Dexamethasone + Dexmedetomidine for Post-Op ACL Repair Pain
(AADDCToR Trial)
Trial Summary
Do I have to stop taking my current medications for the trial?
The trial protocol does not specify if you need to stop taking your current medications. However, if you have a history of long-term opioid use or certain medical conditions, you may not be eligible to participate.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. Please consult with the trial coordinators for guidance.
What data supports the idea that Dexamethasone + Dexmedetomidine for Post-Op ACL Repair Pain is an effective drug?
The available research shows that Dexamethasone and Dexmedetomidine can be effective in managing post-surgery pain. For example, a study on shoulder surgery found that using these drugs together prolonged the time before patients needed additional pain medication. Another study on bunion surgery showed that Dexamethasone significantly reduced pain compared to a placebo. These findings suggest that the combination of Dexamethasone and Dexmedetomidine can help reduce pain after surgery, making it a potentially effective option for Post-Op ACL Repair Pain.12345
What data supports the effectiveness of the drug combination of Dexamethasone and Dexmedetomidine for post-op ACL repair pain?
What safety data exists for using dexamethasone and dexmedetomidine in post-op pain management?
Existing safety data indicates that low-dose dexamethasone is generally safe for perioperative use, with no significant increase in surgical site infections or impaired wound healing. It is effective in reducing postoperative nausea and vomiting (PONV) and has dose-dependent effects on pain and recovery. Dexmedetomidine, when combined with dexamethasone, can shorten the time to oral morphine consumption but may cause intra-operative hypotension. Overall, the combination of dexamethasone and dexmedetomidine appears to be safe, but careful monitoring is advised due to potential side effects like hypotension.12367
Is the combination of dexamethasone and dexmedetomidine safe for post-operative pain management?
Is the drug used in the trial titled 'Dexamethasone + Dexmedetomidine for Post-Op ACL Repair Pain' a promising treatment?
How does the drug combination of dexamethasone and dexmedetomidine for post-op ACL repair pain differ from other treatments?
The combination of dexamethasone and dexmedetomidine is unique because it potentially extends pain relief after surgery by using both an anti-inflammatory steroid (dexamethasone) and a sedative with pain-relieving properties (dexmedetomidine), which may reduce the need for opioids and provide longer-lasting pain control compared to traditional treatments.13489
What is the purpose of this trial?
The aim of this multi-centered study is to evaluate the effects of two distinct Adductor Canal Block (ACB) adjuncts, dexamethasone and dexmedetomidine, and their combination, on postoperative analgesia in patients undergoing Anterior Cruciate Ligament (ACL) Repair.
Research Team
Richard Brull, MD
Principal Investigator
Women's College Hospital
Eligibility Criteria
This trial is for English-speaking individuals with a BMI under 40, who are in generally good health (ASA 1-3), and are about to undergo surgery for an Anterior Cruciate Ligament (ACL) injury.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants undergo ACL repair surgery with adductor canal block and receive either dexamethasone, dexmedetomidine, their combination, or placebo to evaluate postoperative analgesia
Immediate Postoperative Monitoring
Participants are monitored for pain relief and opioid consumption in the PACU and up to 24 hours post-surgery
Follow-up
Participants are monitored for safety, effectiveness, and complications related to the nerve block and opioid use
Treatment Details
Interventions
- Dexamethasone
- Dexmedetomidine
- Saline
Find a Clinic Near You
Who Is Running the Clinical Trial?
Women's College Hospital
Lead Sponsor
University Health Network, Toronto
Collaborator