharma
Have you considered Brovana clinical trials? We made a collection of clinical trials featuring Brovana, we think they might fit your search criteria.Go to Trials
Have you considered Brovana clinical trials? We made a collection of clinical trials featuring Brovana, we think they might fit your search criteria.Go to Trials
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