Afinitor

Advance Directives, Steroid therapy, Carcinoid Tumor + 11 more

Treatment

22 FDA approvals

0 Active Studies for Afinitor

What is Afinitor

Everolimus

The Generic name of this drug

Treatment Summary

Everolimus is a medication related to Rapamycin that prevents organ rejection after transplantation. It works by inhibiting the mTORC1 protein, a protein that helps control cell growth. Unlike other mTOR inhibitors, it does not affect the mTORC2 protein.

Afinitor

is the brand name

image of different drug pills on a surface

Afinitor Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Afinitor

Everolimus

2009

59

Approved as Treatment by the FDA

Everolimus, also known as Afinitor, is approved by the FDA for 22 uses including Kidney Transplant Rejection and unresectable gastrointestinal origin Progressive Neuroendocrine Tumors .

Kidney Transplant Rejection

Used to treat Kidney Transplant Rejection in combination with Basiliximab

unresectable gastrointestinal origin Progressive Neuroendocrine Tumors

Subependymal giant cell astrocytoma, tuberous sclerosis complex

locally advanced lung origin Progressive Neuroendocrine Tumors

Tuberous Sclerosis

Neuroendocrine Tumors

Tuberous Sclerosis

Lung

metastatic lung origin Progressive Neuroendocrine Tumors

pancreatic origin Progressive Neuroendocrine Tumors

Liver Transplant Rejection

Used to treat Liver Transplant Rejection in combination with Tacrolimus

metastatic gastrointestinal origin Progressive Neuroendocrine Tumors

unresectable lung origin Progressive Neuroendocrine Tumors

locally advanced gastrointestinal origin Progressive Neuroendocrine Tumors

Advance Directives

Used to treat refractory, advanced Breast cancer in combination with Exemestane

Renal angiomyolipoma, tuberous sclerosis complex

refractory Advanced Renal Cell Carcinoma

Neuroendocrine Tumors

Neoplasm Metastasis

Neuroendocrine Tumors

Steroid therapy

Used to treat Steroid therapy in combination with Tacrolimus

Neuroendocrine Tumors

Effectiveness

How Afinitor works in the body

Everolimus is a drug that works by blocking the mTOR protein, which helps control cell growth. By blocking mTOR, everolimus stops cells from transitioning from G1 to S phase, which halts cell growth and causes cell death. This drug also reduces the expression of a protein that helps produce vascular endothelial growth factor. Inhibiting mTOR has the additional effect of reducing cell proliferation, angiogenesis, and glucose uptake.

When to interrupt dosage

The prescribed dose of Afinitor is contingent upon the diagnosed affliction, such as metastatic lung source Progressive Neuroendocrine Tumors, Heart and Advance Directives. Dosage fluctuates as per the technique of administering (e.g. Tablet or Oral) expressed in the table beneath.

Condition

Dosage

Administration

Advance Directives

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Steroid therapy

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Carcinoid Tumor

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Tuberous Sclerosis

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Tuberous Sclerosis

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Waldenstrom Macroglobulinemia

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

refractory Advanced Renal Cell Carcinoma

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Neoplasm Metastasis

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

pancreatic origin Progressive Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Lung

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Neuroendocrine Tumors

2.0 mg, , 3.0 mg, 5.0 mg, 10.0 mg, 2.5 mg, 0.25 mg, 0.5 mg, 0.75 mg, 7.5 mg, 1.0 mg

Tablet, for suspension, Oral, Tablet, for suspension - Oral, , Tablet - Oral, Tablet

Warnings

There are 20 known major drug interactions with Afinitor.

Common Afinitor Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abemaciclib

Major

The serum concentration of Abemaciclib can be increased when it is combined with Everolimus.

Abetimus

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with Abetimus.

Acteoside

Major

The risk or severity of adverse effects can be increased when Everolimus is combined with Acteoside.

Afinitor Toxicity & Overdose Risk

The amount of the drug needed to inhibit a certain biological process is 0.63 nM.

image of a doctor in a lab doing drug, clinical research

Afinitor Novel Uses: Which Conditions Have a Clinical Trial Featuring Afinitor?

16 active trials are investigating the potential of Afinitor in alleviating locally advanced lung origin Progressive Neuroendocrine Tumors, advanced Carcinoid tumor and Heart related afflictions.

Condition

Clinical Trials

Trial Phases

pancreatic origin Progressive Neuroendocrine Tumors

0 Actively Recruiting

Steroid therapy

0 Actively Recruiting

Carcinoid Tumor

0 Actively Recruiting

Tuberous Sclerosis

0 Actively Recruiting

Advance Directives

0 Actively Recruiting

refractory Advanced Renal Cell Carcinoma

0 Actively Recruiting

Tuberous Sclerosis

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Neuroendocrine Tumors

0 Actively Recruiting

Waldenstrom Macroglobulinemia

0 Actively Recruiting

Neoplasm Metastasis

0 Actively Recruiting

Lung

0 Actively Recruiting

Afinitor Reviews: What are patients saying about Afinitor?

5

Patient Review

1/30/2013

Afinitor for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

So far, this has been working well for my wife. She was diagnosed with stage IV breast cancer and tamoxifen wasn't helping, but Afinitor seems to be making a difference (the tumor has shrunk quite a bit). The side effects haven't been too bad either (just mouth sores).

5

Patient Review

12/3/2016

Afinitor for Cancer of Pancreas Islet Cells

I was part of the original trial for Afinitor over eight years ago and just recently stopped using it - it had become ineffective for my cancer. It worked well for eight years - well past my initial three month expiration date. Side effects were tolerable. The body adjusts and the severity of the side effects seemed to diminish over time.

5

Patient Review

11/6/2012

Afinitor for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

After five other chemo treatments failed, my doctor put me on Afinitor. Finally, my numbers are dropping again! The only side effects that I have experienced are a few mouth sores and nose bleeds. My hair is growing back, the neuropathy in my legs is going away and I am full of energy again. No more sitting in the chair for 3 hours every week..... just one pill a day, and a once-a-month visit to the doctor for blood work. I love this medication because it has given me back my quality of life :-)

5

Patient Review

8/17/2013

Afinitor for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

My wife and I have been battling breast cancer for over 10 years now. In 2001, we were told that the cancer had returned and spread to her spine and pelvis. We've tried many different chemo treatments, but the one that has really worked for her is Afinitor/Aromasin. When she started this treatment in March, her tumor marker was 3000. By May, it had decreased to 1200; by June, it was 651; by July, 471; and by August 292. We are amazed at how well this treatment has worked and are very grateful for the results!

4.3

Patient Review

10/17/2014

Afinitor for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

I was really struggling when I first started this medication; however, I'm glad that I pushed through because it's helped a lot. That said, I am more tired now and have experienced some mouth sores.

4

Patient Review

12/9/2012

Afinitor for Cancer Involving the Kidney Cells

I had my left kidney removed in 2011 and part of my left lung due to metastasis. I was put on Sutent, but it didn't work very well. This treatment, however, is helping to shrink the tumors in my lungs. The only side effects are a slight cough and some fatigue, which are manageable.

4

Patient Review

5/2/2011

Afinitor for Cancer Involving the Kidney Cells

So far, so good! No negative effects and my last chest x-ray showed no signs of cancer.

3.7

Patient Review

11/13/2011

Afinitor for Subependymal Giant Cell Astrocytoma associated with Tuberous Sclerosis

N/A

3.7

Patient Review

8/24/2010

Afinitor for Cancer Involving the Kidney Cells

I have mouth sores.

3.3

Patient Review

9/24/2014

Afinitor for Cancer Involving the Kidney Cells

My dad has kidney cancer and recently had his left kidney removed. He started taking Afinitor 10mg about a week ago and has experienced several side effects including a sore mouth and throat, fatigue, nosebleeds, and redness on his face. We're wondering if these are normal side effects of the medication or if they will continue as long as he takes it.

3.3

Patient Review

11/24/2015

Afinitor for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

In combination with exemestane, this drug has halted the growth of my neck lesions but hasn't shown any improvement. I have also experienced a disturbing loss of smell and taste.

2.3

Patient Review

1/7/2017

Afinitor for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

I had metastatic breast cancer and was taking Exemestane alongside this medication. After two and a half weeks, I suddenly developed severe mouth sores which made it difficult to eat, talk, or drink anything. The doctor prescribed a mouthwash, but it wasn't very helpful. I stopped taking the medication after three weeks, and the sores eventually went away on their own. My cancer markers did go down slightly while I was taking this medication.

1.7

Patient Review

3/26/2015

Afinitor for Renal Angiomyolipoma with Tuberous Sclerosis Complex

The medication stopped being effective at slowing the growth of tumors after about a year. Additionally, I developed lymphedema and iron deficiency anemia. The latter was probably caused by the medication, and required transfusions. Overall, not a great experience.

1

Patient Review

10/7/2011

Afinitor for Cancer Involving the Kidney Cells

My father used this drug for 5 months with no results, and experienced very negative side effects. I would not recommend this drug to anyone; his doctor eventually agreed and stopped the treatment.

1

Patient Review

7/31/2010

Afinitor for Cancer Involving the Kidney Cells

I started this treatment on July 12th, 2010.

1

Patient Review

3/18/2014

Afinitor for Hormone Receptor Positive Postmenopausal Advanced Breast Cancer

I found that by pushing the pill into a mini marshmallow, I could avoid severe mouth sores. This was my deciding factor in whether or not to continue taking this medication.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about afinitor

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the drug Afinitor used for?

"Everolimus is a targeted cancer drug that blocks cancer growth. It is also known by its brand name Afinitor. People with advanced breast cancer that is hormone receptor positive might take everolimus."

Answered by AI

What are the side effects of Afinitor?

"The following are symptoms of an infection: rash, feeling weak or tired, diarrhea, swelling of arms, hands, feet, ankles, face, or other parts of the body, stomach (abdominal) pain, nausea, and fever."

Answered by AI

Can afinitor shrink tumors?

"Afinitor is the only drug that has been approved by the U.S. FDA that has been shown to prolong patient survival by a few months."

Answered by AI

Is afinitor a good drug?

"Afinitor has a mixed reputation for the treatment of Breast cancer, with an average rating of 4.6 out of 10 from a total of 10 reviewers. 40% reported a positive experience, while the other 60% had a negative experience."

Answered by AI

What is the drug AFINITOR used for?

"Everolimus is a targeted cancer drug that inhibits cancer growth. It is also known by its brand name, Afinitor. You may be prescribed Everolimus if you have advanced hormone receptor positive breast cancer."

Answered by AI

What is the success rate of AFINITOR?

"The average follow up duration was 23.7 months, 37 out of 53 patients were still alive at the end of the study, and the one and two year survival rates were 90.5% and 75.4% respectively. The median progression-free survival was 18.9 months."

Answered by AI

What are the side effects of AFINITOR?

"There is a chance you may experience the following side effects: Infections, Rash, Feeling weak or tired, Diarrhea, Swelling of arms, hands, feet, ankles, face, or other parts of the body, Stomach (abdominal) pain, Nausea, and Fever."

Answered by AI

Is AFINITOR chemotherapy?

"Afinitor is a targeted therapy drug that works by inhibiting mTORs. mTORs are proteins that promote cell growth. Afinitor selectively targets cancer cells, which makes it different from chemotherapy drugs that act on all cells that are growing quickly."

Answered by AI