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What is Revlimid
LenalidomideThe Generic name of this drug
Treatment SummaryLenalidomide is a prescription drug used to treat certain types of cancer, such as multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma. Lenalidomide belongs to a class of drugs called immunomodulatory imide drugs, which work by promoting malignant cell death and enhancing the body's immunity. It is usually taken orally in capsule form and is only available under a special restricted distribution program. Lenalidomide is much safer and more effective than its predecessor, thalidomide, and has fewer side effects and toxic
Revlimidis the brand name
Revlimid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Revlimid
Lenalidomide
2005
70
Approved as Treatment by the FDA
Lenalidomide, also known as Revlimid, is approved by the FDA for 10 uses which include Follicular Lymphoma and Multiple Myeloma .Follicular Lymphoma
Used to treat Follicular Lymphoma ( FL) in combination with Rituximab
Multiple Myeloma
Used to treat Multiple Myeloma (MM) in combination with Dexamethasone
Lymphoma
Used to treat Marginal Zone Lymphoma (MZL) in combination with Rituximab
at least two prior systemic chemotherapy regimens
Myelodysplastic Syndrome
previously treated
In adults whose disease has relapsed with Rituximab
Anemia
Mantle Cell Lymphoma
Relapsed and/or Refractory Lymphoma
Hemopoietic stem cell transplant
Used to treat post-autologous hematopoietic stem cell transplantation in combination with Dexamethasone
Effectiveness
How Revlimid Affects PatientsLenalidomide is a drug used to treat hematological malignancies, which are cancers of the blood and bone marrow. It works in two ways - directly and indirectly. Directly, it kills cancer cells and slows down tumor growth, while also stopping cancer cells from invading other tissues. Indirectly, it reduces inflammation by blocking pro-inflammatory proteins. It also works to strengthen the immune system by increasing T cell production and natural killer cell activity. Lenalidomide has been studied for its potential to treat other diseases such as amyotrophic lateral sclerosis (ALS).
How Revlimid works in the bodyLenalidomide has many effects on the body. It works to weaken cancer cells by breaking down molecules that help them survive and reproduce. It also decreases inflammation by slowing down the production of molecules that cause swelling and discomfort. Lenalidomide also works to prevent the spread of cancer cells by stopping the cells from sticking together and moving around the body. Lastly, it prevents tumor growth by stopping blood vessels from supplying them with nutrients.
When to interrupt dosage
The advised dose of Revlimid is contingent upon the determined condition, including Mantle Cell Lymphoma, Relapsed and/or Refractory Lymphoma and Refractory Diffuse Large B Cell Lymphoma (DLBCL). The amount of dosage relies upon the technique of delivery (e.g. Capsule - Oral or Oral) stipulated in the table beneath.Condition
Dosage
Administration
Myelodysplastic Syndrome
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
at least two prior systemic chemotherapy regimens
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Refractory Diffuse Large B Cell Lymphoma (DLBCL)
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Mantle Cell Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Follicular Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
previously treated
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Multiple Myeloma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Hemopoietic stem cell transplant
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Amyloidosis
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Relapsed and/or Refractory Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Chronic Lymphocytic Leukemia
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Anemia
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Warnings
Revlimid ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Lenalidomide may interact with Pulse Frequency
Common Revlimid Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with Acteoside.
Revlimid Toxicity & Overdose RiskThe lowest lethal dose of lenalidomide in rats is greater than 2000 mg/kg when taken by mouth and greater than 40 mg/kg when given intravenously. In humans, the lowest toxic dose is 9 mg/kg taken over 4 weeks. There have been reports of serious side effects due to lenalidomide overdosing, including risks to the fetus, low blood cell counts, blood clots, heart problems, cancer, liver damage, skin reactions, abnormal thyroid levels, and tumour flare reactions.
Revlimid Novel Uses: Which Conditions Have a Clinical Trial Featuring Revlimid?
426 active studies are currently being conducted to assess the potential of Revlimid to treat previously treated, Relapsed and/or Refractory Lymphoma and Multiple Myeloma.Condition
Clinical Trials
Trial Phases
Myelodysplastic Syndrome
118 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Early Phase 1
at least two prior systemic chemotherapy regimens
0 Actively Recruiting
Amyloidosis
1 Actively Recruiting
Not Applicable
Chronic Lymphocytic Leukemia
21 Actively Recruiting
Phase 1, Phase 2
Relapsed and/or Refractory Lymphoma
0 Actively Recruiting
Hemopoietic stem cell transplant
0 Actively Recruiting
Anemia
0 Actively Recruiting
previously treated
0 Actively Recruiting
Follicular Lymphoma
92 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable
Mantle Cell Lymphoma
97 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Refractory Diffuse Large B Cell Lymphoma (DLBCL)
35 Actively Recruiting
Phase 1, Phase 2, Phase 3, Early Phase 1
Lymphoma
51 Actively Recruiting
Phase 2, Phase 1, Phase 3
Multiple Myeloma
12 Actively Recruiting
Phase 2, Phase 1
Revlimid Reviews: What are patients saying about Revlimid?
5Patient Review
1/21/2014 My 90 year old husband has been on revlimid since Jan.'09 and it's working great! We've seen a significant reduction in tumors with very few side effects.
5Patient Review
7/21/2013 The only downside I've experienced is neuropathy in my feet, but it's worth it because I'm now able to walk more than four miles each day.
5Patient Review
7/28/2013 I have experienced some unfortunate side effects from this medication, including muscle cramps and worsening of my neuropathy.
5Patient Review
8/12/2014 The process of signing for the delivery while still working was a little difficult, but other than that everything went smoothly.
4.7Patient Review
8/11/2018 I've been on this drug for three years now and it has kept me alive. The downside is that I'm constantly tired and have developed neuropathy in both feet. Additionally, my skin has become thicker over time.
4.7Patient Review
8/1/2012 Even after aggressive treatment, my myeloma continued to worsen. Thankfully, this medication put me into remission within just a few months. It's now been over three years and I've only experienced minor side effects like irritable bowel syndrome and a metallic taste in my mouth.
4.7Patient Review
4/12/2012 This medication is great at lowering my white blood count.
4.7Patient Review
2/15/20124.7Patient Review
10/8/2014 This drug has been working great for me with no noticeable side effects.
4.3Patient Review
6/23/2013 I had a stem cell transplant in May of 2011 and I'm doing really well now. I've been on Revlimid since then with very few side effects. The only thing is that I get tired more easily, but it has gotten better over time.
4Patient Review
11/3/2014 I was diagnosed with MM in 2008 and have since tried stem cell transfer, CDT, Velcade, and Revlimid. The latter is the only one that has worked for me; I'm on my 32nd cycle now. That said, it does come with some not-so-great side effects like IBS and facial rash. Recently had a blood clot but thankfully that's cleared up now. All things considered, I'm doing alright.
3.3Patient Review
11/28/2012 So far, the medication has been working well for me. I'm grateful.
2.7Patient Review
2/8/20122.3Patient Review
4/11/2012Patient Q&A Section about revlimid
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What type of cancer is Revlimid used for?
"Lenalidomide is a cancer drug, also known by the brand name Revlimid, which is used to treat myeloma and blood disorders known as myelodysplastic syndromes. It may also be used as part of clinical trials for other types of cancer. When used to treat myeloma, lenalidomide is usually combined with a steroid drug called dexamethasone."
Answered by AI
What is the success rate of Revlimid?
"After patients went through tandem autologous transplants, they were given Revlimid. Out of the patients that took Revlimid, 88% achieved at least a very good partial remission and 53% achieved a complete remission. The one-year survival for these patients was 92%."
Answered by AI
Is Revlimid a high risk medication?
"If you have questions about the Lenalidomide REMS, please call 1-888-geyercorp.
The side effects of REVLIMID (lenalidomide) may be very serious, including the risk to unborn babies, the risk of low blood counts, and blood clots. There are safety considerations that you need to be aware of before taking REVLIMID. That is why REVLIMID is only available through a restricted distribution program called Lenalidomide REMS. If you have questions about the Lenalidomide REMS, please call 1-888-geyercorp."
Answered by AI
What does Revlimid do to your body?
"Cancer cells are growth-slow or growth-stop by the medicine. The medicine is also used to treat anemia which is caused by blood/bone marrow disorders (myelodysplastic syndromes-MDS). By using this medicine, patients may not need blood transfusions as often."
Answered by AI
Is Revlimid a chemotherapy?
"The drug Lenalidomide, which is also known by its brand name Revlimid, is used to treat cancer. It is specifically used to treat myeloma, which is a cancer of the blood, as well as myelodysplastic syndromes, which are disorders of the blood. Lenalidomide may also be used in clinical trials for other types of cancer. When used to treat myeloma, it is often combined with another drug called dexamethasone, which is a steroid."
Answered by AI