N Acetylcysteine for Cognitive Impairment
Trial Summary
What is the purpose of this trial?
This trial tests if taking an NAC supplement can help improve brain function in patients with mild cognitive issues who are also in a heart rehab program. NAC works by protecting brain cells from damage. N-acetylcysteine (NAC) has been studied for its potential benefits in various conditions, including brain injury, cognitive impairment, and oxidative stress.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. However, if you use daily Nitroglycerin, you cannot participate in the trial.
What evidence supports the effectiveness of the drug N Acetylcysteine for cognitive impairment?
Research on N-acetylcysteine (NAC) for Alzheimer's disease showed that it helped improve some cognitive tasks, suggesting it might be beneficial for cognitive impairment. Additionally, studies on other cognition enhancers like piracetam have shown improvements in memory, which might indicate potential benefits of similar treatments.12345
Is N-acetylcysteine safe for human use?
How does the drug N-acetylcysteine differ from other treatments for cognitive impairment?
N-acetylcysteine is unique because it may help increase levels of glutathione, an important antioxidant, which could reduce oxidative stress linked to cognitive decline. Unlike other treatments, it is also available as a dietary supplement and has potential neuroprotective benefits, although its low bioavailability is a challenge.1011121314
Research Team
Krista L Lanctôt, PhD
Principal Investigator
Sunnybrook Research Institute
Eligibility Criteria
Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive oral NAC supplementation as an add-on therapy to improve cognitive function, with dosage increasing weekly until reaching 2,400 mg/day, alongside a cardiac rehabilitation program
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- N Acetylcysteine
- Placebo oral capsule
Find a Clinic Near You
Who Is Running the Clinical Trial?
Sunnybrook Health Sciences Centre
Lead Sponsor