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Sarcoidosis Clinical Trials 2022
Sarcoidosis studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect sarcoidosis clinical trial in 2022.
Condition
Sarcoidosis
Location
Distance
10 Miles
Any
Age
Search
Clinical Trials
Sarcoidosis Clinical Trials 2022
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Efzofitimod 5 Mg/kg
for Sarcoidosis, Pulmonary
Cleveland, OH
18+
All Sexes
Phase 3
Waitlist Available
Cleveland, OH
18+
All Sexes
This is a multicenter, randomized, double-blind, placebo-controlled, study comparing the efficacy and safety of intravenous (IV) efzofitimod 3 mg/kg and 5 mg/kg versus placebo after 48 weeks of treatment. This study will enroll adults with histologically confirmed pulmonary sarcoidosis receiving stable treatment with oral corticosteroid (OCS), with or without immunosuppressant therapy.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy
for Mediastinal Diseases
Washington, United States
18+
All Sexes
Waitlist Available
Locally Advanced
Washington, United States
18+
All Sexes
We will compare endobronchial ultrasound transbronchial needle aspiration (EBUS-TBNA) with intranodal forceps biopsy (EBUS-IFB) as it relates to the rate of diagnosis of suspected sarcoidosis.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Namilumab
for Sarcoidosis
Gainesville, FL
18+
All Sexes
Phase 2
Recruiting
Gainesville, FL
18+
All Sexes
A Randomized, Double-blind, Placebo-controlled, Study with an Open-label Cohort.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Namilumab
for Sarcoidosis, Pulmonary
Minneapolis, MN
18+
All Sexes
Phase 2
Recruiting
Grade II
Minneapolis, MN
18+
All Sexes
This is a randomized, double-blind, placebo-controlled study with an open-label extension (OLE).
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Sarcoidosis Patient Assessment And Resource Companion App
for Fatigue
Charleston, SC
18+
All Sexes
Recruiting
Charleston, SC
18+
All Sexes
Fatigue is a pervasive and disabling symptom in sarcoidosis with limited treatment options. There is a significant association between heightened stress and sarcoidosis-associated fatigue. The proposed project will evaluate the usability/feasibility of a smartphone-based stress management application for the self-management of sarcoidosis-associated stress and fatigue.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
[64]Cu Macrin
for Cardiovascular Diseases
Boston, MA
18+
All Sexes
Phase 1
Recruiting
Boston, MA
18+
All Sexes
This study is evaluating whether a radioactive drug may be useful for imaging certain diseases.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
CMK389
for Sarcoidosis, Pulmonary
New York, NY
18+
All Sexes
Phase 2
Recruiting
Stage II
New York, NY
18+
All Sexes
This study is evaluating whether a drug may help treat chronic pulmonary sarcoidosis.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Anakinra
for Sarcoidosis
Ann Arbor, MI
18+
All Sexes
Phase 2
Recruiting
Ann Arbor, MI
18+
All Sexes
Sarcoidosis is a heterogeneous disorder of unknown etiology whose signature lesions are granulomatous inflammatory infiltrates in involved tissues. Tissue commonly affected are lungs, skin, eyes, lymph nodes and the heart. In this latter case, cardiac sarcoidosis (CS) can lead to atrioventricular (AV) blocks, ventricular arrhythmias, heart failure (HF) and sudden cardiac death. Similar to other involved organs, cardiac disease generally progresses from areas of focal inflammation to scar. However, the natural history of CS is not well characterized complicating an immediate and definitive diagnosis. The management of CS often requires multidisciplinary care teams and is challenged by data limited to small observational studies and from the high likelihood of side effects of most of the treatments currently used (eg: corticosteroids, methotrexate and TNF-alfa inhibitors). Interleukin-1 (IL-1) is the prototypical pro-inflammatory cytokine, also referred to as master regulator of the inflammatory response, involved in virtually every acute process. There is evidence that IL-1 plays a role in mouse model of sarcoidosis and human pulmonary lesions as the presence of the inflammasome in granulomas of the heart of patients with cardiac sarcoidosis, providing additional support for a role of IL-1 in the pathogenesis of CS. However, IL-1 blockade has never been evaluated as a potential therapeutic agent for cardiac sarcoidosis. In the current study, researchers aim to evaluate the safety and efficacy of IL-1 blockade with anakinra (IL-1 receptor antagonist) in patients with cardiac sarcoidosis.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Sarilumab 200 MG/1.14 ML Subcutaneous Solution [KEVZARA]_#1
for Sarcoidosis
Palo Alto, CA
18+
All Sexes
Phase 2
Waitlist Available
Stage II
Palo Alto, CA
18+
All Sexes
This study is evaluating whether a drug may help reduce symptoms of sarcoidosis.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Selexipag
for Sarcoidosis-associated Pulmonary Hypertension
London, Canada
18+
All Sexes
Phase 2
Recruiting
London, Canada
18+
All Sexes
This study is evaluating whether a drug which is already approved for one type of pulmonary hypertension may be helpful for another type of pulmonary hypertension.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Enhanced Screening Protocol For Cardiac Sarcoidosis.
for Sarcoidosis
Seattle, WA
18+
All Sexes
Recruiting
Locally Advanced
Seattle, WA
18+
All Sexes
This protocol is an unblended randomized screening trial will have consecutive patients with no suggestion of cardiac sarcoidosis according to usual screening enroll in an enhanced screening protocol. The routine clinical care is to gather patient's history of symptoms and under go an ECG. If a patient has an abnormal results in standard screening, they typically have further evaluations as part of their routine medical care. These tests might include an echocardiogram, ambulatory ECG, and advanced cardiac imaging (MRI, PET scan as per local practice). A patient that has normal results on standard screening will be randomly assigned to enhanced screening at each center. Half the patients will be randomized to usual follow-up (annual symptom assessment and ECG) and the other half will be assigned to the enhanced screening (echocardiogram and ambulatory ECG at enrollment and at 24 months). The investigators hypothesize that screening using conventional history, physical and ECG in the general sarcoidosis population, followed by appropriate advanced imaging testing, will result in the identification of a higher percentage of ascertained cardiac sarcoidosis than has been reported historically (2-5%). The investigators hypothesize that routine use of echocardiogram with strain and ambulatory ECG will identify additional patients who will have advanced imaging abnormalities or who meet criteria for cardiac sarcoidosis. The investigators further hypothesize that re-screening patients after 24 months with repeat echocardiogram and ambulatory ECG will identify additional patients with suspicion for cardiac sarcoidosis who had no abnormalities on the standard screening tests.
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Cell Free DNA
for ST Elevation Myocardial Infarction
Iowa City, IA
18+
All Sexes
Recruiting
Locally Advanced
Iowa City, IA
18+
All Sexes
Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality. Immunosuppressive therapy (IST) has been shown to reverse active myocarditis and preserve left ventricular (LV) function and in some cases improve LV function. In addition, IST can suppress arrhythmias that develop due to active myocarditis and prevent the formation of scar. The potential role of cardiac biomarkers, including brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), and cardiac troponins, in detecting active myocarditis is limited and studies have been disappointing. At present, there are no biomarkers to detect active myocarditis and the use of advanced imaging modalities (FDG-PET) for assessing and monitoring active myocarditis is not feasible or practical and is associate with high radiation exposure. As such, a biomarker that is reflective of active myocarditis and that is cardiac specific will assist physicians in assessing the presence of active myocarditis to guide therapeutic decisions and to assess response to therapy which can limit further cardiac damage. Cell free DNA (cfDNA) are fragments of genomic DNA that are released into the circulation from dying or damaged cells. It is a powerful diagnostic tool in cancer, transplant rejection and fetal medicine especially when the genomic source differs from the host. A novel technique that relies on tissue unique CpG methylation patterns can identify the tissue source of cell free DNA in an individual reflecting potential tissue injury. We will be conducting a pilot study to explore the utility of this diagnostic tool to identify granulomatous myocarditis in patients with sarcoidosis.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Inhaled Treprostinil
for Sarcoidosis
Gainesville, FL
18+
All Sexes
Phase 2
Recruiting
Gainesville, FL
18+
All Sexes
This study is evaluating whether inhaled treprostinil may help improve lung function for individuals with sarcoidosis.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Ergocalciferol
for Sarcoidosis
Dallas, TX
18+
All Sexes
Phase 4
Waitlist Available
Dallas, TX
18+
All Sexes
This study is evaluating whether vitamin-D status is associated with sarcoidosis severity.
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Methotrexate
for Sarcoidosis
Vancouver, Canada
18+
All Sexes
Phase 3
Recruiting
Locally Advanced
Vancouver, Canada
18+
All Sexes
Prospective randomized controlled trial comparing low dose Prednisone(or Prednisolone)/Methotrexate combination to standard dose Prednisone(or Prednisolone) in patients diagnosed with acute active clinically manifest cardiac sarcoidosis and not yet treated. The Investigators hypothesize that low dose Prednisone(or Prednisolone)/Methotrexate combination will be as effective as standard dose Prednisone(or Prednisolone), and result in significantly better quality of life and less toxicity than standard dose Prednisone(or Prednisolone).
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Hyperpolarized 129Xe MRI
for alpha 1-Antitrypsin Deficiency
Hamilton, Canada
18+
All Sexes
Recruiting
Hamilton, Canada
18+
All Sexes
This is a single centre exploratory study that aims to apply hyperpolarized xenon-129 (129Xe) magnetic resonance imaging (MRI) methods and measurements in individual patients with and without lung disease to better understand lung structure and function and evaluate response to therapy delivered as a part of clinical care.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Acthar Gel
for Sarcoidosis
San Francisco, CA
18+
All Sexes
Phase 4
Waitlist Available
San Francisco, CA
18+
All Sexes
This study is evaluating whether a drug called Acthar may help improve lung function and symptoms for individuals with sarcoidosis.
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
ACTHAR Gel 40 Units Twice Weekly
for Sarcoidosis
Albany, NY
18+
All Sexes
Phase 2 & 3
Waitlist Available
Albany, NY
18+
All Sexes
ACTHAR gel has efficacy in the treatment of cutaneous sarcoidosis
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
ACTHAR Gel (adrenocorticotropic Hormone)
for Sarcoidosis
Albany, NY
18+
All Sexes
Phase 2 & 3
Waitlist Available
Albany, NY
18+
All Sexes
ACTHAR Gel has activity in sarcoidosis associated hypercalciuria and calcium dysregulation.
Phase-Based Progress Estimates
3
Effectiveness
3
Safety
Roflumilast
for Sarcoidosis
Cincinnati, OH
18+
All Sexes
Phase 4
Waitlist Available
Cincinnati, OH
18+
All Sexes
Pulmonary sarcoidosis patients with fibrosis often develop recurrent episodes of bronchitis. These can lead to worsening of disease for both the short and long term. Roflumilast has been shown to reduce the number of acute bronchitis episodes in patients with COPD. Drugs similar to Roflumilast have been shown to help sarcoidosis. The current study is to determine if Roflumilast will reduce number of episodes of bronchitis and help fibrotic sarcoidosis.
1
Other Trials to Consider
[64]Cu Macrin
for Cardiovascular Diseases
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Phase 1
Recruiting
Boston, MA
18+
All Sexes
Namilumab
for Sarcoidosis, Pulmonary
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2
Recruiting
Grade II
Minneapolis, MN
18+
All Sexes
Namilumab
for Sarcoidosis
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2
Recruiting
Gainesville, FL
18+
All Sexes
Ravulizumab
for Hemoglobinuria
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Phase 3
Recruiting
Newly Diagnosed
Whittier, CA
18+
All Sexes
Sarilumab 200 MG/1.14 ML Subcutaneous Solution [KEVZARA]_#1
for Sarcoidosis
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2
Waitlist Available
Stage II
Palo Alto, CA
18+
All Sexes
Anakinra
for Sarcoidosis
Phase-Based Progress Estimates
1
Effectiveness
2
Safety
Phase 2
Recruiting
Ann Arbor, MI
18+
All Sexes
Efzofitimod 5 Mg/kg
for Sarcoidosis, Pulmonary
Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Phase 3
Waitlist Available
Cleveland, OH
18+
All Sexes
Pharmacogenomic Screening
for Psychosis, Involutional
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Waitlist Available
Tuscaloosa, AL
18+
All Sexes
Endobronchial Ultrasound-Guided Intranodal Forceps Biopsy
for Mediastinal Diseases
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Waitlist Available
Locally Advanced
Washington, United States
18+
All Sexes
Prospective Memory Intervention
for Multiple Sclerosis
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
1 Prior Treatment
Hartford, CT
18 - 65
All Sexes
Alcohol Cue Reactivity Personalized Feedback Intervention
for Alcohol Drinking
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Seattle, WA
18 - 65
All Sexes
Sarcoidosis Patient Assessment And Resource Companion App
for Fatigue
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Charleston, SC
18+
All Sexes
Enhanced Screening Protocol For Cardiac Sarcoidosis.
for Sarcoidosis
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Locally Advanced
Seattle, WA
18+
All Sexes
Cell Free DNA
for ST Elevation Myocardial Infarction
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Locally Advanced
Iowa City, IA
18+
All Sexes
Resistance Training
for Obesity
Phase-Based Progress Estimates
1
Effectiveness
1
Safety
Recruiting
Birmingham, AL
18+
All Sexes
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