Fluorouracil

Breast Cancer, Carcinoma, Basal Cell, Rectal Cancer + 6 more

Treatment

1 FDA approval

20 Active Studies for Fluorouracil

What is Fluorouracil

Fluorouracil

The Generic name of this drug

Treatment Summary

Capecitabine is a type of medication used to treat cancer. It works by interfering with the process of DNA synthesis and preventing the growth of cancer cells.

Efudex

is the brand name

image of different drug pills on a surface

Fluorouracil Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Efudex

Fluorouracil

1970

62

Approved as Treatment by the FDA

Fluorouracil, also known as Efudex, is approved by the FDA for 1 uses like Actinic keratosis .

Actinic keratosis

Used to treat hyperkeratotic actinic keratosis in combination with Salicylic acid

Effectiveness

How Fluorouracil Affects Patients

Fluorouracil is a drug that helps stop cancer cells from growing. It does this by preventing the building blocks of DNA (purine and pyrimidine) from being incorporated into the DNA during the "S" phase of the cell cycle. Fluorouracil also blocks an enzyme that changes a type of nucleotide into the deoxy derivative, and it stops the incorporation of the thymidine nucleotide into the DNA strand, which stops DNA synthesis.

How Fluorouracil works in the body

Fluorouracil works by binding to an enzyme called thymidylate synthase. This prevents the formation of a compound used in DNA and RNA synthesis, which leads to cell death. It can also interfere with protein production by taking the place of a compound normally used in RNA processing.

When to interrupt dosage

The proposed dose of Fluorouracil is contingent upon the diagnosed malady, such as Actinic Keratosis, Verruca (Warts) and non-immunocompromised. The amount of dosage can be found in the table beneath, contingent upon the method of delivery (e.g. Solution - Topical or Injection, solution).

Condition

Dosage

Administration

Actinic Keratosis

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Breast Cancer

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Warts

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Actinic keratosis

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Carcinoma, Basal Cell

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Stomach Cancer

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Rectal Cancer

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Colon Cancer

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Pancreatic Cancer

, 50.0 mg/mL, 0.005 mg/mg, 0.05 mg/mg, 0.04 mg/mg, 20.0 mg/mL, 5.0 %, 1.0 %, 0.5 %, 250.0 mg/mL, 0.01 mg/mg, 0.2 mg/mg, 10.0 mg/mL, 5.0 mg/mg, 125.0 mg/mL, 4.0 %, 100.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Cream - Topical, Topical, Cream, Solution - Topical, Solution, Solution - Intravenous, Liquid - Intravenous, Liquid, Kit, Injection, Injection - Intravenous

Warnings

Fluorouracil Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Fluorouracil.

Common Fluorouracil Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Fluorouracil is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Fluorouracil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abetimus

Major

The risk or severity of adverse effects can be increased when Fluorouracil is combined with Abetimus.

Acenocoumarol

Major

The metabolism of Acenocoumarol can be decreased when combined with Fluorouracil.

Acteoside

Major

The risk or severity of adverse effects can be increased when Fluorouracil is combined with Acteoside.

Fluorouracil Toxicity & Overdose Risk

The lowest toxic dose in mice when taken orally is 230mg/kg.

image of a doctor in a lab doing drug, clinical research

Fluorouracil Novel Uses: Which Conditions Have a Clinical Trial Featuring Fluorouracil?

1138 active trials are currently assessing Fluorouracil's potential as a therapeutic agent in Stomach Cancer, Colon Cancer and Rectal Cancer.

Condition

Clinical Trials

Trial Phases

Pancreatic Cancer

169 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4

Stomach Cancer

171 Actively Recruiting

Phase 2, Phase 3, Phase 4, Phase 1, Not Applicable, Early Phase 1

Rectal Cancer

43 Actively Recruiting

Phase 3, Phase 2, Not Applicable, Phase 1

Colon Cancer

52 Actively Recruiting

Not Applicable, Phase 1, Phase 2

Breast Cancer

19 Actively Recruiting

Phase 2, Phase 1, Not Applicable

Actinic keratosis

0 Actively Recruiting

Carcinoma, Basal Cell

0 Actively Recruiting

Warts

0 Actively Recruiting

Actinic Keratosis

8 Actively Recruiting

Not Applicable, Phase 2, Phase 3, Phase 1, Phase 4

Fluorouracil Reviews: What are patients saying about Fluorouracil?

5

Patient Review

2/25/2022

Fluorouracil for Roughened Red Patches of Skin due to Sun Exposure

I'm only on day 12 of the treatment, and I've already started to see results. There are still some red patches on my forehead and temples, but they're starting to itch now so I know the worst is yet to come. However, this is a small price to pay for the stupidity of not protecting myself from the sun while playing golf in my 30s.

5

Patient Review

4/16/2022

Fluorouracil for Superficial Basal Cell Carcinoma of the Skin

I've used this medication a few times now and have had great results. I simply apply it to a small area of my face, wait for the skin to start breaking down, then cover with a bandaid. After the skin heals, I can move on to another spot. It's time-consuming, but it works wonders!

5

Patient Review

3/6/2022

Fluorouracil for Superficial Basal Cell Carcinoma of the Skin

While this treatment is incredibly difficult, it's still the best option out there. I've been using it for over 30 years to combat basal and squamous cell carcinoma.

5

Patient Review

7/20/2022

Fluorouracil for Superficial Basal Cell Carcinoma of the Skin

I'm really confused by the negative reviews for this product. I followed the instructions to a T and found that it worked great for me. The spot turned red, scabbed over, and then disappeared. It was easy to use, painless, and avoided surgery.

5

Patient Review

2/12/2022

Fluorouracil for Roughened Red Patches of Skin due to Sun Exposure

Despite an initial breakout and some discomfort, this treatment really helped my skin regenerate. I would recommend using Aquaphor to help soothe the skin afterwards.

4.7

Patient Review

9/19/2022

Fluorouracil for Superficial Basal Cell Carcinoma of the Skin

I've been using this treatment on and off for a decade, and it really works wonders. I usually only do the full scalp treatment when absolutely necessary, as it can be painful. The process isn't pretty, but wearing a hat while you're out and about will help hide it from others until it's done. Once the treatment is finished, I make sure to keep an eye out for any dry or scabby patches so that I can spot treat them immediately.

4

Patient Review

10/7/2022

Fluorouracil for Superficial Basal Cell Carcinoma of the Skin

Just finished my six week treatment after only a small amount of cancer remained after removal. I was expecting the redness, itching, and tenderness, as well as the scales. The small discomfort wasn't bad at all. Been in the sun all my life. Now go out with long sleeve shirts that have UV protection. Bald head always has a hat, and will wear bucket for extra for head and ears. Sunscreen on ears, nose and anything exposed.

3

Patient Review

8/2/2022

Fluorouracil for Roughened Red Patches of Skin due to Sun Exposure

I unfortunately had pre-cancerous spots on my lips, so I began using the F. Cream. It's been a nightmare because it has made my lips incredibly sore and sensitive. Almost impossible to eat or drink without pain, and smiling is out of the question. One more week to go and hopefully this will be resolved.

1

Patient Review

2/4/2022

Fluorouracil for Roughened Red Patches of Skin due to Sun Exposure

I would never recommend this facial treatment to anyone. I went through the application process and recovery only to see a very small improvement. If you have a sedentary lifestyle, it may be OK (other than continuous sleepless nights). If you are an active, outdoors person, standby for "hell."
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about fluorouracil

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does fluorouracil do to your skin?

"This medication is used to treat pre-cancerous and cancerous skin growths by causing the death of abnormal cells."

Answered by AI

How long does it take for fluorouracil to start working?

"It usually takes at least 3 weeks for the medication to work, but it may take as long as 12 weeks. The skin around the area where the medication is applied will look red, swollen, and scaly during the first few weeks of treatment, which is a sign that the medication is working."

Answered by AI

What is fluorouracil used to treat?

"Fluorouracil topical is a medication used to treat actinic or solar keratoses and a type of skin cancer called superficial basal cell carcinoma. This medicine is available only with a doctor's prescription. This product is available in cream form."

Answered by AI

Is fluorouracil a chemotherapy drug?

"Fluorouracil belongs to a class of chemotherapy drugs called anti metabolites. Anti metabolites are similar to normal body molecules, but they have a slightly different structure. These differences mean that anti metabolites can inhibit the function of cancer cells."

Answered by AI

Clinical Trials for Fluorouracil

Image of NEXT Dallas in Dallas, United States.

JMT108 for Cancer

18+
All Sexes
Dallas, TX

The goal of this clinical trial is to test JMT108, a type of drug called a bispecific antibody in adult patients with locally advanced or metastatic solid tumors. The main questions it aims to answer are: * To assess the safety and tolerability of JMT108 at increasing doses and determine the dose and schedule to be used in the second part of the study (Phase 1a) * To assess effectiveness of JMT108 in participants with locally advanced or metastatic tumors (Phase 1b) * To evaluate how quickly JMT108 is metabolized by the body (pharmacokinetics or PK) * To evaluate if antibodies to the study drug develop (immunogenicity) * To evaluate preliminary efficacy to the drug * To explore the pharmacodynamic (PD) characteristics of JMT108 * To explore the correlation between biomarker levels and preliminary efficacy Participants will: * Provide written informed consent * Undergo screening tests to ensure they are eligible for study treatment * Attend all required study visits and receive JMT108 by intravenous injection every 2 weeks until the study doctor determines study treatment should be stopped, based on how well a participant is doing on treatment * Be followed for progression every 3 months for up to 2 years

Phase 1
Recruiting

NEXT Dallas (+1 Sites)

Conjupro Biotherapeutics, Inc.

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Supplemental Imaging for Breast Cancer

25 - 55
Female
St Louis, MO

Recent research has shown that, among women with extremely dense breasts and normal results on mammogram, magnetic resonance imaging (MRI) use has significantly reduced the occurrence of breast cancer that is diagnosed during the time between two regular screening mammograms (also known as interval cancers). The investigators have developed and validated an approach to use the whole mammogram image, develop a mammogram risk score (MRS), and calibrate this to the SEER breast cancer incidence rates for US women. This model (Prognosia Breast) generates an absolute 5-year risk of breast cancer and classifies approximately 5.7% of the population as high risk using the ASCO 3% cut point as used for endocrine therapy to reduce risk. Follow-up generates an incidence of 25.2 cases per 1,000 women per year.

Waitlist Available
Has No Placebo

Washington University School of Medicine

Tabassum Ahmad, M.D.

Image of Memorial Sloan Kettering Basking Ridge (Consent Only) in Basking Ridge, United States.

Multiparametric Ultrasound for Cancer

18+
All Sexes
Basking Ridge, NJ

The researchers are doing this study to see how well a type of ultrasound imaging called multiparametric ultrasound (mpUS), can be used to examine, evaluate, and provide information about different cancerous and non-cancerous tissue. The researchers will compare the results of mpUS imaging to standard ultrasound imaging and other standard tests. mpUS imaging is a type of ultrasound imaging that combines different ultrasound methods and analysis to create a more detailed and accurate assessment of tissue. Standard ultrasound provides a basic image of tissue structure, but mpUS imaging can also show blood vessels, blood flow, and detailed tissue structure (microstructure). The researchers think that mpUS may be a better way for evaluating cancer because it combines different ultrasound methods to assess tissue.

Recruiting
Has No Placebo

Memorial Sloan Kettering Basking Ridge (Consent Only) (+6 Sites)

Mark T Burgess, MD

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GEH300079 PET/CT for Colorectal Cancer

18+
All Sexes
Grand Rapids, MI

This study is a Phase 2/3, prospective, multicenter, open-label, non-randomized clinical trial, in which GEH300079 (68Ga) PET/CT images will be acquired in patients with primary colorectal, gastric, ovarian, or Pancreatic Ductal Adenocarcinoma (PDAC) cancers and known or suspected Peritoneal Carcinomatosis (PC) before or after institutional Standard of Care (SoC) imaging. The primary objective is to evaluate the diagnostic performance of GEH300079 (68Ga) PET/CT for the detection of PC in patients with colorectal, gastric, or ovarian primary cancers, using a composite standard of truth (SoT), in a region-based analysis. The detection of PC in patients with primary PDAC will be explored in the Phase 2 part of the study. The study is comprised of 2 distinct parts: Phase 2 aims to confirm the statistical and scientific assumptions for the Phase 3 part, and to confirm the optimal dose and timing of acquisition of GEH300079 (68Ga) PET/CT in the PC indication. Phase 2 includes 2 cohorts: Cohort A (participants with colorectal, ovarian and gastric primary cancer), and Cohort B (participants with primary PDAC), where analysis of Cohort B is descriptive only. Phase 3 aims to demonstrate the safety and efficacy of GEH300079 (68Ga) PET/CT for the detection of PC in patients with confirmed colorectal, gastric or ovarian primary cancers.

Phase 2 & 3
Waitlist Available

BAMF Health

GE Healthcare

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