Study Summary
This trial is testing the safety of a new virus-based drug for brain tumors. If it is safe, they will also test what dose is most effective.
- Brain Tumor
- Oligodendroglioma
- Pylocytic/Pylomyxoid Astrocytoma
- Glioblastoma
- Astrocytoma
- Oligoastrocytoma
- Ependymoma
- Ganglioglioma
- Anaplastic Oligodendroglioma
- Cancer Brain Metastases
Treatment Effectiveness
Phase-Based Effectiveness
Study Objectives
1 Primary · 6 Secondary · Reporting Duration: Evaluated every 2 months for 1 year
Trial Safety
Phase-Based Safety
Side Effects for
Awards & Highlights
Trial Design
3 Treatment Groups
Arm C- Multiple Dose rQNestin
1 of 3
Arm A- rQNestin
1 of 3
Arm B- rQNestin+CPA
1 of 3
Experimental Treatment
62 Total Participants · 3 Treatment Groups
Primary Treatment: rQNestin · No Placebo Group · Phase 1
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 2 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:- Chiocca, E. Antonio, Hiroshi Nakashima, Kazue Kasai, Soledad A. Fernandez, and Michael Oglesbee. 2020. “Preclinical Toxicology of Rqnestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene”. Molecular Therapy - Methods & Clinical Development. Elsevier BV. doi:10.1016/j.omtm.2020.03.028.
- Otani, Yoshihiro, Ji Young Yoo, Cole T. Lewis, Samantha Chao, Jessica Swanner, Toshihiko Shimizu, Jin Muk Kang, et al.. 2022. “Notch-induced MDSC Recruitment After Ohsv Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy”. Clinical Cancer Research. American Association for Cancer Research (AACR). doi:10.1158/1078-0432.ccr-21-2347.
- E. Antonio Chiocca, MD, PhD 2017. "A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03152318.
Frequently Asked Questions
Has the FDA authorized rQNestin for usage?
"Data on rQNestin's safety and efficacy is limited, thus warranting a score of 1 according to the team at Power." - Anonymous Online Contributor
Have there been any other experimental trials involving rQNestin?
"Presently, 816 clinical studies of rQNestin are ongoing. Of those trials, 154 have reached Phase 3 and the majority are located in Philadelphia, PA; however there are 27825 sites globally conducting research with this medication." - Anonymous Online Contributor
To what diseases is rQNestin typically administered?
"rQNestin has proven to be a successful therapeutic intervention for multiple sclerosis, mixed-cell type lymphoma, and myelocytic acute leukemia." - Anonymous Online Contributor
Is this research effort presently recruiting participants?
"Clinicaltrials.gov confirms that this study is actively in search of participants, with the initial listing posted on July 18th 2017 and most recently edited October 24th 2022." - Anonymous Online Contributor
How extensive is the participant population of this clinical experiment?
"Affirmative. Clinicaltrials.gov shows that the medical study, initially listed on 18th July 2017, is currently recruiting patients and requires 62 people at two different sites to partake in this experiment." - Anonymous Online Contributor