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Anti-tumor antibiotic

Tamoxifen vs Etoposide for Recurrent Glioblastoma

Phase 2
Recruiting
Research Sponsored by AHS Cancer Control Alberta
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Women of child bearing potential (WOCBP) must have a negative serum (or urine) pregnancy test within 72 hours prior to the first dose of study treatment. WOCBP is defined as any female who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy or bilateral salpingectomy) and is not postmenopausal. Menopause is defined as 12 months of amenorrhea in a woman over age 45 years in the absence of other biological or physiological causes
Age from 18-65 years
Timeline
Screening 3 weeks
Treatment Varies
Follow Up throughout study completion, up to 5 years.
Awards & highlights

Study Summary

This trial will compare two treatments for people with a certain type of brain cancer.

Who is the study for?
This trial is for adults aged 18-65 with confirmed GBM that's worsened after initial treatment. They must have a measurable tumor on MRI, stable or reduced steroid use, and be in fair to good health (ECOG 0-2). Women who can bear children need a recent negative pregnancy test and agree to effective birth control during the study.Check my eligibility
What is being tested?
The study compares two drugs, etoposide and tamoxifen, for treating first recurrence of GBM. It's a phase II trial where patients are randomly assigned to receive one of these treatments at a single center.See study design
What are the potential side effects?
Possible side effects from etoposide include low blood counts, nausea, hair loss, and increased risk of infection. Tamoxifen may cause hot flashes, mood swings, blood clots, and vision changes.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am a woman who can have children and have a recent negative pregnancy test.
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I am between 18 and 65 years old.
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My GBM cancer has worsened after initial treatment with temozolomide.
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I can take care of myself and perform daily activities.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~throughout study completion, up to 5 years.
This trial's timeline: 3 weeks for screening, Varies for treatment, and throughout study completion, up to 5 years. for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
3 month progression-free survival
Secondary outcome measures
Adverse events
Health-related quality-of-life status
One-year progression-free survival
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: TamoxifenExperimental Treatment1 Intervention
Group II: EtoposideActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Tamoxifen
2005
Completed Phase 4
~30070

Find a Location

Who is running the clinical trial?

AHS Cancer Control AlbertaLead Sponsor
182 Previous Clinical Trials
36,152 Total Patients Enrolled
7 Trials studying Glioblastoma
349 Patients Enrolled for Glioblastoma

Media Library

Etoposide (Anti-tumor antibiotic) Clinical Trial Eligibility Overview. Trial Name: NCT04765098 — Phase 2
Glioblastoma Research Study Groups: Etoposide, Tamoxifen
Glioblastoma Clinical Trial 2023: Etoposide Highlights & Side Effects. Trial Name: NCT04765098 — Phase 2
Etoposide (Anti-tumor antibiotic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04765098 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the current enrollment figure for this clinical trial?

"Affirmative. As evidenced by clinicaltrials.gov, this medical trial is presently recruiting volunteers; it was first published on January 28th 2022 and has been recently updated on March 28th of the same year. The investigation requires 60 individuals from one single site."

Answered by AI

Do I meet the qualifications to partake in this experiment?

"People with glioblastoma aged between 18 and 65 are eligible to enroll in this clinical trial. A total of 60 participants need to be recruited."

Answered by AI

Is this experimental protocol accessible for senior citizens?

"This trial is accepting applicants that are of legal age and under the retirement threshold."

Answered by AI

What medical purpose does Tamoxifen generally serve?

"Tamoxifen has been found to be efficacious in treating small cell lung cancer (SCLC), cancers with estrogen receptors, and metastatic thymic malignancies."

Answered by AI

Has Tamoxifen been granted the official endorsement of the FDA?

"Because this trial is only at Phase 2, there are limited data points on efficacy and safety. As such, Tamoxifen was assigned a score of 2 by our team at Power."

Answered by AI

Are recruitment efforts still ongoing for this experiment?

"Affirmative. Statistics located on clinicaltrials.gov indicate that this experiment, which was first released on January 28th 2022, is currently recruiting individuals to participate in the study. To be exact, they are searching for 60 participants at one medical facility."

Answered by AI

What other research efforts have been undertaken involving Tamoxifen?

"Currently, the Tamoxifen clinical trials are well underway with 381 active studies and 114 of them in Phase 3. Although Houston, Texas is a major contributor to this research endeavour, there exists over 20 thousand sites conducting Tamoxifen related investigations."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Tamoxifen Versus Etoposide After First Recurrence in GBM Patients
2022. "Tamoxifen Versus Etoposide After First Recurrence in GBM Patients". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04765098.
~30 spots leftby Aug 2026
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