Revlimid

Myelodysplastic Syndrome, Hemopoietic stem cell transplant, Lymphoma + 10 more
Treatment
15 FDA approvals
20 Active Studies for Revlimid

What is Revlimid

LenalidomideThe Generic name of this drug
Treatment SummaryLenalidomide is a prescription drug used to treat certain types of cancer, such as multiple myeloma, myelodysplastic syndromes, mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma. Lenalidomide belongs to a class of drugs called immunomodulatory imide drugs, which work by promoting malignant cell death and enhancing the body's immunity. It is usually taken orally in capsule form and is only available under a special restricted distribution program. Lenalidomide is much safer and more effective than its predecessor, thalidomide, and has fewer side effects and toxic
Revlimidis the brand name
image of different drug pills on a surface
Revlimid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Revlimid
Lenalidomide
2005
70

Approved as Treatment by the FDA

Lenalidomide, also known as Revlimid, is approved by the FDA for 15 uses which include Multiple Myeloma (MM) and Transfusion-dependent Anemia .
Multiple Myeloma (MM)
Used to treat Multiple Myeloma (MM) in combination with Dexamethasone
Transfusion-dependent Anemia
Marginal Zone Lymphoma (MZL)
Used to treat Marginal Zone Lymphoma (MZL) in combination with Rituximab
Myelodysplastic Syndromes (MDS)
Mantle Cell Lymphoma (MCL)
Mantle Cell Lymphoma
Multiple Myeloma
Used to treat Multiple Myeloma (MM) in combination with Dexamethasone
Follicular Lymphoma
Used to treat Follicular Lymphoma ( FL) in combination with Rituximab
previously treated
In adults whose disease has relapsed with Rituximab
Hemopoietic stem cell transplant
Used to treat post-autologous hematopoietic stem cell transplantation in combination with Dexamethasone
Myelodysplastic Syndrome
Anemia
Lymphoma
Used to treat Marginal Zone Lymphoma (MZL) in combination with Rituximab
at least two prior systemic chemotherapy regimens
Lymphoma

Effectiveness

How Revlimid Affects PatientsLenalidomide is a drug used to treat hematological malignancies, which are cancers of the blood and bone marrow. It works in two ways - directly and indirectly. Directly, it kills cancer cells and slows down tumor growth, while also stopping cancer cells from invading other tissues. Indirectly, it reduces inflammation by blocking pro-inflammatory proteins. It also works to strengthen the immune system by increasing T cell production and natural killer cell activity. Lenalidomide has been studied for its potential to treat other diseases such as amyotrophic lateral sclerosis (ALS).
How Revlimid works in the bodyLenalidomide has many effects on the body. It works to weaken cancer cells by breaking down molecules that help them survive and reproduce. It also decreases inflammation by slowing down the production of molecules that cause swelling and discomfort. Lenalidomide also works to prevent the spread of cancer cells by stopping the cells from sticking together and moving around the body. Lastly, it prevents tumor growth by stopping blood vessels from supplying them with nutrients.

When to interrupt dosage

The advised dose of Revlimid is contingent upon the determined condition, including Mantle Cell Lymphoma, Relapsed and/or Refractory Lymphoma and Refractory Diffuse Large B Cell Lymphoma (DLBCL). The amount of dosage relies upon the technique of delivery (e.g. Capsule - Oral or Oral) stipulated in the table beneath.
Condition
Dosage
Administration
Myelodysplastic Syndrome
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Hemopoietic stem cell transplant
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Chronic Lymphocytic Leukemia
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Multiple Myeloma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Lymphoma, B-Cell
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Mantle Cell Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Anemia
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
at least two prior systemic chemotherapy regimens
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
previously treated
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Follicular Lymphoma
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule
Amyloidosis
5.0 mg, 15.0 mg, 2.5 mg, 25.0 mg, 10.0 mg, 7.5 mg, , 20.0 mg
, Oral, Capsule - Oral, Capsule

Warnings

Revlimid Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Lenalidomide may interact with Pulse Frequency
There are 20 known major drug interactions with Revlimid.
Common Revlimid Drug Interactions
Drug Name
Risk Level
Description
2-Methoxyethanol
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with 2-Methoxyethanol.
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Abatacept
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with Abatacept.
Abetimus
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with Abetimus.
Acteoside
Major
The risk or severity of adverse effects can be increased when Lenalidomide is combined with Acteoside.
Revlimid Toxicity & Overdose RiskThe lowest lethal dose of lenalidomide in rats is greater than 2000 mg/kg when taken by mouth and greater than 40 mg/kg when given intravenously. In humans, the lowest toxic dose is 9 mg/kg taken over 4 weeks. There have been reports of serious side effects due to lenalidomide overdosing, including risks to the fetus, low blood cell counts, blood clots, heart problems, cancer, liver damage, skin reactions, abnormal thyroid levels, and tumour flare reactions.
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Revlimid Novel Uses: Which Conditions Have a Clinical Trial Featuring Revlimid?

426 active studies are currently being conducted to assess the potential of Revlimid to treat previously treated, Relapsed and/or Refractory Lymphoma and Multiple Myeloma.
Condition
Clinical Trials
Trial Phases
Myelodysplastic Syndrome
107 Actively Recruiting
Phase 1, Phase 2, Phase 3, Not Applicable
Lymphoma, B-Cell
37 Actively Recruiting
Phase 1, Phase 2, Phase 3, Early Phase 1
Multiple Myeloma
6 Actively Recruiting
Phase 1, Phase 2
Lymphoma
0 Actively Recruiting
Hemopoietic stem cell transplant
0 Actively Recruiting
Amyloidosis
0 Actively Recruiting
Chronic Lymphocytic Leukemia
20 Actively Recruiting
Phase 2, Phase 1
Lymphoma
39 Actively Recruiting
Phase 2, Phase 1, Phase 3, Early Phase 1, Not Applicable
Follicular Lymphoma
79 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Early Phase 1
Anemia
0 Actively Recruiting
at least two prior systemic chemotherapy regimens
0 Actively Recruiting
Mantle Cell Lymphoma
124 Actively Recruiting
Phase 2, Phase 1, Phase 3, Not Applicable, Early Phase 1
previously treated
0 Actively Recruiting

Revlimid Reviews: What are patients saying about Revlimid?

5Patient Review
1/21/2014
Revlimid for Multiple Myeloma
My 90 year old husband has been on revlimid since Jan.'09 and it's working great! We've seen a significant reduction in tumors with very few side effects.
5Patient Review
7/21/2013
Revlimid for Multiple Myeloma
The only downside I've experienced is neuropathy in my feet, but it's worth it because I'm now able to walk more than four miles each day.
5Patient Review
7/28/2013
Revlimid for Multiple Myeloma
I have experienced some unfortunate side effects from this medication, including muscle cramps and worsening of my neuropathy.
5Patient Review
8/12/2014
Revlimid for Multiple Myeloma
The process of signing for the delivery while still working was a little difficult, but other than that everything went smoothly.
4.7Patient Review
8/11/2018
Revlimid for Multiple Myeloma
I've been on this drug for three years now and it has kept me alive. The downside is that I'm constantly tired and have developed neuropathy in both feet. Additionally, my skin has become thicker over time.
View All Reviews
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Patient Q&A Section about revlimid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What type of cancer is Revlimid used for?

"Lenalidomide is a cancer drug, also known by the brand name Revlimid, which is used to treat myeloma and blood disorders known as myelodysplastic syndromes. It may also be used as part of clinical trials for other types of cancer. When used to treat myeloma, lenalidomide is usually combined with a steroid drug called dexamethasone."

Answered by AI

What is the success rate of Revlimid?

"After patients went through tandem autologous transplants, they were given Revlimid. Out of the patients that took Revlimid, 88% achieved at least a very good partial remission and 53% achieved a complete remission. The one-year survival for these patients was 92%."

Answered by AI

Is Revlimid a high risk medication?

"If you have questions about the Lenalidomide REMS, please call 1-888-geyercorp.

The side effects of REVLIMID (lenalidomide) may be very serious, including the risk to unborn babies, the risk of low blood counts, and blood clots. There are safety considerations that you need to be aware of before taking REVLIMID. That is why REVLIMID is only available through a restricted distribution program called Lenalidomide REMS. If you have questions about the Lenalidomide REMS, please call 1-888-geyercorp."

Answered by AI

What does Revlimid do to your body?

"Cancer cells are growth-slow or growth-stop by the medicine. The medicine is also used to treat anemia which is caused by blood/bone marrow disorders (myelodysplastic syndromes-MDS). By using this medicine, patients may not need blood transfusions as often."

Answered by AI

Is Revlimid a chemotherapy?

"The drug Lenalidomide, which is also known by its brand name Revlimid, is used to treat cancer. It is specifically used to treat myeloma, which is a cancer of the blood, as well as myelodysplastic syndromes, which are disorders of the blood. Lenalidomide may also be used in clinical trials for other types of cancer. When used to treat myeloma, it is often combined with another drug called dexamethasone, which is a steroid."

Answered by AI

Clinical Trials for Revlimid

Have you considered Revlimid clinical trials? We made a collection of clinical trials featuring Revlimid, we think they might fit your search criteria.
Have you considered Revlimid clinical trials? We made a collection of clinical trials featuring Revlimid, we think they might fit your search criteria.
Have you considered Revlimid clinical trials? We made a collection of clinical trials featuring Revlimid, we think they might fit your search criteria.
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