Zofran Odt

Pruritus, Hyperemesis Gravidarum, Nausea + 8 more
Treatment
7 Active Studies for Zofran Odt

What is Zofran Odt

OndansetronThe Generic name of this drug
Treatment SummaryOndansetron is a medicine used to prevent nausea and vomiting caused by chemotherapy treatments. It works by blocking the action of serotonin, a brain chemical that can cause nausea and vomiting. It was developed in the 1980s by GlaxoSmithKline and approved by the US FDA in 1991. It is available in tablet, orally disintegrating tablet, and injection forms and can be taken as a generic drug. Recently, it has been formulated into orally soluble films that make it easy to take during vomiting.
Zofranis the brand name
image of different drug pills on a surface
Zofran Odt Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zofran
Ondansetron
1991
583

Effectiveness

How Zofran Odt Affects PatientsOndansetron is a medicine that blocks serotonin receptors in the body, stopping the vomiting reflex and reducing nausea and vomiting. It is a relatively safe drug, but can cause a slight increase in the QTc interval, a measure of electrical activity in the heart. At the highest tested dose of 32mg, this increase can last up to 4 hours but is not expected to be significant at the recommended 8mg dose. Studies have also shown that ondansetron does not affect esophageal, gastric, or small intestinal motility, or lower esophageal sphincter pressure. However, it
How Zofran Odt works in the bodyOndansetron works to block a vomiting reflex caused by the release of serotonin. This reflex is triggered by chemotherapy or radiation treatments, and can be blocked by Ondansetron's action on serotonin receptors. Ondansetron also works on serotonin receptors located in the central nervous system and peripheral nervous system to prevent emesis. It's impact on opiate-induced emesis is still being studied.

When to interrupt dosage

The suggested measure of Zofran Odt is contingent upon the mentioned circumstance, for example, Uremia, radiation therapy induced nausea and vomiting and Pharmacotherapy. The amount likewise fluctuates as per the implementation approach featured in the table beneath.
Condition
Dosage
Administration
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Uremia
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pruritus
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Hyperemesis Gravidarum
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
radiation therapy induced nausea and vomiting
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche

Warnings

Zofran Odt Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Zofran Odt.
Common Zofran Odt Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Ondansetron.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ondansetron.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Anagrelide.
Apomorphine
Major
The risk or severity of adverse effects can be increased when Ondansetron is combined with Apomorphine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Arsenic trioxide.
Zofran Odt Toxicity & Overdose RiskTaking too much ondansetron can cause some unusual side effects, such as temporary blindness, low blood pressure, muscle and nerve problems, drowsiness, and seizures. It is not recommended to take ondansetron during pregnancy, and nursing mothers should avoid taking this drug as it can be excreted in the milk of rats. There is not enough information to provide dosage recommendations for children under 3 years old.
image of a doctor in a lab doing drug, clinical research

Zofran Odt Novel Uses: Which Conditions Have a Clinical Trial Featuring Zofran Odt?

Currently, two active trials are investigating the potential of Zofran Odt to provide relief from Nausea, Uremia and Radiation therapy induced Nausea and Vomiting.
Condition
Clinical Trials
Trial Phases
Hyperemesis Gravidarum
0 Actively Recruiting
Nausea
0 Actively Recruiting
radiation therapy induced nausea and vomiting
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Nausea
5 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 4
Nausea
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Pharmacotherapy
0 Actively Recruiting
Uremia
0 Actively Recruiting
Pharmacotherapy
2 Actively Recruiting
Phase 4, Not Applicable
Malignant Neoplasms
0 Actively Recruiting

Zofran Odt Reviews: What are patients saying about Zofran Odt?

5Patient Review
5/26/2013
Zofran Odt for Nausea and Vomiting
The sinusitis medication I've been taking unfortunately made me nauseous, but Zofran was able to help with that. Additionally, the pain relievers haven't made me nauseous since.
5Patient Review
3/8/2015
Zofran Odt for Vomiting in Children due to Acute Gastroenteritis
I had to go to the ER due to dehydration from not being able to keep any food down. They gave me this medication through an IV, and it worked very well. I was also pleased with the taste.
5Patient Review
5/17/2015
Zofran Odt for Nausea and Vomiting
My daughter was given this drug for severe gastroenteritis and it was the only thing that provided relief. Thank you for making her comfortable.
5Patient Review
2/25/2014
Zofran Odt for Nausea and Vomiting
This drug was very effective in preventing sea sickness during my cruise. I didn't have any issues at all, even on the roughest day.
5Patient Review
6/7/2012
Zofran Odt for Nausea and Vomiting
After I had a Mallory Weise tear, I was at high risk of tearing again if I kept vomiting. This medication was the only one that worked for me. It saved me!
View All Reviews
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Patient Q&A Section about zofran odt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does ODT mean in Zofran ODT?

"Ondansetron disintegrates in your mouth, and it's used to prevent nausea and vomiting that may be caused by certain medical treatments."

Answered by AI

What is the difference between Zofran and Zofran ODT?

"ZOFRAN ODT Tablets are administered orally and dissolve on the tongue, without the need for water. Each 5 ml of ZOFRAN Oral Solution contains 4 mg of ondansetron."

Answered by AI

What is Zofran ODT prescribed for?

"This medication works by blocking a natural substance (serotonin) that causes vomiting.

This medication is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.

This medication works by blocking a natural substance (serotonin) that causes vomiting."

Answered by AI

How long does it take ODT Zofran to work?

"How long does it take for Zofran to start working?

Zofran should work pretty quickly for most people. Many people report feeling relief within about 30 minutes, and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran can last between 8 to 12 hours."

Answered by AI

Clinical Trials for Zofran Odt

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