Pimecrolimus

Vitiligo, Psoriasis, Dermatitis, Atopic + 2 more
Treatment
3 FDA approvals
18 Active Studies for Pimecrolimus

What is Pimecrolimus

PimecrolimusThe Generic name of this drug
Treatment SummaryPimecrolimus is a topical cream used to treat atopic dermatitis (eczema). It is a medication that helps to reduce inflammation and modulate the body's immune system. It is marketed under the trade name Elidel and is distributed by Galderma in Canada.
Elidelis the brand name
image of different drug pills on a surface
Pimecrolimus Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Elidel
Pimecrolimus
2001
12

Approved as Treatment by the FDA

Pimecrolimus, otherwise known as Elidel, is approved by the FDA for 3 uses including Dermatitis, Atopic and Second Line Treatment .
Dermatitis, Atopic
Helps manage moderate Atopic dermatitis
Second Line Treatment
Helps manage Second Line Treatment
Dermatitis, Atopic
Helps manage mild Atopic dermatitis

Effectiveness

How Pimecrolimus Affects PatientsPimecrolimus is a medication used to treat atopic dermatitis (eczema). The exact cause of atopic dermatitis is unknown, but it is thought to be a result of the immune system's response to certain triggers. Pimecrolimus works by blocking the effects of chemicals released by the body that activate certain immune cells (T-cells and mast cells). This prevents these cells from causing inflammation, thus reducing the symptoms of atopic dermatitis.
How Pimecrolimus works in the bodyPimecrolimus works by binding to a protein called macrophilin-12 and blocking a calcium-dependent enzyme. This prevents T cells from becoming activated, which stops the body from releasing certain cytokines related to inflammation. Pimecrolimus stops the release of inflammatory cytokines and mediators from mast cells after they have been stimulated.

When to interrupt dosage

The proposed measure of Pimecrolimus is contingent upon the ascertained condition, including Second Line Treatment, Vitiligo and non-immunocompromised. The amount of dosage can be found in the table below, subject to the technique of delivery (e.g. Cream - Topical or Topical).
Condition
Dosage
Administration
Psoriasis
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Dermatitis, Atopic
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Dermatitis, Atopic
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Vitiligo
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical
Second Line Treatment
, 0.01 mg/mg, 1.0 %
, Topical, Cream, Cream - Topical

Warnings

There are 20 known major drug interactions with Pimecrolimus.
Common Pimecrolimus Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Pimecrolimus is combined with Acteoside.
Pimecrolimus Toxicity & Overdose RiskSide effects of Diclofenac cream may include a burning or stinging sensation, itching, redness, and skin infections at the site of application.
image of a doctor in a lab doing drug, clinical research

Pimecrolimus Novel Uses: Which Conditions Have a Clinical Trial Featuring Pimecrolimus?

16 active clinical trials are currently examining the potential of Pimecrolimus to provide relief from Dermatitis, Atopic Dermatitis and Second Line Treatment.
Condition
Clinical Trials
Trial Phases
Dermatitis, Atopic
0 Actively Recruiting
Psoriasis
0 Actively Recruiting
Dermatitis, Atopic
0 Actively Recruiting
Vitiligo
18 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Second Line Treatment
0 Actively Recruiting

Pimecrolimus Reviews: What are patients saying about Pimecrolimus?

4.3Patient Review
1/24/2008
Pimecrolimus for Atopic Dermatitis
When used as directed, this product provides good relief. I find that using it every few days prevents the condition from flaring up again.
4Patient Review
10/12/2008
Pimecrolimus for Eczema Skin Condition Resisting Treatment
This was the only treatment that gave me relief from my incessant itching.
2.3Patient Review
11/28/2020
Pimecrolimus for Atopic Dermatitis
Did not provide the relief I was hoping for.
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Patient Q&A Section about pimecrolimus

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is pimecrolimus an antifungal cream?

"Pimecrolimus had an antifungal effect against 109 Malassezia strains, with MIC values ranging from 16 to 64 μg/ml. This means that it inhibited the growth of approximately 90% of the strains at a concentrations of 16 or 32 μg/ml."

Answered by AI

Is pimecrolimus cream a steroid?

"Elidel is a cream that contains 1% of the topical immunomodulator pimecrolimus. It was specifically developed to treat atopic dermatitis in children as young as 2 years old."

Answered by AI

Is pimecrolimus safe for face?

"Pimecrolimus cream can be applied to the skin on the head, face, and neck. Apply the cream by gently rubbing it into the skin until it is completely absorbed. Wash your hands with soap and water to remove any leftover pimecrolimus cream."

Answered by AI

What is pimecrolimus ointment used for?

"Pimecrolimus is a topical calcineurin inhibitor used to treat mild to moderate atopic dermatitis in patients unresponsive to other treatments. Topical calcineurin inhibitors work by decreasing inflammation."

Answered by AI

Clinical Trials for Pimecrolimus

Have you considered Pimecrolimus clinical trials? We made a collection of clinical trials featuring Pimecrolimus, we think they might fit your search criteria.
Have you considered Pimecrolimus clinical trials? We made a collection of clinical trials featuring Pimecrolimus, we think they might fit your search criteria.
Have you considered Pimecrolimus clinical trials? We made a collection of clinical trials featuring Pimecrolimus, we think they might fit your search criteria.