Ondansetron Hydrochloride

Pruritus, Hyperemesis Gravidarum, Nausea + 8 more

Treatment

4 Active Studies for Ondansetron Hydrochloride

Treatment for

Pruritus

What is Ondansetron Hydrochloride

Ondansetron

The Generic name of this drug

Treatment Summary

Ondansetron is a drug that works by blocking certain serotonin receptors in the brain. It was approved by the FDA in 1991 and is available as a pill, a dissolving tablet, and an injection. It is used to prevent nausea and vomiting caused by chemotherapy, and has also been found to have calming and sedative effects. Recently, a new oral film form of ondansetron has been developed to make it easier for people experiencing nausea to take the medication.

Zofran

is the brand name

image of different drug pills on a surface

Ondansetron Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Zofran

Ondansetron

1991

583

Effectiveness

How Ondansetron Hydrochloride Affects Patients

Ondansetron blocks the serotonin 5-HT<sub>3</sub> receptors in the body that are responsible for causing nausea and vomiting. Chemotherapy drugs can release serotonin from the intestines that trigger these symptoms, and ondansetron helps to counteract this. Studies have shown that taking ondansetron can lead to a slight increase in the time it takes for electrical signals to travel through the heart, but this effect has not been seen in those taking it orally. Additionally, it has been found to have no effect on esophageal and gastric motility, lower esophageal sph

How Ondansetron Hydrochloride works in the body

Ondansetron works by blocking a reflex in the body caused by serotonin. Serotonin is a chemical released from cells in the small intestine, which can cause nausea and vomiting. Ondansetron blocks this reflex by blocking the serotonin receptors, located on neurons in the peripheral and central nervous systems. While it seems to work for post-operative and chemotherapy-induced nausea and vomiting, it is not yet known how it affects opiate-induced emesis.

When to interrupt dosage

The prescribed dosage of Ondansetron Hydrochloride is contingent upon the diagnosed condition, such as Uremia, radiation therapy-induced nausea and vomiting and Pharmacotherapy. The quantity of dosage fluctuates, contingent upon the approach of delivery enumerated in the table below.

Condition

Dosage

Administration

Pharmacotherapy

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

, Intravenous, Injection, solution, Injection, solution - Intravenous, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Tablet, film coated - Oral, Tablet, film coated, Oral, Solution - Oral, Tablet, coated, Tablet, coated - Oral, Tablet, orally disintegrating - Oral, Tablet, orally disintegrating, Film, soluble - Oral, Film, soluble, Solution - Intravenous, Tablet - Oral, Tablet, Solution, Liquid, Liquid - Intravenous, Injection - Intravenous, Sublingual, Troche, Troche - Sublingual, Intramuscular, Injection, solution - Intramuscular, Solution - Intramuscular; Intravenous, Film - Oral, Film

Nausea

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Uremia

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Pharmacotherapy

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Malignant Neoplasms

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Pruritus

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Hyperemesis Gravidarum

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Nausea

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

radiation therapy induced nausea and vomiting

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Nausea

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Malignant Neoplasms

3.2 mg/mL, , 2.0 mg/mL, 8.0 mg, 4.0 mg, 24.0 mg, 4.0 mg/mL, 0.4 mg, 16.0 mg, 2.0 mg, 8.0 mg/mL

Warnings

Ondansetron Hydrochloride Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Ondansetron Hydrochloride.

Common Ondansetron Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Ondansetron.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Ondansetron.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Anagrelide.

Apomorphine

Major

The risk or severity of adverse effects can be increased when Ondansetron is combined with Apomorphine.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Ondansetron is combined with Arsenic trioxide.

Ondansetron Hydrochloride Toxicity & Overdose Risk

There have been reports of some unusual side effects after taking large doses of ondansetron, such as temporary blindness, low blood pressure, and seizures. However, these reactions went away completely after treatment. Ondansetron has not been tested in pregnant women, so it is not recommended for use during pregnancy. Additionally, nursing mothers should not take ondansetron as it is not known if it is excreted in breast milk. There is also not enough information to provide dosage recommendations for children 3 years of age or younger.

image of a doctor in a lab doing drug, clinical research

Ondansetron Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Ondansetron Hydrochloride?

Two current clinical studies are investigating the potential of Ondansetron Hydrochloride in providing relief from Nausea, Uremia and Radiation Therapy induced Nausea and Vomiting.

Condition

Clinical Trials

Trial Phases

Hyperemesis Gravidarum

0 Actively Recruiting

Nausea

0 Actively Recruiting

radiation therapy induced nausea and vomiting

0 Actively Recruiting

Malignant Neoplasms

0 Actively Recruiting

Nausea

3 Actively Recruiting

Phase 2, Not Applicable, Phase 3

Nausea

0 Actively Recruiting

Pruritus

0 Actively Recruiting

Pharmacotherapy

0 Actively Recruiting

Uremia

0 Actively Recruiting

Pharmacotherapy

1 Actively Recruiting

Not Applicable

Malignant Neoplasms

0 Actively Recruiting

Ondansetron Hydrochloride Reviews: What are patients saying about Ondansetron Hydrochloride?

Patient Review

2/21/2019

Ondansetron Hydrochloride for Nausea and Vomiting

This medication has been a lifesaver since I started chemotherapy. If I forget to pick up my prescription, the nausea and vomiting get really bad; however, as soon as I take the medication, I feel so much better within a few hours.

Patient Review

2/20/2018

Ondansetron Hydrochloride for Prevent Nausea and Vomiting from Cancer Chemotherapy

Unfortunately, this medication did nothing to relieve my nausea or vomiting. I had to call my doctor and get a different prescription. Sublingual medications are not my favorite either.

Patient Review

11/19/2021

Ondansetron Hydrochloride for Nausea and Vomiting

This medication was a life saver for me. I had been trying so many different things to combat my nausea, vomiting, gas, and diarrhea, but this is the only one that actually worked! Within 15 minutes of taking it, I felt relief.

Patient Review

2/24/2020

Ondansetron Hydrochloride for Nausea and Vomiting

I had a lot of problems with my pancreas and gall bladder before starting this medication, to the point where I was throwing up several times a day. But since beginning treatment, I feel so much better.

Patient Review

3/5/2017

Ondansetron Hydrochloride for Prevent Nausea and Vomiting from Cancer Chemotherapy

I had a bout of nausea and diarrhea, for which this medication was prescribed by my doctor. It helped to calm things down somewhat, but then I experienced constipation as a result.

Patient Review

12/31/2019

Ondansetron Hydrochloride for Nausea and Vomiting

This treatment is effective.

Patient Review

10/28/2021

Ondansetron Hydrochloride for Nausea and Vomiting

I was prescribed this treatment for migraines and it really helped. It took the nausea away quickly and effectively.

Patient Review

2/20/2018

Ondansetron Hydrochloride for Prevent Nausea and Vomiting from Cancer Chemotherapy

Unfortunately, this medication did not help me with my nausea or vomiting. I had to call my doctor back and ask for something else. Sublingual medications are also not my favorite way to take medicine.

Patient Review

8/27/2015

Ondansetron Hydrochloride for Nausea and Vomiting

I was really struggling with an itchy rash, but this treatment took care of it quickly.

Patient Review

10/28/2021

Ondansetron Hydrochloride for Nausea and Vomiting

This medication was very effective at treating my migraines and accompanying nausea.

Patient Review

11/19/2021

Ondansetron Hydrochloride for Nausea and Vomiting

This medication is a life saver. I had tried everything for my nausea, vomiting, gas, and diarrhea, and this was the only thing that helped! It relieved me within 15 minutes and I'm so grateful to have found something that works for me.

Patient Review

3/5/2017

Ondansetron Hydrochloride for Prevent Nausea and Vomiting from Cancer Chemotherapy

My doctor prescribed this medication to me when I was dealing with nausea and diarrhea. It did help to calm things down, but then I ended up constipated.

Patient Review

2/21/2019

Ondansetron Hydrochloride for Nausea and Vomiting

Chemotherapy is tough, but this medication has been a big help. I find that if I forget to take it, the nausea and vomiting get really bad; however, as long as I take it regularly, I feel so much better.

Patient Review

12/31/2019

Ondansetron Hydrochloride for Nausea and Vomiting

This treatment is effective.

Patient Review

1/4/2015

Ondansetron Hydrochloride for Prevent Nausea and Vomiting After Surgery

Patient Review

2/12/2015

Ondansetron Hydrochloride for Prevent Nausea and Vomiting from Cancer Chemotherapy

Patient Review

3/24/2015

Ondansetron Hydrochloride for Nausea and Vomiting

Zofran was a life saver when it came to my nausea and vomiting. It also helped me get some much needed sleep.

Patient Review

8/27/2015

Ondansetron Hydrochloride for Nausea and Vomiting

This treatment completely stopped the incessant itching I was experiencing.

Patient Review

2/12/2015

Ondansetron Hydrochloride for Prevent Nausea and Vomiting from Cancer Chemotherapy

Patient Review

3/24/2015

Ondansetron Hydrochloride for Nausea and Vomiting

This treatment was extremely helpful in reducing my vomiting and allowing me to get some much-needed sleep.

Patient Review

2/24/2020

Ondansetron Hydrochloride for Nausea and Vomiting

I had a lot of trouble with my pancreas and gall bladder before starting this medication. I was constantly nauseous and vomiting several times a day. But since beginning treatment, I feel so much better.

Patient Review

1/4/2015

Ondansetron Hydrochloride for Prevent Nausea and Vomiting After Surgery

4.7

Patient Review

3/8/2016

Ondansetron Hydrochloride for Nausea and Vomiting

I have taken this medication several times for nausea, and it has never worked for me. Not only that, but doctors now are reluctant to prescribe anything else but this. It speeds up my heart and throws off my rhythm.

4.7

Patient Review

3/8/2016

Ondansetron Hydrochloride for Nausea and Vomiting

I've tried this medication several times for nausea, but it has never worked for me. Additionally, doctors now seem reluctant to prescribe anything else. This drug speeds up my heart rate and throws off my rhythm, making it not worth the effort in my opinion.

Patient Review

7/18/2016

Ondansetron Hydrochloride for Nausea and Vomiting

This drug has been a miracle for me. I have Cyclic Vomiting Syndrome, and this has really helped alleviate my symptoms.

Patient Review

7/18/2016

Ondansetron Hydrochloride for Nausea and Vomiting

This drug has been a miracle for me. I have cyclic vomiting syndrome, and this has really helped to alleviate my symptoms.

2.3

Patient Review

9/30/2014

Ondansetron Hydrochloride for Nausea and Vomiting

2.3

Patient Review

9/30/2014

Ondansetron Hydrochloride for Nausea and Vomiting

Patient Review

2/16/2018

Ondansetron Hydrochloride for Nausea and Vomiting

I'm currently undergoing chemotherapy for my lymphoma, and I've been using this medication as a preventative measure against nausea. So far, it's been working well enough that I haven't vomited at all.

Patient Review

10/18/2015

Ondansetron Hydrochloride for Nausea and Vomiting

I was prescribed this drug for gastritis but it doesn't relieve my nausea at all.

Patient Review

2/16/2018

Ondansetron Hydrochloride for Nausea and Vomiting

I have been using this medication to help with the nausea and vomiting associated with my chemotherapy treatments, and it has been working pretty well. I still feel a little queasy sometimes, but it's nothing compared to how I felt before.

Patient Review

10/18/2015

Ondansetron Hydrochloride for Nausea and Vomiting

I was prescribed this drug for gastritis, but it unfortunately does not help with my nausea symptoms.

1.7

Patient Review

4/6/2015

Ondansetron Hydrochloride for Nausea and Vomiting

Used this for Prostrate Cancer radiation therapy and it did a great job at preventing nausea.

1.7

Patient Review

4/6/2015

Ondansetron Hydrochloride for Nausea and Vomiting

Used this to combat nausea caused by Prostrate Cancer radiation therapy. It was effective, but not perfect.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about ondansetron hydrochloride

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is ondansetron a painkiller?

"Zofran works by selectively blocking the action of serotonin, a naturally occurring substance in the body that may cause nausea and vomiting.

Zofran does not belong to the class of narcotic medications. Instead, it is a 5-HT3 receptor antagonist, which means that it blocks the action of serotonin. Serotonin is a naturally occurring substance in the body that can cause nausea and vomiting."

Answered by AI

What happens when you take ondansetron?

"Ondansetron prevents nausea and vomiting by blocking the action of chemicals in the body. It is used to prevent nausea and vomiting that may be caused by surgery, cancer chemotherapy, or radiation treatment."

Answered by AI