← Back to Search

Dexamethasone + Dexmedetomidine for Post-Op ACL Repair Pain (AADDCToR Trial)

Phase 4
Waitlist Available
Led By Richard Brull, MD
Research Sponsored by Women's College Hospital
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
ASA 1-3 patients
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from time of end of surgery [(hh:mm) defined as anesthesia end] up to time of hospital discharge (hh:mm) assessed in minutes up to 24 hours (e.g. surgery ends 12:00, then patient discharged from the hospital at 13:00; time to hospital discharge = 60min
Awards & highlights

AADDCToR Trial Summary

This trial studies the effects of two drugs and their combination on post-op pain relief after ACL repair.

Who is the study for?
This trial is for English-speaking individuals with a BMI under 40, who are in generally good health (ASA 1-3), and are about to undergo surgery for an Anterior Cruciate Ligament (ACL) injury.Check my eligibility
What is being tested?
The study is testing the effectiveness of two drugs, Dexamethasone and Dexmedetomidine, used alone or combined as add-ons to the Adductor Canal Block (ACB), a pain management technique after ACL repair surgery.See study design
What are the potential side effects?
Possible side effects from Dexamethasone include increased blood sugar levels, swelling, and mood changes. Dexmedetomidine may cause low blood pressure, slow heart rate, and dry mouth.

AADDCToR Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am in good to moderate health with manageable medical problems.

AADDCToR Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~evaluated at 12 and 24 hours post-surgery
This trial's timeline: 3 weeks for screening, Varies for treatment, and evaluated at 12 and 24 hours post-surgery for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Oral opioid consumption
Secondary outcome measures
Intra-operative opioid consumption
Opioid consumption
PACU opioid consumption
+10 more

AADDCToR Trial Design

4Treatment groups
Active Control
Placebo Group
Group I: Dexamethasone and DexmedetomidineActive Control3 Interventions
Freezing+dexamethasone(4mg)+dexmedetomidine(50ug) + 0.5 ml of saline
Group II: Dexamethasone vs. Control comparisonActive Control2 Interventions
Freezing + dexamethasone(4mg)+1 ml of saline
Group III: Dexmedetomidine vs. Control comparisonActive Control2 Interventions
Freezing + dexmedetomidine(50ug) + 1.5 ml of saline
Group IV: Control Group-PlaceboPlacebo Group1 Intervention
Freezing + 2ml saline

Find a Location

Who is running the clinical trial?

University Health Network, TorontoOTHER
1,476 Previous Clinical Trials
484,928 Total Patients Enrolled
Women's College HospitalLead Sponsor
101 Previous Clinical Trials
38,840 Total Patients Enrolled
1 Trials studying Anterior Cruciate Ligament Injury
204 Patients Enrolled for Anterior Cruciate Ligament Injury
Richard Brull, MDPrincipal InvestigatorWomen's College Hospital
15 Previous Clinical Trials
1,196 Total Patients Enrolled

Media Library

Dexamethasone and Dexmedetomidine Clinical Trial Eligibility Overview. Trial Name: NCT03643822 — Phase 4
Anterior Cruciate Ligament Injury Research Study Groups: Dexamethasone and Dexmedetomidine, Dexamethasone vs. Control comparison, Dexmedetomidine vs. Control comparison, Control Group-Placebo
Anterior Cruciate Ligament Injury Clinical Trial 2023: Dexamethasone and Dexmedetomidine Highlights & Side Effects. Trial Name: NCT03643822 — Phase 4
Dexamethasone and Dexmedetomidine 2023 Treatment Timeline for Medical Study. Trial Name: NCT03643822 — Phase 4

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this clinical research accept participants of a certain age or older?

"This research initiative is accepting participants aged 18 to 50 years old."

Answered by AI

How reliable are Dexamethasone and Dexmedetomidine in treating patients?

"As this treatment has been approved, Power's team assigned it a score of 3 in regards to safety on the 1-3 scale."

Answered by AI

Is there an opportunity for me to enroll in this experiment?

"To meet the study's criteria for inclusion, prospective participants must have a diagnosis of anterior cruciate ligament injury and be between 18 to 50 years old. The clinical trial is actively enrolling approximately 252 patients."

Answered by AI

What conditions are Dexamethasone and Dexmedetomidine administered to ameliorate?

"Dexamethasone and dexmedetomidine are commonly employed in the treatment of ophthalmia, sympathetic. However, they can also be beneficial for managing symptoms associated with branch retinal vein occlusion, macular edema, and communicable diseases."

Answered by AI

How many individuals are partaking in this research program?

"This clinical trial is not open for recruitment, with its last update on the 18th of October 2021. However, there are 103 trials relating to anterior cruciate ligament injury and 607 studies concerning Dexamethasone and Dexmedetomidine that are still accepting participants."

Answered by AI

Is this research program currently enrolling participants?

"This research is no longer accepting applicants. The trial was launched on February 21st 2020 and was last revised on October 18th 2021. For those looking for other studies in this field, 103 trials are currently recruiting participants with anterior cruciate ligament injury while 607 more permit the use of Dexamethasone or Dexmedetomidine as part of their protocols."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain
2020. "Adjuncts for Adductor Block: Dexamethasone,Dexmedetomidine, or Combination to Reduce Pain". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03643822.
~31 spots leftby Dec 2024
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top