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What is Ondansetron Hydrochloride
OndansetronThe Generic name of this drug
Treatment SummaryOndansetron is a drug that works by blocking certain serotonin receptors in the brain. It was approved by the FDA in 1991 and is available as a pill, a dissolving tablet, and an injection. It is used to prevent nausea and vomiting caused by chemotherapy, and has also been found to have calming and sedative effects. Recently, a new oral film form of ondansetron has been developed to make it easier for people experiencing nausea to take the medication.
Zofranis the brand name
Ondansetron Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Zofran
Ondansetron
1991
583
Effectiveness
How Ondansetron Hydrochloride Affects PatientsOndansetron blocks the serotonin 5-HT<sub>3</sub> receptors in the body that are responsible for causing nausea and vomiting. Chemotherapy drugs can release serotonin from the intestines that trigger these symptoms, and ondansetron helps to counteract this. Studies have shown that taking ondansetron can lead to a slight increase in the time it takes for electrical signals to travel through the heart, but this effect has not been seen in those taking it orally. Additionally, it has been found to have no effect on esophageal and gastric motility, lower esophageal sph
How Ondansetron Hydrochloride works in the bodyOndansetron works by blocking a reflex in the body caused by serotonin. Serotonin is a chemical released from cells in the small intestine, which can cause nausea and vomiting. Ondansetron blocks this reflex by blocking the serotonin receptors, located on neurons in the peripheral and central nervous systems. While it seems to work for post-operative and chemotherapy-induced nausea and vomiting, it is not yet known how it affects opiate-induced emesis.
When to interrupt dosage
The prescribed dosage of Ondansetron Hydrochloride is contingent upon the diagnosed condition, such as Uremia, radiation therapy-induced nausea and vomiting and Pharmacotherapy. The quantity of dosage fluctuates, contingent upon the approach of delivery enumerated in the table below.Condition
Dosage
Administration
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Uremia
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pruritus
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Hyperemesis Gravidarum
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
radiation therapy induced nausea and vomiting
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Nausea
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Malignant Neoplasms
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Pharmacotherapy
3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL
, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Solution, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Injection - Intravenous, Intramuscular, Injection, solution - Intramuscular, Film, soluble, Film, soluble - Oral, Solution - Intramuscular; Intravenous, Solution - Intravenous, Liquid, Liquid - Intravenous, Film, Film - Oral, Troche - Sublingual, Sublingual, Troche
Warnings
Ondansetron Hydrochloride ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Common Ondansetron Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Ondansetron.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Ondansetron.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Anagrelide.
Apomorphine
Major
The risk or severity of adverse effects can be increased when Ondansetron is combined with Apomorphine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Arsenic trioxide.
Ondansetron Hydrochloride Toxicity & Overdose RiskThere have been reports of some unusual side effects after taking large doses of ondansetron, such as temporary blindness, low blood pressure, and seizures. However, these reactions went away completely after treatment. Ondansetron has not been tested in pregnant women, so it is not recommended for use during pregnancy. Additionally, nursing mothers should not take ondansetron as it is not known if it is excreted in breast milk. There is also not enough information to provide dosage recommendations for children 3 years of age or younger.
Ondansetron Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Ondansetron Hydrochloride?
Two current clinical studies are investigating the potential of Ondansetron Hydrochloride in providing relief from Nausea, Uremia and Radiation Therapy induced Nausea and Vomiting.Condition
Clinical Trials
Trial Phases
Hyperemesis Gravidarum
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Nausea
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Nausea
0 Actively Recruiting
radiation therapy induced nausea and vomiting
0 Actively Recruiting
Pruritus
0 Actively Recruiting
Pharmacotherapy
0 Actively Recruiting
Pharmacotherapy
1 Actively Recruiting
Phase 4
Uremia
0 Actively Recruiting
Nausea
2 Actively Recruiting
Not Applicable, Phase 4
Ondansetron Hydrochloride Reviews: What are patients saying about Ondansetron Hydrochloride?
5Patient Review
2/21/2019 This medication has been a lifesaver since I started chemotherapy. If I forget to pick up my prescription, the nausea and vomiting get really bad; however, as soon as I take the medication, I feel so much better within a few hours.
5Patient Review
2/20/2018 Unfortunately, this medication did nothing to relieve my nausea or vomiting. I had to call my doctor and get a different prescription. Sublingual medications are not my favorite either.
5Patient Review
11/19/2021 This medication was a life saver for me. I had been trying so many different things to combat my nausea, vomiting, gas, and diarrhea, but this is the only one that actually worked! Within 15 minutes of taking it, I felt relief.
5Patient Review
2/24/2020 I had a lot of problems with my pancreas and gall bladder before starting this medication, to the point where I was throwing up several times a day. But since beginning treatment, I feel so much better.
5Patient Review
3/5/2017 I had a bout of nausea and diarrhea, for which this medication was prescribed by my doctor. It helped to calm things down somewhat, but then I experienced constipation as a result.
5Patient Review
12/31/2019 This treatment is effective.
5Patient Review
10/28/2021 I was prescribed this treatment for migraines and it really helped. It took the nausea away quickly and effectively.
5Patient Review
2/20/2018 Unfortunately, this medication did not help me with my nausea or vomiting. I had to call my doctor back and ask for something else. Sublingual medications are also not my favorite way to take medicine.
5Patient Review
8/27/2015 I was really struggling with an itchy rash, but this treatment took care of it quickly.
5Patient Review
10/28/2021 This medication was very effective at treating my migraines and accompanying nausea.
5Patient Review
11/19/2021 This medication is a life saver. I had tried everything for my nausea, vomiting, gas, and diarrhea, and this was the only thing that helped! It relieved me within 15 minutes and I'm so grateful to have found something that works for me.
5Patient Review
3/5/2017 My doctor prescribed this medication to me when I was dealing with nausea and diarrhea. It did help to calm things down, but then I ended up constipated.
5Patient Review
2/21/2019 Chemotherapy is tough, but this medication has been a big help. I find that if I forget to take it, the nausea and vomiting get really bad; however, as long as I take it regularly, I feel so much better.
5Patient Review
12/31/2019 This treatment is effective.
5Patient Review
1/4/20155Patient Review
2/12/20155Patient Review
3/24/2015 Zofran was a life saver when it came to my nausea and vomiting. It also helped me get some much needed sleep.
5Patient Review
8/27/2015 This treatment completely stopped the incessant itching I was experiencing.
5Patient Review
2/12/20155Patient Review
3/24/2015 This treatment was extremely helpful in reducing my vomiting and allowing me to get some much-needed sleep.
5Patient Review
2/24/2020 I had a lot of trouble with my pancreas and gall bladder before starting this medication. I was constantly nauseous and vomiting several times a day. But since beginning treatment, I feel so much better.
5Patient Review
1/4/20154.7Patient Review
3/8/2016 I have taken this medication several times for nausea, and it has never worked for me. Not only that, but doctors now are reluctant to prescribe anything else but this. It speeds up my heart and throws off my rhythm.
4.7Patient Review
3/8/2016 I've tried this medication several times for nausea, but it has never worked for me. Additionally, doctors now seem reluctant to prescribe anything else. This drug speeds up my heart rate and throws off my rhythm, making it not worth the effort in my opinion.
4Patient Review
7/18/2016 This drug has been a miracle for me. I have Cyclic Vomiting Syndrome, and this has really helped alleviate my symptoms.
4Patient Review
7/18/2016 This drug has been a miracle for me. I have cyclic vomiting syndrome, and this has really helped to alleviate my symptoms.
2.3Patient Review
9/30/20142.3Patient Review
9/30/20142Patient Review
2/16/2018 I'm currently undergoing chemotherapy for my lymphoma, and I've been using this medication as a preventative measure against nausea. So far, it's been working well enough that I haven't vomited at all.
2Patient Review
10/18/2015 I was prescribed this drug for gastritis but it doesn't relieve my nausea at all.
2Patient Review
2/16/2018 I have been using this medication to help with the nausea and vomiting associated with my chemotherapy treatments, and it has been working pretty well. I still feel a little queasy sometimes, but it's nothing compared to how I felt before.
2Patient Review
10/18/2015 I was prescribed this drug for gastritis, but it unfortunately does not help with my nausea symptoms.
1.7Patient Review
4/6/2015 Used this for Prostrate Cancer radiation therapy and it did a great job at preventing nausea.
1.7Patient Review
4/6/2015 Used this to combat nausea caused by Prostrate Cancer radiation therapy. It was effective, but not perfect.
Patient Q&A Section about ondansetron hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is ondansetron a painkiller?
"Zofran works by selectively blocking the action of serotonin, a naturally occurring substance in the body that may cause nausea and vomiting.
Zofran does not belong to the class of narcotic medications. Instead, it is a 5-HT3 receptor antagonist, which means that it blocks the action of serotonin. Serotonin is a naturally occurring substance in the body that can cause nausea and vomiting."
Answered by AI
What happens when you take ondansetron?
"Ondansetron prevents nausea and vomiting by blocking the action of chemicals in the body. It is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment."
Answered by AI
What is ondansetron hydrochloride used for?
"Ondansetron is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery."
Answered by AI
How do you take ondansetron hydrochloride 4 mg?
"Put the film on top of your tongue, where it will dissolve. Do not chew or swallow it. Once it is dissolved, swallow with or without water."
Answered by AI