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What is Zofran Odt
OndansetronThe Generic name of this drug
Treatment SummaryOndansetron is a medicine used to prevent nausea and vomiting caused by chemotherapy treatments. It works by blocking the action of serotonin, a brain chemical that can cause nausea and vomiting. It was developed in the 1980s by GlaxoSmithKline and approved by the US FDA in 1991. It is available in tablet, orally disintegrating tablet, and injection forms and can be taken as a generic drug. Recently, it has been formulated into orally soluble films that make it easy to take during vomiting.
Zofranis the brand name
Zofran Odt Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zofran
Ondansetron
1991
583
Effectiveness
How Zofran Odt Affects PatientsOndansetron is a medicine that blocks serotonin receptors in the body, stopping the vomiting reflex and reducing nausea and vomiting. It is a relatively safe drug, but can cause a slight increase in the QTc interval, a measure of electrical activity in the heart. At the highest tested dose of 32mg, this increase can last up to 4 hours but is not expected to be significant at the recommended 8mg dose. Studies have also shown that ondansetron does not affect esophageal, gastric, or small intestinal motility, or lower esophageal sphincter pressure. However, it
How Zofran Odt works in the bodyOndansetron works to block a vomiting reflex caused by the release of serotonin. This reflex is triggered by chemotherapy or radiation treatments, and can be blocked by Ondansetron's action on serotonin receptors. Ondansetron also works on serotonin receptors located in the central nervous system and peripheral nervous system to prevent emesis. It's impact on opiate-induced emesis is still being studied.
When to interrupt dosage
The suggested measure of Zofran Odt is contingent upon the mentioned circumstance, for example, Uremia, radiation therapy induced nausea and vomiting and Pharmacotherapy. The amount likewise fluctuates as per the implementation approach featured in the table beneath.Condition
Dosage
Administration
Uremia
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pruritus
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Hyperemesis Gravidarum
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
radiation therapy induced nausea and vomiting
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Warnings
Zofran Odt ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Zofran Odt Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Ondansetron.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ondansetron.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Anagrelide.
Apomorphine
Major
The risk or severity of adverse effects can be increased when Ondansetron is combined with Apomorphine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Arsenic trioxide.
Zofran Odt Toxicity & Overdose RiskTaking too much ondansetron can cause some unusual side effects, such as temporary blindness, low blood pressure, muscle and nerve problems, drowsiness, and seizures. It is not recommended to take ondansetron during pregnancy, and nursing mothers should avoid taking this drug as it can be excreted in the milk of rats. There is not enough information to provide dosage recommendations for children under 3 years old.
Zofran Odt Novel Uses: Which Conditions Have a Clinical Trial Featuring Zofran Odt?
Currently, two active trials are investigating the potential of Zofran Odt to provide relief from Nausea, Uremia and Radiation therapy induced Nausea and Vomiting.Condition
Clinical Trials
Trial Phases
Hyperemesis Gravidarum
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Nausea
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Nausea
0 Actively Recruiting
radiation therapy induced nausea and vomiting
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Pharmacotherapy
0 Actively Recruiting
Pharmacotherapy
1 Actively Recruiting
Phase 4
Uremia
0 Actively Recruiting
Nausea
2 Actively Recruiting
Not Applicable, Phase 4
Zofran Odt Reviews: What are patients saying about Zofran Odt?
5Patient Review
5/26/2013 The sinusitis medication I've been taking unfortunately made me nauseous, but Zofran was able to help with that. Additionally, the pain relievers haven't made me nauseous since.
5Patient Review
3/8/2015 I had to go to the ER due to dehydration from not being able to keep any food down. They gave me this medication through an IV, and it worked very well. I was also pleased with the taste.
5Patient Review
5/17/2015 My daughter was given this drug for severe gastroenteritis and it was the only thing that provided relief. Thank you for making her comfortable.
5Patient Review
2/25/2014 This drug was very effective in preventing sea sickness during my cruise. I didn't have any issues at all, even on the roughest day.
5Patient Review
6/7/2012 After I had a Mallory Weise tear, I was at high risk of tearing again if I kept vomiting. This medication was the only one that worked for me. It saved me!
5Patient Review
11/27/2011 Though it is expensive, this has been the most effective drug I have ever taken.
4.7Patient Review
6/19/2013 This treatment is highly effective, but unfortunately causes dizziness.
4.7Patient Review
6/19/2013 Worked well for me, but caused some dizziness.
4.7Patient Review
4/10/2010 Dr. prescribed for daughter's severe vomiting. Only needed one tablet and it stopped her vomitting right away. She was finally able to sleep and feel better
4.3Patient Review
12/7/2016 Zofran was a life saver for me. I had been vomiting and had diarrhea for days before I finally went to the ER. They gave me Zofran through an IV, and it worked immediately. I felt so much better that they sent me home with more to take as needed. Thank you so much for this medicine!
4Patient Review
5/1/2013 I took this medication after my surgery and it helped me a lot.
3.3Patient Review
11/29/2016 I got some pretty severe headaches after starting this medication. I don't usually get migraines, so this was a big surprise (and not a pleasant one).
2.7Patient Review
12/13/2018 I'm currently battling cancer and have been for a while now. Unfortunately, the nausea has been pretty bad throughout all of this. I tried Zofran in hopes that it would help, but saw little to no results.
2.3Patient Review
3/22/2018 I should have read the label before taking this medication. I passed out as a result of an arrhythmia and it has been awful ever since. My chest is tight, I'm dizzy, and having vision problems. This was only after taking the medication twice!
2Patient Review
4/6/2011 I had a very frightening adverse side effect during surgery which is listed as "Rare Side Effect" for this drug. Heart problems emerged and required medical intervention to slow my heart rate back down to normal. According to my doctor, this sort of reaction is not uncommon for those who generally have a rapid heart beat in response to products with Pseudoephedrine (Sudafed, etc). So please take care to mention any sensitivities you might have to your doctor prior to taking this medication!
1.7Patient Review
10/17/2009 I was prescribed 8mg twice daily to stop nausea and vomiting from Gastroparesis. The grape-flavored vomit didn't work for me unfortunately; it only got rid of the sick feeling in my stomach about half the time. It also gave me horrible diarrhea a few times, which was incredibly unpleasant. I'm glad I only have to take this medication for a week.
1Patient Review
12/26/2020 Unfortunately, I had an allergic reaction to this medication. My tongue started swelling and I began sweating profusely. While it may work for others, it wasn't the right choice for me.
Patient Q&A Section about zofran odt
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does ODT mean in Zofran ODT?
"Ondansetron disintegrates in your mouth, and it's used to prevent nausea and vomiting that may be caused by certain medical treatments."
Answered by AI
What is the difference between Zofran and Zofran ODT?
"ZOFRAN ODT Tablets are administered orally and dissolve on the tongue, without the need for water. Each 5 ml of ZOFRAN Oral Solution contains 4 mg of ondansetron."
Answered by AI
What is Zofran ODT prescribed for?
"This medication works by blocking a natural substance (serotonin) that causes vomiting.
This medication is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.
This medication works by blocking a natural substance (serotonin) that causes vomiting."
Answered by AI
How long does it take ODT Zofran to work?
"How long does it take for Zofran to start working?
Zofran should work pretty quickly for most people. Many people report feeling relief within about 30 minutes, and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran can last between 8 to 12 hours."
Answered by AI