This trial is evaluating whether Lenalidomide will improve 2 primary outcomes and 4 secondary outcomes in patients with recurrent Burkitt's Lymphoma. Measurement will happen over the course of Up to 28 days.
This trial requires 102 total participants across 1 different treatment group
This trial involves a single treatment. Lenalidomide is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"It is estimated that 25,600 people will be diagnosed with lymphoma in 2030. The high number of cases at the time of diagnosis emphasizes the need for improved diagnostic accuracy and development of sensitive, specific and rapid diagnostic technologies for detection of this form of cancer and for its related clinical management." - Anonymous Online Contributor
"Lymphoma is a neoplasm (a tumor) that belongs to the category of blood cell tumors. It can occur in almost every organ that generates lymphoid cells, such as the bone marrow, the spleen, lymph nodes, and the brain. Lymphoma consists of a group of blood cancer cells that can infiltrate the bone marrow or lymph nodes, grow outside of the bone marrow, or be spread along the bloodstream to other parts of the body. Lymphoma can result in a rapid deterioration of lymph node and bone marrow cells, with symptoms of fever, weight loss, pain, swelling, and feeling tired. It is not necessarily related to cancer, although it may be. It is also not necessarily cancer." - Anonymous Online Contributor
"While lymphoma treatment seems to be evolving in a manner similar to other malignant neoplasms, with an increasing number of effective treatments and chemotherapy regimens, the long-term prognosis for these patients still remains poor. Furthermore, the survival rate, if any, from aggressive lymphoma has not really changed over the past few decades." - Anonymous Online Contributor
"Signs are frequently vague. Some of their characteristics are as follows: tender lymph nodes, swollen lymph nodes, lump in the neck, painless swelling in the mouth/cheeks, and unexplained weight loss. It is not only a symptom but the symptoms can be the first signs of lymphoma. Symptoms can be vague in lymphoma, so a good diagnosis and treatment in these cases are necessary\n" - Anonymous Online Contributor
"Most lymphomas are highly curable (95%). However, certain lymphomas are more easily cured, such as stage 0 or 1 follicular and marginal zone lymphomas, lymphomas with a high B-symptom index, indolent low-grade lymphomas, and stage 0 or 1 small lymphocytic lymphoma of MALT type (SLLT). The most feared disease, Hodgkin's disease, is not curable. Patients should therefore be informed regularly that if a lymphoma recurs after a remission of <2 yr it has a bad prognosis." - Anonymous Online Contributor
"This is one of the largest case series examining the possible risks factors for lymphoma. It does not support the hypothesis that lymphoma is related to, or a consequence of alcohol consumption." - Anonymous Online Contributor
"Lenalidomide did not prove to be more effective than a placebo for patients with previously treated relapsed/refractory indolent B-cell non-Hodgkin's lymphoma who had received 2 or more prior lines of therapy." - Anonymous Online Contributor
"Clinical trials could potentially help by providing high quality evidence for effective treatment but they also have the potential to fail by creating high expectations of benefit which may then lead to the abandonment of treatments and poor adherence. We propose that a thorough consultation of a clinician and patient is of great importance before clinical trials are contemplated." - Anonymous Online Contributor
"The survival rates in cases of high-grade NHL are lower than low-grade NHL. The survival rates in cases of diffuse-type NHL and anaplastic-type NHL are lower, while survival rates of cases with non-Hodgkin lymphoma are higher. Survival rate is higher in males than in females irrespective of NHL type. Survival rate of cases with NHL is higher than in the general population. Survival rate of cases with NHL is lower than the survival rate of the general population. Survival rate in cases of B-cell lymphoma is higher than that of T-cell lymphoma. Survival rate of cases with aggressive NHL is lower than that of late-stage NHL." - Anonymous Online Contributor
"Until recently, there has been little research published in the English language in the areas of lymphoma. Researchers have identified two major areas of research for lymphoma: (1) the biologic and genetic mechanisms of lymphomas; and (2) new approaches to treatment of lymphoma." - Anonymous Online Contributor
"Lenalidomide has evolved as a therapeutic option for the treatment of relapsed, refractory and refractory-indeterminate multiple myeloma. In a recent study, findings of ongoing trials evaluating the safety and efficacy of lenalidomide in patients with multiple myeloma are encouraging with an excellent safety profile and tolerability. summary: This article discusses the use of lenalidomide for treatment of multiple myeloma." - Anonymous Online Contributor
"The treatment of lymphoma has not evolved since the early 1930s. Chemotherapeutic agents used to treat cancers have not been improved; therefore, we had to change our standard approach to treating cancers by using more sophisticated techniques than those used to treat lymphoma as we did. What has changed is the understanding of cancers and the new drugs and techniques for treating them have increased the quality of life for patients with cancer." - Anonymous Online Contributor