Your session is about to expire
What is Fluorouracil
FluorouracilThe Generic name of this drug
Treatment SummaryCapecitabine is a type of medication used to treat cancer. It works by interfering with the process of DNA synthesis and preventing the growth of cancer cells.
Efudexis the brand name
Fluorouracil Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Efudex
Fluorouracil
1970
62
Approved as Treatment by the FDA
Fluorouracil, also known as Efudex, is approved by the FDA for 1 uses like Actinic keratosis .Actinic keratosis
Used to treat hyperkeratotic actinic keratosis in combination with Salicylic acid
Effectiveness
How Fluorouracil Affects PatientsFluorouracil is a drug that helps stop cancer cells from growing. It does this by preventing the building blocks of DNA (purine and pyrimidine) from being incorporated into the DNA during the "S" phase of the cell cycle. Fluorouracil also blocks an enzyme that changes a type of nucleotide into the deoxy derivative, and it stops the incorporation of the thymidine nucleotide into the DNA strand, which stops DNA synthesis.
How Fluorouracil works in the bodyFluorouracil works by binding to an enzyme called thymidylate synthase. This prevents the formation of a compound used in DNA and RNA synthesis, which leads to cell death. It can also interfere with protein production by taking the place of a compound normally used in RNA processing.
When to interrupt dosage
The proposed dose of Fluorouracil is contingent upon the diagnosed malady, such as Actinic Keratosis, Verruca (Warts) and non-immunocompromised. The amount of dosage can be found in the table beneath, contingent upon the method of delivery (e.g. Solution - Topical or Injection, solution).Condition
Dosage
Administration
Rectal Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Verruca (Warts)
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Colon Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Superficial Basal Cell Carcinoma
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Breast Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Pancreatic Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Actinic Keratosis
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Stomach Cancer
, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL
, Intravenous, Injection, solution - Intravenous, Injection, solution, Topical, Cream, Cream - Topical, Solution, Solution - Topical, Solution - Intravenous, Liquid, Liquid - Intravenous, Kit, Injection, Injection - Intravenous
Warnings
Fluorouracil ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Fluorouracil Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Abetimus.
Acenocoumarol
Major
The metabolism of Acenocoumarol can be decreased when combined with Fluorouracil.
Acteoside
Major
The risk or severity of adverse effects can be increased when Fluorouracil is combined with Acteoside.
Fluorouracil Toxicity & Overdose RiskThe lowest toxic dose in mice when taken orally is 230mg/kg.
Fluorouracil Novel Uses: Which Conditions Have a Clinical Trial Featuring Fluorouracil?
1138 active trials are currently assessing Fluorouracil's potential as a therapeutic agent in Stomach Cancer, Colon Cancer and Rectal Cancer.Condition
Clinical Trials
Trial Phases
Breast Cancer
716 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable, Early Phase 1, Phase 4
Colon Cancer
64 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Pancreatic Cancer
229 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Actinic keratosis
0 Actively Recruiting
Verruca (Warts)
0 Actively Recruiting
Actinic Keratosis
11 Actively Recruiting
Not Applicable, Phase 2, Phase 3, Phase 1
Stomach Cancer
125 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable
Rectal Cancer
52 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1
Superficial Basal Cell Carcinoma
4 Actively Recruiting
Phase 3, Phase 2, Not Applicable
Fluorouracil Reviews: What are patients saying about Fluorouracil?
5Patient Review
2/25/2022 I'm only on day 12 of the treatment, and I've already started to see results. There are still some red patches on my forehead and temples, but they're starting to itch now so I know the worst is yet to come. However, this is a small price to pay for the stupidity of not protecting myself from the sun while playing golf in my 30s.
5Patient Review
4/16/2022 I've used this medication a few times now and have had great results. I simply apply it to a small area of my face, wait for the skin to start breaking down, then cover with a bandaid. After the skin heals, I can move on to another spot. It's time-consuming, but it works wonders!
5Patient Review
3/6/2022 While this treatment is incredibly difficult, it's still the best option out there. I've been using it for over 30 years to combat basal and squamous cell carcinoma.
5Patient Review
7/20/2022 I'm really confused by the negative reviews for this product. I followed the instructions to a T and found that it worked great for me. The spot turned red, scabbed over, and then disappeared. It was easy to use, painless, and avoided surgery.
5Patient Review
2/12/2022 Despite an initial breakout and some discomfort, this treatment really helped my skin regenerate. I would recommend using Aquaphor to help soothe the skin afterwards.
4.7Patient Review
9/19/2022 I've been using this treatment on and off for a decade, and it really works wonders. I usually only do the full scalp treatment when absolutely necessary, as it can be painful. The process isn't pretty, but wearing a hat while you're out and about will help hide it from others until it's done. Once the treatment is finished, I make sure to keep an eye out for any dry or scabby patches so that I can spot treat them immediately.
4Patient Review
10/7/2022 Just finished my six week treatment after only a small amount of cancer remained after removal. I was expecting the redness, itching, and tenderness, as well as the scales. The small discomfort wasn't bad at all. Been in the sun all my life. Now go out with long sleeve shirts that have UV protection. Bald head always has a hat, and will wear bucket for extra for head and ears. Sunscreen on ears, nose and anything exposed.
3Patient Review
8/2/2022 I unfortunately had pre-cancerous spots on my lips, so I began using the F. Cream. It's been a nightmare because it has made my lips incredibly sore and sensitive. Almost impossible to eat or drink without pain, and smiling is out of the question. One more week to go and hopefully this will be resolved.
1Patient Review
2/4/2022 I would never recommend this facial treatment to anyone. I went through the application process and recovery only to see a very small improvement. If you have a sedentary lifestyle, it may be OK (other than continuous sleepless nights). If you are an active, outdoors person, standby for "hell."
Patient Q&A Section about fluorouracil
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does fluorouracil do to your skin?
"This medication is used to treat pre-cancerous and cancerous skin growths by causing the death of abnormal cells."
Answered by AI
How long does it take for fluorouracil to start working?
"It usually takes at least 3 weeks for the medication to work, but it may take as long as 12 weeks. The skin around the area where the medication is applied will look red, swollen, and scaly during the first few weeks of treatment, which is a sign that the medication is working."
Answered by AI
What is fluorouracil used to treat?
"Fluorouracil topical is a medication used to treat actinic or solar keratoses and a type of skin cancer called superficial basal cell carcinoma. This medicine is available only with a doctor's prescription. This product is available in cream form."
Answered by AI
Is fluorouracil a chemotherapy drug?
"Fluorouracil belongs to a class of chemotherapy drugs called anti metabolites. Anti metabolites are similar to normal body molecules, but they have a slightly different structure. These differences mean that anti metabolites can inhibit the function of cancer cells."
Answered by AI