Oramorph Sr

Chronic Pain, Pain, Therapeutic procedure

Treatment

3 FDA approvals

0 Active Studies for Oramorph Sr

Treatment for

Chronic Pain

What is Oramorph Sr

Morphine

The Generic name of this drug

Treatment Summary

Morphine is an opioid medication derived from poppy seeds that was first discovered in 1805. It is a powerful pain reliever, but its usage is limited due to its potential for addiction, withdrawal, and abuse. Morphine is still used today, and it is often combined with other, less strong opioids like codeine, fentanyl, methadone, hydrocodone, hydromorphone, meperidine, and oxycodone. Morphine was approved by the FDA in 1941.

Morphine Sulfate

is the brand name

Oramorph Sr Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Morphine Sulfate

Morphine

1971

459

Approved as Treatment by the FDA

Morphine, also known as Morphine Sulfate, is approved by the FDA for 3 uses including Pain, Chronic and Chronic Pain .

Pain, Chronic

Helps manage Pain, Chronic

Chronic Pain

Helps manage Pain, Chronic

Pain

Effectiveness

How Oramorph Sr Affects Patients

Morphine works by blocking the transmission of pain signals in the body, and it typically takes 6-30 minutes to start working. Taking too much morphine can cause long-term changes in the brain. Men and women respond differently to morphine, with women being more sensitive to its effects. Morphine-6-glucuronide is much weaker than regular morphine; it is 22 times less likely to cause pupil constriction.

How Oramorph Sr works in the body

Morphine-6-glucuronide, a metabolite of morphine, is responsible for most of the drug's effects. It works by activating two types of opioid receptors: mu and kappa. The mu-opioid receptor is linked to the drug's ability to affect the reward pathway in the brain and to modify the respiratory system. The kappa-opioid receptor is associated with addiction disorders.

When to interrupt dosage

The prescribed amount of Oramorph Sr is contingent upon the specified condition, such as Therapeutic procedure, Pain and Chronic Pain. The quantity of dosage can be found in the table below, contingent upon the mode of administration.

Condition

Dosage

Administration

Therapeutic procedure

10.0 mg/mL, , 20.0 mg, 50.0 mg, 60.0 mg, 30.0 mg, 10.0 mg, 80.0 mg, 100.0 mg, 200.0 mg, 0.5 mg/mL, 1.0 mg/mL, 25.0 mg/mL, 50.0 mg/mL, 3.0 mg/mL, 100.0 mg/mL, 5.0 mg, 15.0 mg, 20.0 mg/mL, 15.0 mg/mL, 5.0 mg/mL, 8.0 mg/mL, 4.0 mg/mL, 90.0 mg, 120.0 mg, 40.0 mg, 70.0 mg, 130.0 mg, 150.0 mg, 2.0 mg/mL, 45.0 mg, 75.0 mg, 25.0 mg, 40.0 mg/mL, 1.1 mg/mL, 0.1 mg/mL

Oral, Solution - Oral, Solution, , Capsule, extended release - Oral, Capsule, extended release, Epidural; Intrathecal; Intravenous, Injection, solution - Epidural; Intrathecal; Intravenous, Injection, solution, Intravenous, Injection, solution, concentrate, Injection, solution, concentrate - Intravenous, Injection, solution - Intravenous, Intravenous; Subcutaneous, Injection, solution - Intravenous; Subcutaneous, Rectal, Suppository - Rectal, Suppository, Injection, Injection - Intramuscular; Intravenous; Subcutaneous, Intramuscular; Intravenous; Subcutaneous, Injection - Intravenous, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Capsule, coated, extended release - Oral, Capsule, coated, extended release, Tablet, extended release, Tablet, extended release - Oral, Tablet, Tablet - Oral, Intrathecal; Intravenous, Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Epidural; Intramuscular; Intrathecal; Intravenous, Injection, solution - Intrathecal; Intravenous, Capsule, Solution / drops, Solution / drops - Oral, Epidural, Solution - Intramuscular; Intravenous; Subcutaneous, Solution - Intravenous; Subcutaneous, Syrup, Tincture, Tincture - Oral, Suppository, extended release, Suppository, extended release - Rectal, Intramuscular, Injection - Intramuscular, Injection, solution - Intramuscular; Intravenous, Intramuscular; Intravenous, Epidural; Intrathecal, Injection, solution - Epidural; Intrathecal, Solution, concentrate, Solution, concentrate - Oral, Liquid - Oral, Liquid, Tablet, multilayer, extended release - Oral, Tablet, multilayer, extended release, Capsule - Oral, Solution - Epidural, Epidural; Intravenous; Subcutaneous, Solution - Epidural; Intravenous; Subcutaneous, Liquid - Intramuscular; Intravenous; Subcutaneous, Liquid - Intravenous; Subcutaneous, Syrup - Oral, Solution - Intravenous, Liquid - Intravenous, Injection - Epidural; Intrathecal; Intravenous, Solution - Parenteral, Tablet, film coated, Tablet, film coated - Oral, Parenteral, Injection, lipid complex, Injection, lipid complex - Epidural, Injection - Parenteral, Intrathecal, Injection, solution - Intrathecal, Injection - Epidural; Intrathecal, Injection, solution - Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid, Epidural; Intraspinal; Intrathecal; Intravenous; Subarachnoid

Pain

Chronic Pain

Warnings

Oramorph Sr Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Morphine may interact with Pulse Frequency

Pulse Frequency

Do Not Combine

Mental Depression

Do Not Combine

Asthma

Do Not Combine

Gastrointestinal obstruction

Do Not Combine

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Oramorph Sr.

Common Oramorph Sr Drug Interactions

Drug Name

Risk Level

Description

Azelastine

Major

Morphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Brigatinib

Major

The metabolism of Brigatinib can be decreased when combined with Morphine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Morphine.

Eluxadoline

Major

The risk or severity of constipation can be increased when Morphine is combined with Eluxadoline.

Enasidenib

Major

The metabolism of Enasidenib can be decreased when combined with Morphine.

Oramorph Sr Toxicity & Overdose Risk

The lethal dose of morphine for males is 0.78µg/mL and for females it is 0.98µg/mL. Overdosing on morphine can lead to slowed breathing, sleepiness, weak muscles, cold and clammy skin, constricted pupils, and dilated pupils. Symptoms can worsen to include fluid buildup in the lungs, slow heart rate, low blood pressure, and even death. Treatment for morphine overdose includes oxygen, medication to boost blood pressure, and medication to counteract the effects of morphine.

image of a doctor in a lab doing drug, clinical research

Oramorph Sr Novel Uses: Which Conditions Have a Clinical Trial Featuring Oramorph Sr?

24 active clinical trials are currently assessing the ability of Oramorph Sr to provide therapeutic benefit, relieve Pain and ease Chronic Pain.

Condition

Clinical Trials

Trial Phases

Pain

0 Actively Recruiting

Therapeutic procedure

0 Actively Recruiting

Chronic Pain

0 Actively Recruiting

Oramorph Sr Reviews: What are patients saying about Oramorph Sr?

Patient Review

10/29/2007

Oramorph Sr for Chronic Pain

Patient Review

10/29/2007

Oramorph Sr for Neuropathic Pain

Patient Review

10/17/2008

Oramorph Sr for Severe Pain

In comparison to other drugs, this one did not work at all for me or the three other people I know who have tried it. I believe that pharmacies are switch patients to this cheaper version in order to save money, rather than provide effective care.

Patient Review

8/6/2008

Oramorph Sr for Severe Pain

I found this to be a much better option than generic morphine.

4.3

Patient Review

12/21/2007

Oramorph Sr for Chronic Pain

Patient Review

2/12/2009

Oramorph Sr for Chronic Pain

This treatment was very effective in reducing my pain levels. It took a little bit of time to get used to, but it really helped me out.

3.7

Patient Review

11/18/2008

Oramorph Sr for Chronic Pain

This medication is very effective at reducing pain so that I can get on with my day. It's become a wonder drug for me and my back has never felt better.

3.3

Patient Review

1/3/2009

Oramorph Sr for Chronic Pain

I was pleased that this treatment alleviated my pain.

Patient Review

10/9/2007

Oramorph Sr for Chronic Pain with Narcotic Drug Tolerance

Patient Review

2/8/2009

Oramorph Sr for Neuropathic Pain

This treatment lowers the maximum pain level I experience from a 10 to more manageable 6 or 7. The side effects are also relatively mild.