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MRI Imaging for Asthma

N/A

Recruiting

Led By Grace E Parraga, PhD

Research Sponsored by Dr. Grace Parraga

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Subject able to perform reproducible pulmonary function testing (i.e., the 3 best acceptable spirograms have FEV1 values that do not vary more than 5% of the largest value or more than 100 ml, whichever is greater.)

Subjects male and female aged 18-60 with a clinical diagnosis of asthma

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 3 years

Awards & highlights

Study Summary

This trial will use 129Xenon and/or 3He image acquisition and analysis methods to study the relationship between lung structure and function in 120 asthma patients.

Who is the study for?

This trial is for stable, non-smoking adults aged 18-60 with asthma. Participants must understand the study and consent to it, have a history of less than 1 pack/year of smoking, and be able to perform consistent lung function tests with FEV1 over 60% predicted.Check my eligibility

What is being tested?

The trial is using Hyperpolarized Noble Gas MRI technology on 200 volunteers with asthma to explore how their lung structure relates to lung function. It involves imaging lungs using two types of gases: Xenon (129Xenon) and Helium (3He).See study design

What are the potential side effects?

While not explicitly listed in the provided information, potential side effects may include discomfort from holding breath during scans or mild dizziness from inhaling noble gases used for MRI imaging.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can perform consistent lung function tests.

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I am between 18 and 60 years old and have been diagnosed with asthma.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Ventilation Defect Percent as measured by Xenon-129 and/or Helium-3 MRI

Secondary outcome measures

Additional Pulmonary Function measurements

Dyspnea Scale

Forced Expiratory Volume (FEV1) measured by spirometry

+1 more

Trial Design

1Treatment groups

Experimental Treatment

Group I: Asthma PatientsExperimental Treatment1 Intervention

All enrolled asthma patients will undergo hyperpolarized noble gas MRI with Helium-3 and/or Xenon-129, Pulmonary Function Tests, Quality of Life Questionnaires, dyspnea scales in two visits over three years.

0 / 2Eligibility criteria met

Find a Location

Who is running the clinical trial?

Dr. Grace ParragaLead Sponsor

5 Previous Clinical Trials

285 Total Patients Enrolled

4 Trials studying Asthma

85 Patients Enrolled for Asthma

Grace E Parraga, PhDPrincipal InvestigatorRobarts Research Institute, The University of Western Ontario

14 Previous Clinical Trials

1,164 Total Patients Enrolled

4 Trials studying Asthma

85 Patients Enrolled for Asthma

Media Library

Asthma Patients Clinical Trial Eligibility Overview. Trial Name: NCT02351141 — N/A

Asthma Research Study Groups: Asthma Patients

Asthma Clinical Trial 2023: Asthma Patients Highlights & Side Effects. Trial Name: NCT02351141 — N/A

Asthma Patients 2023 Treatment Timeline for Medical Study. Trial Name: NCT02351141 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age range for participation in this experiment inclusive of geriatric individuals?

"This medical experiment is seeking out participants aged between 18 and 60."

Answered by AI

Are there still openings to partake in this clinical experiment?

"Affirmative. Clinicaltrials.gov has information indicating that this research project is presently enrolling participants, which commenced on the 1st of January 2015 and was recently updated on the 10th of May 2023. The trial requires 200 individuals to be recruited from two different sites."

Answered by AI

How many people are actively participating in the research initiative?

"Correct. According to the information on clinicaltrials.gov, recruitment for this medical trial is currently in progress. Initially posted on January 1st 2015 and recently updated on May 10th 2023, it aims to enlist 200 patients from 2 different sites."

Answered by AI

To whom does this clinical trial extend an invitation?

"Eligibility for this research study requires that participants suffer from asthma and are between 18 to 60 years old. At the moment, 200 people need to be recruited."

Answered by AI

Recent research and studies

RadiologyJournal

Pulmonary Ventilation Maps Generated with Free-breathing Proton MRI and a Deep Convolutional Neural Network

Capaldi, Dante P. I., Fumin Guo, Lei Xing, and Grace Parraga. 2021. “Pulmonary Ventilation Maps Generated with Free-breathing Proton MRI and a Deep Convolutional Neural Network”. Radiology. Radiological Society of North America (RSNA). doi:10.1148/radiol.2020202861.

clinicaltrials.govStudy

Structure and Function MRI of Asthma

Dr. Grace Parraga 2015. "Structure and Function MRI of Asthma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02351141.

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