Dermotic

Otitis Externa, Uveitis, Perianal erythema + 30 more

Treatment

3 FDA approvals

20 Active Studies for Dermotic

What is Dermotic

Fluocinolone acetonide

The Generic name of this drug

Treatment Summary

Fluocinolone acetonide is a corticosteroid that is used in topical skin treatments. It has also been studied for use in implantable devices to treat chronic conditions. Taro Pharmaceuticals received FDA approval for an implantable device containing fluocinolone acetonide in 2016.

Neo-Synalar

is the brand name

image of different drug pills on a surface

Dermotic Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Neo-Synalar

Fluocinolone acetonide

1963

93

Approved as Treatment by the FDA

Fluocinolone acetonide, otherwise called Neo-Synalar, is approved by the FDA for 3 uses like Chronic Uveitis and Uveitis .

Chronic Uveitis

Uveitis

Uveitis

Effectiveness

How Dermotic Affects Patients

Fluocinolone acetonide is a medication used to reduce inflammation. It is usually given as a tiny implant that is injected into the eye. Clinical trials have shown that the implant can reduce the risk of uveitis flares by twofold over six months when compared to not taking the medication. It may also cause a slight increase in intraocular pressure, so it is important to monitor this.

How Dermotic works in the body

Fluocinolone acetonide is a type of corticosteroid that works to reduce inflammation. It binds to the glucocorticoid receptor, which helps it move into the cell nucleus. There, it binds to other proteins and stops them from releasing arachidonic acid, which is a precursor to inflammatory mediators like prostaglandins and leukotrienes. This prevents these molecules from being released, reducing inflammation.

When to interrupt dosage

The proposed dosage of Dermotic is contingent upon the recognized condition, including Hemorrhoids, Perianal erythema and Itch. The quantity can be located in the table below, contingent on the technique of application (e.g. Kit or Emulsion - Topical).

Condition

Dosage

Administration

Skin

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Skin Inflammation caused by Bacterial Infections

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Conjunctivitis, Bacterial

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Uveitis

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Diabetic Macular Edema

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Pressure Ulcer

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Postoperative Care

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Eczema

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Dermatitis, Seborrheic

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Otitis Externa

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Uveitis

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Otitis Media

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Chronic disease

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Surgery; Ear

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

postoperative treatment

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Ear structure

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Wound Infection

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Perianal erythema

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Scab

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Itching

, 0.0001 mg/mg, 0.1 mg/mL, 0.00025 mg/mg, 0.11 mg/mL, 0.011 mg/mL, 0.0011 mg/mL, 0.01 %, 0.59 mg, 0.025 %, 0.19 mg, 0.0001 mg/mL, 0.25 mg/mL, 1.0 mg/mg, 0.18 mg, 0.625 mg/mL, 0.000003 mg/mg

, Topical, Cream, Cream - Topical, Ointment - Topical, Ointment, Solution, Solution - Topical, Kit, Oil, Oil - Topical, Auricular (otic), Oil - Auricular (otic), Kit - Topical, Solution - Auricular (otic), Shampoo, Shampoo - Topical, Implant, Implant - Intravitreal, Intravitreal, Gel - Topical, Gel, Emulsion - Topical, Emulsion, Solution / drops, Solution / drops - Auricular (otic), Intraocular, Implant - Intraocular

Warnings

Dermotic has four contraindications and should not be applied when afflicting any of the conditions indicated in the following table.

Dermotic Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Fluocinolone Acetonide may interact with conjunctiva

Mycoses

Do Not Combine

External auditory canal structure

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Fluocinolone Acetonide may interact with conjunctiva

There are 20 known major drug interactions with Dermotic.

Common Dermotic Drug Interactions

Drug Name

Risk Level

Description

2-Methoxyethanol

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 2-Methoxyethanol.

9-(N-methyl-L-isoleucine)-cyclosporin A

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.

Abatacept

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abatacept.

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Fluocinolone acetonide.

Abetimus

Major

The risk or severity of adverse effects can be increased when Fluocinolone acetonide is combined with Abetimus.

Dermotic Toxicity & Overdose Risk

There have been no studies to assess the cancer-causing potential or its effects on fertility. However, some corticosteroids have been linked to genotoxicity, but fluocinolone acetonide has not been found to be genotoxic in certain tests.

Dermotic Novel Uses: Which Conditions Have a Clinical Trial Featuring Dermotic?

97 active trials are currently investigating the potential of Dermotic oil to treat Atopic Dermatitis, Otitis Media and External Otitis.

Condition

Clinical Trials

Trial Phases

Hemorrhoids

1 Actively Recruiting

Not Applicable

Perianal erythema

0 Actively Recruiting

Eczema

0 Actively Recruiting

Blister

0 Actively Recruiting

Otitis Externa

0 Actively Recruiting

Psoriasis of the scalp

1 Actively Recruiting

Phase 4

Otitis

3 Actively Recruiting

Not Applicable

Hemorrhoids

0 Actively Recruiting

Scab

0 Actively Recruiting

Ear structure

0 Actively Recruiting

Skin

0 Actively Recruiting

Skin Diseases

0 Actively Recruiting

Fissure in Ano

0 Actively Recruiting

Postoperative Care

5 Actively Recruiting

Early Phase 1, Phase 4, Not Applicable

Wound Infection

0 Actively Recruiting

Skin Inflammation caused by Bacterial Infections

0 Actively Recruiting

Uveitis

3 Actively Recruiting

Not Applicable, Phase 3

Conjunctivitis, Bacterial

0 Actively Recruiting

Coinfection

0 Actively Recruiting

Chronic disease

0 Actively Recruiting

Dermotic Reviews: What are patients saying about Dermotic?

5

Patient Review

4/21/2008

Dermotic for Inflammation of the External Ear Resembling Eczema

Dermotic oil is the best thing I've used for my itchy ears. It works within days and I forget that I even had a problem in the first place!

5

Patient Review

8/31/2009

Dermotic for Inflammation of the External Ear Resembling Eczema

I've had itchy, scaling ears for over 50 years. This medication worked so well that I can hardly express my results! I wish one of my dozen or so previous MDs had prescribed this for me years earlier.

5

Patient Review

1/20/2010

Dermotic for Inflammation of the External Ear Resembling Eczema

I've had chronic dry, itchy ears for years that sometimes even bled. I tried every remedy my previous doctors prescribed, to no avail. Finally, I visited an E-N-T specialist who prescribed DermOtic Oil. And it works! It stopped the itching and I don't even think about my ears anymore. The oil also leaves the skin around my ear nice and soft--no more itchiness, flakiness or bleeding. I'm very satisfied with this medication as it's the only one that's worked for me so far.

5

Patient Review

1/11/2011

Dermotic for Inflammation of the External Ear Resembling Eczema

I had been dealing with incredibly itchy ears for months before I saw an ENT. He prescribed this medication, and it's worked wonders. Not only does it relieve the itch, but it also feels good and smells great!

5

Patient Review

4/16/2019

Dermotic for Inflammation of the External Ear Resembling Eczema

I had extremely itchy ears for more than a decade, which may have been from swimming in pools regularly. This medication cured me after just three applications! I haven't needed to use it in at least a month and finally feel normal again.

5

Patient Review

5/30/2011

Dermotic for Inflammation of the External Ear Resembling Eczema

I am so glad I finally tried this treatment. It worked much faster than I could have ever imagined and has completely stopped my itchy ears.

5

Patient Review

2/3/2008

Dermotic for Inflammation of the External Ear Resembling Eczema

This was perfect for when my ears felt sore from wearing hearing aids. I just used it as needed and it worked great.

5

Patient Review

12/17/2011

Dermotic for Inflammation of the External Ear Resembling Eczema

This cleared up my itchy, crusty, inflamed ears in just two days!

5

Patient Review

5/5/2012

Dermotic for Inflammation of the External Ear Resembling Eczema

This treatment worked wonders for my itchy ears. I'm so grateful to have found something that works so well and so quickly.

5

Patient Review

8/16/2015

Dermotic for Inflammation of the External Ear Resembling Eczema

This oil is super effective for me. After just one or two applications, my ear was noticeably dryer and the itching completely stopped.

3.7

Patient Review

10/24/2007

Dermotic for Inflammation of the External Ear Resembling Eczema

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dermotic

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Clinical Trials for Dermotic

Image of Johns Hopkins Bayview Medical Center in Baltimore, United States.

VR-Enhanced PMR for Post-Burn Symptoms

18+
All Sexes
Baltimore, MD

The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep disturbances, and fatigue, in adult burn survivors. The main questions it aims to answer are: * Does VR-enhanced PMR (VR-PMR) reduce chronic pain, anxiety, itch, sleep disturbances, and fatigue more effectively than standard PMR? * Is VR-PMR a feasible and acceptable self-administered home-based intervention for burn survivors? Researchers will compare two self-administered intervention conditions, VR-enhanced PMR and standard PMR, using a randomized to sequence crossover design to see if VR technology enhances the therapeutic effects of PMR on chronic symptom management in burn survivors. Participants will: * Complete home-based sessions of VR-enhanced PMR * Complete home-based sessions of standard PMR * Report symptoms such as pain, itch, anxiety, sleep disturbances, and fatigue throughout the study * Use VR equipment provided for the intervention period (during the VR-PMR arm)

Recruiting
Has No Placebo

Johns Hopkins Bayview Medical Center

Sheera Lerman Zohar, PhD

Image of University of California, Los Angeles in Los Angeles, United States.

Hemorrhoidal Artery Embolization for Hemorrhoids

18 - 90
All Sexes
Los Angeles, CA

Hemorrhoidal artery embolization (HAE) is a novel treatment for symptomatic internal hemorrhoids. HAE involves the deliberate blockage (embolization) of enlarged rectal or hemorrhoidal arteries leading to reduction of abnormal blood flow to the hemorrhoidal tissue. The aim of HAE is to the improve hemorrhoid related symptoms, especially bleeding. Initial reports of HAE have demonstrated that it both safe and effective. Following an initial clinic visit to determine trial candidacy, enrolled patients will be subsequently treated with HAE. Patients will be followed for a year with clinic follow-up visits at 1, 3, 6 and 12 months.

Recruiting
Has No Placebo

University of California, Los Angeles

Lucas Cusumano, MD

Have you considered Dermotic clinical trials?

We made a collection of clinical trials featuring Dermotic, we think they might fit your search criteria.
Go to Trials
Image of Women and Infants Hospital in Providence, United States.

Postoperative Care for Minimally Invasive Gynecologic Surgery

18+
Female
Providence, RI

The goal of this randomized controlled trial is to assess recovery in patients undergoing benign laparoscopic gynecologic surgery. The main question it aims to answer is: do liberalized postoperative restrictions improve patient recovery after laparoscopic gynecologic surgery? Researchers will compare postoperative recovery surveys from the control group (patients given standard postoperative restrictions limiting activity for 2 weeks) to the research group (patients given liberalized postoperative instructions allowing them to engage in their normal activities of daily life at their own discretion without prescribed activity restrictions) to see if liberalized postoperative restrictions improve the recovery experience. Participants will be asked to fill out a brief questionnaire at two time intervals, 1 week after surgery and 2 weeks after surgery.

Waitlist Available
Has No Placebo

Women and Infants Hospital

Christine Foley, MD

Image of The University of Alabama at Birmingham in Birmingham, United States.

Octreotide for Diabetic Macular Edema

18 - 90
All Sexes
Birmingham, AL

Treatment of diabetic retinopathy (DR) and diabetic macula edema has included panretinal photocoagulation and intra ocular injections of anti-vascular endothelial growth factors (anti-VEGF) agents and steroids. Anti-VEGF therapy is currently the first-line treatment for proliferative diabetic retinopathies; however, this approach is ineffective in more than 30% of patients with diabetic retinal complications. Available evidence shows that subcutaneous (under the skin) injection of octreotide, a somatostatin analog, has potential therapeutic benefits in proliferative diabetic retinopathy (PDR) and diabetic macula edema (DME). This study thus seeks to determine the efficacy and safety of intranasal DDM-octreotide in the treatment of diabetic macula edema in individuals that are considered to be refractory to the current therapeutic options.

Phase 1
Waitlist Available

The University of Alabama at Birmingham

Maria Grant, MD, FARVO

Image of Associated Retinal Consultants PC in Phoenix, United States.

RO7446603 + Aflibercept/Faricimab for Diabetic Macular Edema

18+
All Sexes
Phoenix, AZ

This study aims to evaluate the ocular and systemic safety, tolerability and efficacy of RO7446603 in participants with diabetic macular edema (DME). The study consists of 2 segments: Phase I (Parts 1-4) and Phase II (Part 5). Phase I investigated the safety of RO7446603 following a single and multiple intravitreal (IVT) doses as monotherapy or co-administered with IVT aflibercept or IVT faricimab (in separate injections). Phase II will investigate the safety, tolerability, pharmacokinetics (PK) and efficacy of two dose levels of RO7446603 in combination with faricimab, with the two drugs co-mixed and administered as a single IVT injection, compared to faricimab alone. The first participant was enrolled in the Phase I segment on June 22, 2022. Phase I has been completed.

Phase 1 & 2
Recruiting

Associated Retinal Consultants PC (+70 Sites)

Clinical Trials

Genentech, Inc.

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Image of St. Michael's Hospital in Toronto, Canada.

Rectal Methadone for Postoperative Pain

18 - 65
All Sexes
Toronto, Canada

Patients undergoing spinal surgery require pain control medication after their surgery. Investigators have successfully used intravenous Methadone to manage pain after surgery. However, doctors in Canada do not have the intravenous form of Methadone to prescribe to their patients. The investigators in Canada propose a pilot trial to investigate whether Methadone administered rectally could be used to manage pain after spinal surgery. The main questions are: 1. Are investigators able to recruit participants for this trial and learn from this study to plan a larger trial? 2. Does Methadone administered rectally during surgery, reduce participants' pain intensity, use less pain medication, and have a better recovery after surgery? Investigators will compare Methadone to a placebo (a look-alike substance that contains no drug) to see if Methadone works to manage pain after surgery better than the usual pain management. Participants will: * receive either Methadone or placebo during surgery. * be asked some questions about their pain during days 1 to 3 after surgery * be contacted by phone to ask about their recovery At this time, the study aims to recruit 40 participants from St. Michael's Hospital, to learn whether it will be feasible to plan a larger study.

Phase 4
Recruiting

St. Michael's Hospital

Sergio Pereira, MD PhD

Image of University of Virginia in Charlottesville, United States.

Methadone vs Remifentanil for Pain in Craniotomy Surgery

18 - 65
All Sexes
Charlottesville, VA

Postoperative pain is prevalent after intracranial surgery. Patients undergoing craniotomy are typically managed with short acting opioids to enable early and reliable post-operative neurological exam as well as avoid the risk of respiratory depression. However, a plethora of studies have shown that a majority of these patients experience moderate to severe pain in first 48 hours after surgery. Suboptimal pain control can lead to complications such as arterial hypertension and post-operative intracranial hemorrhage, and hence, increased morbidity and mortality. Intravenous (IV) methadone has a long analgesic half-life and has N-methyl-D-aspartate (NMDA) receptor antagonist and serotonin and norepinephrine reuptake inhibitor (SNRI) properties. It has previously been shown to reduce postoperative opioid requirements, postoperative nausea and vomiting (PONV), and postoperative pain scores in patients that underwent orthopedic, abdominal, complex spine, and cardiac surgery. Similar findings have been shown in obstetric patients that underwent caesarean delivery under general anesthesia as well as patients that underwent gynecologic surgery and received IV methadone intraoperatively. In a recently published retrospective study, a single intraoperative dose of IV methadone was well tolerated with lower pain scores as well as MME (oral morphine milligram equivalents) requirements for up to 72 hours after elective intracranial surgery. IV methadone has, however, never been compared with conventional management via IV remifentanil for functional recovery in patients undergoing elective intercranial surgery. The investigator's hypothesis is that intravenous (IV) methadone is non-inferior to IV remifentanil in patients who undergo elective intracranial surgery. It offers the advantage of being a single dose noninvasive analgesic modality that may contribute to decreasing MME consumption during the first 72 hours postoperatively, controlling postoperative pain, and improving quality of recovery after surgery.

Phase < 1
Waitlist Available

University of Virginia

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