Dicyclomine Hydrochloride

Irritable Bowel Syndrome, Intestines, gastrointestinal cramps caused by Gas

Treatment

4 FDA approvals

6 Active Studies for Dicyclomine Hydrochloride

Treatment for

Irritable Bowel Syndrome

What is Dicyclomine Hydrochloride

DicyclomineThe Generic name of this drug

Treatment SummaryDicyclomine is a medication used to treat muscle spasms in the intestines caused by functional bowel disorder and irritable bowel syndrome. It works by blocking certain receptors and inhibiting the release of histamine and bradykinin. Despite its popularity, the evidence for its effectiveness is limited, so its use is becoming less common. Dicyclomine was approved by the FDA in 1950.

Bentylis the brand name

image of different drug pills on a surface

Dicyclomine Hydrochloride Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Bentyl

Dicyclomine

1950

217

Approved as Treatment by the FDA

Dicyclomine, also known as Bentyl, is approved by the FDA for 4 uses which include Bowel; Functional Syndrome and Irritable Bowel Syndrome (IBS) .

Bowel; Functional Syndrome

Irritable Bowel Syndrome (IBS)

Intestines

Irritable Bowel Syndrome

Effectiveness

How Dicyclomine Hydrochloride Affects PatientsDicyclomine is a medication used to relax the muscles of the intestines. It should be taken 4 times daily, with each dose being between 20-40mg when taken orally or 10-20mg when injected. It should not be injected into the veins.

How Dicyclomine Hydrochloride works in the bodyDicyclomine works by blocking certain receptors in the body, including M1, M2, and M3 receptors. It also blocks bradykinin and histamine, which are molecules that make muscles contract. This helps to reduce spasms in the ileum, or large intestine.

When to interrupt dosage

The amount of Dicyclomine Hydrochloride is dependent upon the determined disorder, including Irritable Bowel Syndrome (IBS), gastrointestinal spasms caused by Gas and Intestines. The dosage is variable, depending on the method of delivery as seen in the following table.

Condition

Dosage

Administration

Irritable Bowel Syndrome

20.0 mg, , 10.0 mg, 10.0 mg/mL, 20.6 mg, 20.0 mg/mL, 30.0 mg, 2.5 mg, 40.0 mg

, Oral, Tablet, Tablet - Oral, Capsule, Capsule - Oral, Solution, Solution - Oral, Intramuscular, Injection, Injection - Intramuscular, Syrup, Syrup - Oral, Injection, solution, Injection, solution - Intramuscular, Solution - Intramuscular, Liquid, Liquid - Intramuscular, Tablet, extended release, Tablet, extended release - Oral

Intestines

20.0 mg, , 10.0 mg, 10.0 mg/mL, 20.6 mg, 20.0 mg/mL, 30.0 mg, 2.5 mg, 40.0 mg

gastrointestinal cramps caused by Gas

20.0 mg, , 10.0 mg, 10.0 mg/mL, 20.6 mg, 20.0 mg/mL, 30.0 mg, 2.5 mg, 40.0 mg

Warnings

Dicyclomine Hydrochloride has eight contraindications, so it should not be utilized for the situations specified in the following table.Dicyclomine Hydrochloride Contraindications

Condition

Risk Level

Notes

Myasthenia Gravis

Do Not Combine

Reflux Esophagitis (RE)

Do Not Combine

Cardiovascular Physiological Phenomena

Do Not Combine

Arterial Occlusive Diseases

Do Not Combine

Pulse Frequency

Do Not Combine

Ulcerative Colitis

Do Not Combine

Uropathy Obstructive

Do Not Combine

Open-angle glaucoma

Do Not Combine

There are 20 known major drug interactions with Dicyclomine Hydrochloride.

Common Dicyclomine Hydrochloride Drug Interactions

Drug Name

Risk Level

Description

Aclidinium

Major

The risk or severity of adverse effects can be increased when Dicyclomine is combined with Aclidinium.

Cimetropium

Major

The risk or severity of adverse effects can be increased when Dicyclomine is combined with Cimetropium.

Eluxadoline

Major

The risk or severity of constipation can be increased when Dicyclomine is combined with Eluxadoline.

Glycopyrronium

Major

The risk or severity of adverse effects can be increased when Dicyclomine is combined with Glycopyrronium.

Ipratropium

Major

The risk or severity of adverse effects can be increased when Dicyclomine is combined with Ipratropium.

Dicyclomine Hydrochloride Toxicity & Overdose RiskSigns of an overdose of Amantadine include headache, nausea, vomiting, blurred vision, enlarged pupils, dizziness, dry mouth, difficulty swallowing, feeling more alert or energetic than usual, and dry skin. If someone has overdosed on Amantadine, they should be treated with stomach pumping, vomiting-inducing medicines, activated charcoal, sedatives for excitement, and a drug to treat muscle spasms, if necessary. The lowest toxic dose of Amantadine in mice is 625mg/kg.