What is Dicyclomine Hydrochloride
DicyclomineThe Generic name of this drug
Treatment SummaryDicyclomine is a medication used to treat muscle spasms in the intestines caused by functional bowel disorder and irritable bowel syndrome. It works by blocking certain receptors and inhibiting the release of histamine and bradykinin. Despite its popularity, the evidence for its effectiveness is limited, so its use is becoming less common. Dicyclomine was approved by the FDA in 1950.
Bentylis the brand name
Dicyclomine Hydrochloride Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Bentyl
Dicyclomine
1950
217
Approved as Treatment by the FDA
Dicyclomine, also known as Bentyl, is approved by the FDA for 2 uses which include Irritable Bowel Syndrome (IBS) and Intestines .Irritable Bowel Syndrome (IBS)
Intestines
Effectiveness
How Dicyclomine Hydrochloride Affects PatientsDicyclomine is a medication used to relax the muscles of the intestines. It should be taken 4 times daily, with each dose being between 20-40mg when taken orally or 10-20mg when injected. It should not be injected into the veins.
How Dicyclomine Hydrochloride works in the bodyDicyclomine works by blocking certain receptors in the body, including M1, M2, and M3 receptors. It also blocks bradykinin and histamine, which are molecules that make muscles contract. This helps to reduce spasms in the ileum, or large intestine.
When to interrupt dosage
The amount of Dicyclomine Hydrochloride is dependent upon the determined disorder, including Irritable Bowel Syndrome (IBS), gastrointestinal spasms caused by Gas and Intestines. The dosage is variable, depending on the method of delivery as seen in the following table.Condition
Dosage
Administration
Intestines
, 10.0 mg/mL, 10.0 mg, 20.6 mg, 20.0 mg/mL, 30.0 mg, 2.5 mg, 20.0 mg, 40.0 mg
, Tablet - Oral, Syrup, Oral, Injection - Intramuscular, Capsule, Liquid - Intramuscular, Solution - Oral, Intramuscular, Injection, solution - Intramuscular, Tablet, Injection, Syrup - Oral, Liquid, Capsule - Oral, Solution, Injection, solution, Tablet, extended release, Tablet, extended release - Oral, Solution - Intramuscular
Irritable Bowel Syndrome (IBS)
, 10.0 mg/mL, 10.0 mg, 20.6 mg, 20.0 mg/mL, 30.0 mg, 2.5 mg, 20.0 mg, 40.0 mg
, Tablet - Oral, Syrup, Oral, Injection - Intramuscular, Capsule, Liquid - Intramuscular, Solution - Oral, Intramuscular, Injection, solution - Intramuscular, Tablet, Injection, Syrup - Oral, Liquid, Capsule - Oral, Solution, Injection, solution, Tablet, extended release, Tablet, extended release - Oral, Solution - Intramuscular
gastrointestinal cramps caused by Gas
, 10.0 mg/mL, 10.0 mg, 20.6 mg, 20.0 mg/mL, 30.0 mg, 2.5 mg, 20.0 mg, 40.0 mg
, Tablet - Oral, Syrup, Oral, Injection - Intramuscular, Capsule, Liquid - Intramuscular, Solution - Oral, Intramuscular, Injection, solution - Intramuscular, Tablet, Injection, Syrup - Oral, Liquid, Capsule - Oral, Solution, Injection, solution, Tablet, extended release, Tablet, extended release - Oral, Solution - Intramuscular
Warnings
Dicyclomine Hydrochloride has eight contraindications, so it should not be utilized for the situations specified in the following table.Dicyclomine Hydrochloride ContraindicationsCondition
Risk Level
Notes
Arterial Occlusive Diseases
Do Not Combine
Cardiovascular Physiological Phenomena
Do Not Combine
Myasthenia Gravis
Do Not Combine
Open-angle glaucoma
Do Not Combine
Reflux Esophagitis (RE)
Do Not Combine
Uropathy Obstructive
Do Not Combine
Ulcerative Colitis
Do Not Combine
Toxoplasma Infections
Do Not Combine
Common Dicyclomine Hydrochloride Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Dicyclomine is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Dicyclomine is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Dicyclomine is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Dicyclomine is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Dicyclomine is combined with Ipratropium.
Dicyclomine Hydrochloride Toxicity & Overdose RiskSigns of an overdose of Amantadine include headache, nausea, vomiting, blurred vision, enlarged pupils, dizziness, dry mouth, difficulty swallowing, feeling more alert or energetic than usual, and dry skin. If someone has overdosed on Amantadine, they should be treated with stomach pumping, vomiting-inducing medicines, activated charcoal, sedatives for excitement, and a drug to treat muscle spasms, if necessary. The lowest toxic dose of Amantadine in mice is 625mg/kg.
Dicyclomine Hydrochloride Novel Uses: Which Conditions Have a Clinical Trial Featuring Dicyclomine Hydrochloride?
Currently, there are 5 ongoing investigations to assess the potential of Dicyclomine Hydrochloride for managing Irritable Bowel Syndrome (IBS), Intestinal issues and abdominal discomfort due to Gas formation.Condition
Clinical Trials
Trial Phases
gastrointestinal cramps caused by Gas
0 Actively Recruiting
Irritable Bowel Syndrome (IBS)
8 Actively Recruiting
Not Applicable
Intestines
0 Actively Recruiting
Dicyclomine Hydrochloride Reviews: What are patients saying about Dicyclomine Hydrochloride?
5Patient Review
12/21/2018 I've used other drugs that were more effective, but it's hard to get anything from a primary care doctor these days. Librax was better, but I was told it's no longer being made. Even Bentyl used to help with pain and spasms. The dicyclomine helps some, but not as much as some other options.
5Patient Review
6/14/2017 Dicyclomine has been an absolute lifesaver. I had been struggling with IBS for months, and then got food poisoning on top of that which completely messed up my gut. The antibiotics made things even worse. I lost a ton of weight and was vomiting almost every morning. But after just a few days of taking this medication, I started to feel so much better. It's been a gamechanger for me.
5Patient Review
8/10/2017 After being hospitalized for a colitis infection, my doctor put me on probiotics. I continued taking them after I was discharged and they really helped alleviate the pain and discomfort.
5Patient Review
3/29/20174.3Patient Review
6/5/20174Patient Review
11/18/2019 This treatment was good. It helped me feel better and relieved my symptoms.
3.3Patient Review
10/16/2017 I've been dealing with IBS-D for a few years now, and this medication is a lifesaver. It's the only thing that really helps when everything else fails. I just took a round of antibiotics and it totally threw my system off, but this helped me get back on track.
3.3Patient Review
5/9/20173Patient Review
10/4/2017 I've had IBS-D for almost a decade and, for the longest time, was only able to manage it with over-the-counter anti-diarrheal medication. However, that steadily became less effective the longer I took it. My GI doc prescribed me this medication and I only take it during severe flare-ups or when I have extreme abdominal pain. It definitely helps with the diarrhea and mostly alleviates the abdominal discomfort as well.
3Patient Review
4/29/20171Patient Review
5/13/2021 I took this treatment four times as prescribed and all it did was give me more bloating and abdominal pain. I stopped taking it two days ago and these symptoms haven't changed.
Patient Q&A Section about dicyclomine hydrochloride
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is dicyclomine a pain pill?
"Dicyclomine is a drug that is used to relieve colicky pain that is caused by intestinal muscle spasms in people who have functional bowel syndrome or irritable bowel syndrome."
Answered by AI
When should you take dicyclomine?
"You should take dicyclomine four times a day by mouth, usually before meals and at bedtime. Follow all instructions exactly as prescribed."
Answered by AI
What is use of dicyclomine hydrochloride?
"Dicyclomine is used to treat the symptoms of irritable bowel syndrome by blocking the activity of a certain natural substance in the body. It is in a class of medications called anticholinergics and relieves muscle spasms in the gastrointestinal tract."
Answered by AI
What is the side effects for dicyclomine?
"The following effects may occur: dizziness, drowsiness, lightheadedness, weakness, blurred vision, dry eyes, dry mouth, nausea, constipation, and abdominal bloating. If you experience any of these effects for an extended period of time, or if they worsen, please consult your doctor or pharmacist."
Answered by AI