Permethrin

Scabies, lice of the pubic area, Norwegian scabies + 1 more

Treatment

3 FDA approvals

1 Active Study for Permethrin

Treatment for

Scabies

What is Permethrin

PermethrinThe Generic name of this drug

Treatment SummaryPermethrin is an insecticide used to treat lice and scabies. It is a yellow to light orange-brown colored liquid or solid material.

Elimiteis the brand name

image of different drug pills on a surface

Permethrin Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Elimite

Permethrin

1989

Approved as Treatment by the FDA

Permethrin, otherwise called Elimite, is approved by the FDA for 3 uses like Scabies <infestation> and Scabies .

Scabies <infestation>

Scabies

Head

Effectiveness

How Permethrin Affects PatientsPermethrin is a type of insecticide that is effective against a wide range of bugs, such as lice, ticks, fleas, mites, and other tiny animals.

How Permethrin works in the bodyPermethrin disturbs the nerve cells of pests, preventing them from functioning correctly. It interferes with the flow of sodium ions in the cells, leading to paralysis.

When to interrupt dosage

The proposed dosage of Permethrin is reliant upon the determined affliction, such as Scabies, Head and lice of the pubic area. The sum of dosage depends on the procedure of delivery (e.g. Lotion or Rinse - Topical) represented in the table below.

Condition

Dosage

Administration

Scabies

0.01 mg/mL, , 0.05 mg/mg, 56.0 mg/mL, 5.0 %, 1.0 %, 0.0005 mg/mg, 10.0 mg/mL, 27.8 mg/mL

, Lotion, Topical, Lotion - Topical, Cream, Cream - Topical, Shampoo, Shampoo - Topical, Kit, Liquid, Liquid - Topical, Cutaneous, Cream - Cutaneous, Rinse - Topical, Rinse, Kit - Topical

lice of the pubic area

0.01 mg/mL, , 0.05 mg/mg, 56.0 mg/mL, 5.0 %, 1.0 %, 0.0005 mg/mg, 10.0 mg/mL, 27.8 mg/mL

, Lotion, Topical, Lotion - Topical, Cream, Cream - Topical, Shampoo, Shampoo - Topical, Kit, Liquid, Liquid - Topical, Cutaneous, Cream - Cutaneous, Rinse - Topical, Rinse, Kit - Topical

Norwegian scabies

0.01 mg/mL, , 0.05 mg/mg, 56.0 mg/mL, 5.0 %, 1.0 %, 0.0005 mg/mg, 10.0 mg/mL, 27.8 mg/mL

, Lotion, Topical, Lotion - Topical, Cream, Cream - Topical, Shampoo, Shampoo - Topical, Kit, Liquid, Liquid - Topical, Cutaneous, Cream - Cutaneous, Rinse - Topical, Rinse, Kit - Topical

Head

0.01 mg/mL, , 0.05 mg/mg, 56.0 mg/mL, 5.0 %, 1.0 %, 0.0005 mg/mg, 10.0 mg/mL, 27.8 mg/mL

, Lotion, Topical, Lotion - Topical, Cream, Cream - Topical, Shampoo, Shampoo - Topical, Kit, Liquid, Liquid - Topical, Cutaneous, Cream - Cutaneous, Rinse - Topical, Rinse, Kit - Topical

Warnings

There are 20 known major drug interactions with Permethrin.

Common Permethrin Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Minor

Permethrin may decrease the excretion rate of Aclidinium which could result in a higher serum level.

Acrivastine

Minor

Permethrin may decrease the excretion rate of Acrivastine which could result in a higher serum level.

Albutrepenonacog alfa

Minor

Permethrin may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.

Almasilate

Minor

Permethrin may decrease the excretion rate of Almasilate which could result in a higher serum level.

Alogliptin

Minor

Permethrin may decrease the excretion rate of Alogliptin which could result in a higher serum level.

Permethrin Toxicity & Overdose RiskThe lowest toxic dose of the drug for rats orally is between 430-4000mg/kg, and 2000mg/kg for rabbits when applied to the skin.

image of a doctor in a lab doing drug, clinical research

Permethrin Novel Uses: Which Conditions Have a Clinical Trial Featuring Permethrin?

A single clinical trial is presently underway to ascertain the potency of Permethrin in providing relief from Pubic Lice, Scabies and Norwegian Scabies.

Condition

Clinical Trials

Trial Phases

Head

0 Actively Recruiting

lice of the pubic area

0 Actively Recruiting

Norwegian scabies

0 Actively Recruiting

Scabies

1 Actively Recruiting

Phase 4

Patient Q&A Section about permethrin

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is permethrin harmful to humans?

"Long-term side effects are largely unknown.

Permethrin is a pyrethroid that can have harmful effects if inhaled, ingested, or absorbed through skin. Formulations of permethrin can be non-toxic to moderately toxic, and short-term side effects can include irritation of the eyes, skin, nose, and throat, as well as potentially difficulty breathing. The long-term effects of permethrin are largely unknown."

Answered by AI

What is permethrin used for?

"Permethrin 1% lotion is used to treat head lice infections. It destroys both the lice and their eggs. The 5% cream is used to treat scabies infections by destroying the mites which cause scabies."

Answered by AI

How much permethrin is toxic to humans?

"The available data on neuro toxicity indicates that exposure to permethrin at a level of 6.8 × 10 −5 mg/kg per day is approximately 3 million times safe for daily human exposure."

Answered by AI