Zofran Odt

Pruritus, Hyperemesis Gravidarum, Nausea + 8 more

Treatment

4 Active Studies for Zofran Odt

Treatment for

Pruritus

What is Zofran Odt

Ondansetron

The Generic name of this drug

Treatment Summary

Ondansetron is a medicine used to prevent nausea and vomiting caused by chemotherapy treatments. It works by blocking the action of serotonin, a brain chemical that can cause nausea and vomiting. It was developed in the 1980s by GlaxoSmithKline and approved by the US FDA in 1991. It is available in tablet, orally disintegrating tablet, and injection forms and can be taken as a generic drug. Recently, it has been formulated into orally soluble films that make it easy to take during vomiting.

Zofran

is the brand name

image of different drug pills on a surface

Zofran Odt Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Zofran

Ondansetron

1991

583

Effectiveness

How Zofran Odt Affects Patients

Ondansetron is a medicine that blocks serotonin receptors in the body, stopping the vomiting reflex and reducing nausea and vomiting. It is a relatively safe drug, but can cause a slight increase in the QTc interval, a measure of electrical activity in the heart. At the highest tested dose of 32mg, this increase can last up to 4 hours but is not expected to be significant at the recommended 8mg dose. Studies have also shown that ondansetron does not affect esophageal, gastric, or small intestinal motility, or lower esophageal sphincter pressure. However, it

How Zofran Odt works in the body

Ondansetron works to block a vomiting reflex caused by the release of serotonin. This reflex is triggered by chemotherapy or radiation treatments, and can be blocked by Ondansetron's action on serotonin receptors. Ondansetron also works on serotonin receptors located in the central nervous system and peripheral nervous system to prevent emesis. It's impact on opiate-induced emesis is still being studied.

When to interrupt dosage

The suggested measure of Zofran Odt is contingent upon the mentioned circumstance, for example, Uremia, radiation therapy induced nausea and vomiting and Pharmacotherapy. The amount likewise fluctuates as per the implementation approach featured in the table beneath.

Condition

Dosage

Administration

Pharmacotherapy

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated - Oral, Oral, Tablet, film coated, Tablet, Tablet - Oral, Solution, Solution - Oral, Tablet, orally disintegrating, Tablet, coated, Tablet, coated - Oral, Tablet, orally disintegrating - Oral, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film - Oral, Film, Injection - Intravenous, Sublingual, Troche, Troche - Sublingual, Intramuscular, Injection, solution - Intramuscular

Nausea

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Uremia

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Pharmacotherapy

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Malignant Neoplasms

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Pruritus

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Hyperemesis Gravidarum

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Nausea

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

radiation therapy induced nausea and vomiting

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Nausea

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Malignant Neoplasms

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Warnings

Zofran Odt Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Zofran Odt.

Common Zofran Odt Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Ondansetron.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Ondansetron.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Anagrelide.

Apomorphine

Major

The risk or severity of adverse effects can be increased when Ondansetron is combined with Apomorphine.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Arsenic trioxide.

Zofran Odt Toxicity & Overdose Risk

Taking too much ondansetron can cause some unusual side effects, such as temporary blindness, low blood pressure, muscle and nerve problems, drowsiness, and seizures. It is not recommended to take ondansetron during pregnancy, and nursing mothers should avoid taking this drug as it can be excreted in the milk of rats. There is not enough information to provide dosage recommendations for children under 3 years old.

image of a doctor in a lab doing drug, clinical research

Zofran Odt Novel Uses: Which Conditions Have a Clinical Trial Featuring Zofran Odt?

Currently, two active trials are investigating the potential of Zofran Odt to provide relief from Nausea, Uremia and Radiation therapy induced Nausea and Vomiting.

Condition

Clinical Trials

Trial Phases

Hyperemesis Gravidarum

0 Actively Recruiting

Nausea

0 Actively Recruiting

radiation therapy induced nausea and vomiting

0 Actively Recruiting

Malignant Neoplasms

0 Actively Recruiting

Nausea

3 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Nausea

0 Actively Recruiting

Pruritus

0 Actively Recruiting

Pharmacotherapy

0 Actively Recruiting

Uremia

0 Actively Recruiting

Pharmacotherapy

1 Actively Recruiting

Not Applicable

Malignant Neoplasms

0 Actively Recruiting

Zofran Odt Reviews: What are patients saying about Zofran Odt?

Patient Review

5/26/2013

Zofran Odt for Nausea and Vomiting

The sinusitis medication I've been taking unfortunately made me nauseous, but Zofran was able to help with that. Additionally, the pain relievers haven't made me nauseous since.

Patient Review

3/8/2015

Zofran Odt for Vomiting in Children due to Acute Gastroenteritis

I had to go to the ER due to dehydration from not being able to keep any food down. They gave me this medication through an IV, and it worked very well. I was also pleased with the taste.

Patient Review

5/17/2015

Zofran Odt for Nausea and Vomiting

My daughter was given this drug for severe gastroenteritis and it was the only thing that provided relief. Thank you for making her comfortable.

Patient Review

2/25/2014

Zofran Odt for Nausea and Vomiting

This drug was very effective in preventing sea sickness during my cruise. I didn't have any issues at all, even on the roughest day.

Patient Review

6/7/2012

Zofran Odt for Nausea and Vomiting

After I had a Mallory Weise tear, I was at high risk of tearing again if I kept vomiting. This medication was the only one that worked for me. It saved me!

Patient Review

11/27/2011

Zofran Odt for Nausea and Vomiting

Though it is expensive, this has been the most effective drug I have ever taken.

4.7

Patient Review

6/19/2013

Zofran Odt for Prevent Nausea and Vomiting from Cancer Chemotherapy

This treatment is highly effective, but unfortunately causes dizziness.

4.7

Patient Review

6/19/2013

Zofran Odt for Nausea and Vomiting caused by Cancer Drugs

Worked well for me, but caused some dizziness.

4.7

Patient Review

4/10/2010

Zofran Odt for Nausea and Vomiting

Dr. prescribed for daughter's severe vomiting. Only needed one tablet and it stopped her vomitting right away. She was finally able to sleep and feel better

4.3

Patient Review

12/7/2016

Zofran Odt for Nausea and Vomiting

Zofran was a life saver for me. I had been vomiting and had diarrhea for days before I finally went to the ER. They gave me Zofran through an IV, and it worked immediately. I felt so much better that they sent me home with more to take as needed. Thank you so much for this medicine!

Patient Review

5/1/2013

Zofran Odt for Nausea and Vomiting

I took this medication after my surgery and it helped me a lot.

3.3

Patient Review

11/29/2016

Zofran Odt for Nausea and Vomiting

I got some pretty severe headaches after starting this medication. I don't usually get migraines, so this was a big surprise (and not a pleasant one).

2.7

Patient Review

12/13/2018

Zofran Odt for Nausea and Vomiting

I'm currently battling cancer and have been for a while now. Unfortunately, the nausea has been pretty bad throughout all of this. I tried Zofran in hopes that it would help, but saw little to no results.

2.3

Patient Review

3/22/2018

Zofran Odt for Nausea and Vomiting

I should have read the label before taking this medication. I passed out as a result of an arrhythmia and it has been awful ever since. My chest is tight, I'm dizzy, and having vision problems. This was only after taking the medication twice!

Patient Review

4/6/2011

Zofran Odt for Prevent Nausea and Vomiting After Surgery

I had a very frightening adverse side effect during surgery which is listed as "Rare Side Effect" for this drug. Heart problems emerged and required medical intervention to slow my heart rate back down to normal. According to my doctor, this sort of reaction is not uncommon for those who generally have a rapid heart beat in response to products with Pseudoephedrine (Sudafed, etc). So please take care to mention any sensitivities you might have to your doctor prior to taking this medication!

1.7

Patient Review

10/17/2009

Zofran Odt for Nausea and Vomiting

I was prescribed 8mg twice daily to stop nausea and vomiting from Gastroparesis. The grape-flavored vomit didn't work for me unfortunately; it only got rid of the sick feeling in my stomach about half the time. It also gave me horrible diarrhea a few times, which was incredibly unpleasant. I'm glad I only have to take this medication for a week.

Patient Review

12/26/2020

Zofran Odt for Prevent Nausea and Vomiting After Surgery

Unfortunately, I had an allergic reaction to this medication. My tongue started swelling and I began sweating profusely. While it may work for others, it wasn't the right choice for me.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about zofran odt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What does ODT mean in Zofran ODT?

"Ondansetron disintegrates in your mouth, and it's used to prevent nausea and vomiting that may be caused by certain medical treatments."

Answered by AI

What is the difference between Zofran and Zofran ODT?

"ZOFRAN ODT Tablets are administered orally and dissolve on the tongue, without the need for water. Each 5 ml of ZOFRAN Oral Solution contains 4 mg of ondansetron."

Answered by AI

What is Zofran ODT prescribed for?

"This medication works by blocking a natural substance (serotonin) that causes vomiting.

This medication is used to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy) and radiation therapy. It is also used to prevent and treat nausea and vomiting after surgery.

This medication works by blocking a natural substance (serotonin) that causes vomiting."

Answered by AI

How long does it take ODT Zofran to work?

"How long does it take for Zofran to start working?

Zofran should work pretty quickly for most people. Many people report feeling relief within about 30 minutes, and it reaches maximum blood concentrations in about 2 hours. The effects of Zofran can last between 8 to 12 hours."

Answered by AI