Cellcept

Immunosuppressive Agents, Kidney Transplant, Cardiac Transplant + 1 more
Treatment
20 Active Studies for Cellcept

What is Cellcept

Mycophenolate mofetilThe Generic name of this drug
Treatment SummaryMycophenolate mofetil, also known as MMF or CellCept, is a drug used to prevent the rejection of transplanted organs. It is often combined with other drugs, such as cyclosporine and corticosteroids, to make it more effective. It has also been studied for the treatment of autoimmune diseases, such as nephritis. Unlike other immunosuppressants, MMF does not usually cause nephrotoxicity or fibrosis. It was approved for use in 1995 and is manufactured by Roche Pharmaceuticals. Mycophenolate mofetil is a derivative of mycophen
CellCeptis the brand name
Cellcept Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
CellCept
Mycophenolate mofetil
1995
22

Effectiveness

How Cellcept Affects PatientsMycophenolate mofetil is a medication that converts into mycophenolic acid (MPA) in the body. MPA helps to reduce the risk of transplant rejection by blocking the production of antibodies that cause the body to reject the transplant. This leads to higher chances of successful transplants and helps to avoid the serious problems that can come from transplant rejection.
How Cellcept works in the bodyMycophenolate's active metabolite, mycophenolic acid, stops T cells and B cells from growing and producing harmful antibodies. It also prevents cells that are part of inflammation from sticking to the walls of blood vessels. Mycophenolate blocks the production of guanosine triphosphate, an important molecule used in making DNA, RNA, and proteins. It also reduces tetrahydrobiopterin, which lowers the amount of peroxynitrite, a molecule that causes inflammation. All of these effects work together to decrease inflammation.

When to interrupt dosage

The proposed measure of Cellcept is contingent upon the certified illness, including Rejection; Transplant, Liver, Rejection; Transplant, Kidney and Heart. The amount of dosage is reliant upon the mode of delivery (e.g. Powder, for suspension - Oral or Oral) featured in the table beneath.
Condition
Dosage
Administration
Kidney Transplant
, 500.0 mg, 250.0 mg, 50.0 mg/mL, 200.0 mg/mL, 1000.0 mg/mL
Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, , Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Immunosuppressive Agents
, 500.0 mg, 250.0 mg, 50.0 mg/mL, 200.0 mg/mL, 1000.0 mg/mL
Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, , Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Cardiac Transplant
, 500.0 mg, 250.0 mg, 50.0 mg/mL, 200.0 mg/mL, 1000.0 mg/mL
Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, , Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous
Organ Transplantation
, 500.0 mg, 250.0 mg, 50.0 mg/mL, 200.0 mg/mL, 1000.0 mg/mL
Tablet, Tablet - Oral, Tablet, coated, Tablet, coated - Oral, Intravenous, Powder, for solution, Powder, for solution - Intravenous, Injection, powder, for solution, Injection, powder, for solution - Intravenous, , Oral, Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Powder, for suspension, Powder, for suspension - Oral, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous

Warnings

Cellcept has three contraindications, thus it should not be taken in combination with the conditions provided in the table below.Cellcept Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Mycophenolate Mofetil may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Mycophenolate Mofetil may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Mycophenolate Mofetil may interact with Pulse Frequency
There are 20 known major drug interactions with Cellcept.
Common Cellcept Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abetimus
Major
The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Acteoside.
Aldosterone
Major
The risk or severity of adverse effects can be increased when Mycophenolate mofetil is combined with Aldosterone.
Cellcept Toxicity & Overdose RiskThe most toxic dose of mycophenolate mofetil for rats is 250mg/kg and more than 4000mg/kg for mice. Overdosing can cause a decrease in white or neutrophil blood cells, as well as stomach issues.
image of a doctor in a lab doing drug, clinical research

Cellcept Novel Uses: Which Conditions Have a Clinical Trial Featuring Cellcept?

16 active trials are being conducted to assess the potential of Cellcept in managing Heart, Liver and Kidney Transplant Rejection.
Condition
Clinical Trials
Trial Phases
Cardiac Transplant
5 Actively Recruiting
Phase 2, Phase 3, Phase 4, Not Applicable
Organ Transplantation
0 Actively Recruiting
Kidney Transplant
26 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4
Immunosuppressive Agents
1 Actively Recruiting
Phase 1

Cellcept Reviews: What are patients saying about Cellcept?

5Patient Review
5/10/2015
Cellcept for Prevention of Cardiac Transplant Rejection
I had a heart transplant five months ago and, touch wood, have not experienced any rejection yet. I attribute this largely to this medication, which I've been taking alongside Prograf and Prednisone. The side effects have been mostly minor (headache, nausea, dizziness, pimples) and I'm no longer on the Prednisone.
5Patient Review
6/26/2016
Cellcept for Diffuse Proliferative Lupus Nephritis-A Kidney Disease
I've been taking this medication for a decade now, and at 3000mg per day. I'm happy to report that my kidneys are functioning much better as a result. Blood tests show improved health in my kidneys. I still have pain and fatigue issues, but I can't imagine how much worse they would be without this drug.
5Patient Review
8/16/2015
Cellcept for Prevention of Liver Transplant Rejection
I had a double organ transplant in January 2014, and this treatment has been key to my success. I'm 20 months out and doing great!
5Patient Review
1/17/2014
Cellcept for Prevent Kidney Transplant Rejection
I unfortunately had to stop taking this RA medication after only five days due to intense headaches. I still haven't recovered from them three days later.
5Patient Review
6/13/2021
Cellcept for Liver Inflammation caused by Body's Own Immune Response
I've been taking this for six years to manage my autoimmune hepatitis and it's been working great!
4.3Patient Review
6/18/2014
Cellcept for Prevent Kidney Transplant Rejection
While it does effectively prevent rejection, there are some not-so-fun side effects that come along with this treatment. These include hair loss, sore muscles and joints, and fatigue. I've been on 1000mg twice per day since March 2014, and I'm hoping the side effects will subside over time.
4Patient Review
5/26/2014
Cellcept for Prevent of Transplant Rejection
I find that this medication can irritate my stomach if I haven't eaten anything, so it's best to take it with food.
3.3Patient Review
12/10/2013
Cellcept for Diffuse Proliferative Lupus Nephritis-A Kidney Disease
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about cellcept

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is CellCept considered a steroid?

"Mycophenolate mofetil, the main ingredient of CellCept, is one of the non-steroid medications that is being considered as an alternative to prednisone in the treatment of sarcoidosis."

Answered by AI

Is CellCept a form of chemotherapy?

"CellCept is not a chemotherapy drug. Chemotherapy drugs work by destroying all cells that are growing quickly. Thisworks in cancer treatment because cancer cells grow more quickly than normal healthy cells."

Answered by AI

What is CellCept used to treat?

"CELLCEPT is a prescription medicine used to prevent organ rejection in people who have received a kidney, heart, or liver transplant. Rejection occurs when the body's immune system views the new organ as a foreign threat and attacks it."

Answered by AI

Is CellCept a strong immunosuppressant?

"The Mycophenolate mofetil, Cellcept, is a new immunosuppressive drug that could be very helpful in treating internal medicine."

Answered by AI

Clinical Trials for Cellcept

Have you considered Cellcept clinical trials? We made a collection of clinical trials featuring Cellcept, we think they might fit your search criteria.
Have you considered Cellcept clinical trials? We made a collection of clinical trials featuring Cellcept, we think they might fit your search criteria.
Have you considered Cellcept clinical trials? We made a collection of clinical trials featuring Cellcept, we think they might fit your search criteria.
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