Evoxac

Xerostomia
Treatment
2 FDA approvals
0 Active Studies for Evoxac

What is Evoxac

CevimelineThe Generic name of this drug
Treatment SummaryCevimeline is a medication used to treat dry mouth caused by Sjögren's syndrome. It works by stimulating certain receptors in the body that help increase saliva production. It has been approved by the FDA as a safe and effective treatment for this condition.
Evoxacis the brand name
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Evoxac Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Evoxac
Cevimeline
2000
14

Approved as Treatment by the FDA

Cevimeline, also known as Evoxac, is approved by the FDA for 2 uses including Xerostomia and Sjogren's Syndrome (SS) .
Xerostomia
Sjogren's Syndrome (SS)

Effectiveness

How Evoxac Affects PatientsCevimeline is a drug that stimulates the muscarinic receptors in the body. When taken in large enough doses, it can cause certain glands (like sweat and saliva glands) to produce more, and can also change the muscle tone in the digestive and urinary systems.
How Evoxac works in the bodyCevimeline is a medication that stimulates saliva production, relieving dry mouth. It does this by activating two types of receptors in the body, the M1 and M3 receptors. The M1 receptor stimulates the secretion of fluids from glands, while the M3 receptor causes smooth muscle contraction and increased glandular secretions. These effects work together to increase saliva production, which helps reduce the symptoms of dry mouth.

When to interrupt dosage

The proposed dose of Evoxac is contingent upon the identified condition. The amount of dosage varies, in accordance with the method of administration indicated in the table below.
Condition
Dosage
Administration
Xerostomia
30.0 mg,
, Oral, Capsule, Capsule - Oral

Warnings

There are 20 known major drug interactions with Evoxac.
Common Evoxac Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Cevimeline.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Cevimeline.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Cevimeline.
Clomipramine
Major
The metabolism of Clomipramine can be decreased when combined with Cevimeline.
Clonidine
Major
The metabolism of Clonidine can be decreased when combined with Cevimeline.
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Evoxac Novel Uses: Which Conditions Have a Clinical Trial Featuring Evoxac?

8 active studies are currently underway to investigate the potential of Evoxac in mitigating Sjögren's Syndrome.
Condition
Clinical Trials
Trial Phases
Xerostomia
0 Actively Recruiting

Evoxac Reviews: What are patients saying about Evoxac?

5Patient Review
6/9/2011
Evoxac for Dry Mouth Secondary to Sjogren's Syndrome
Evoxac is a pretty effective medication, though it only lasts for about an hour. Another issue I've had is that it seems to have made my acne worse. Has anyone else experienced this side effect?
5Patient Review
7/26/2015
Evoxac for Dry Mouth Secondary to Sjogren's Syndrome
was working great for months, but then I developed an allergy to it. Caused: "Throat Swelling." Felt like I couldn't breathe and my throat was closing off. Tried it again in June 2015 and had the same reaction after a few days.
5Patient Review
10/30/2014
Evoxac for Dry Mouth Secondary to Sjogren's Syndrome
I really rely on this medication to avoid cotton mouth. When I couldn't get my refill over the weekend, I had to go without it for two days. Those were tough! This stuff is expensive, but it works like a charm.
5Patient Review
3/27/2012
Evoxac for Dry Mouth Secondary to Sjogren's Syndrome
Unfortunately, this medication gives me a lot of unwanted side effects like excessive sweating and night leg cramps.
4.7Patient Review
3/20/2012
Evoxac for Dry Mouth Secondary to Sjogren's Syndrome
I have Sjogren's Syndrome, which causes really terrible dry mouth. This medication is the only thing that helps me at all. I took it three times a day when I first started using it, and now I'm up to four pills per day. It's effective for about the first few hours, but for anyone with this condition, that relief from dry mouth is amazing!
View All Reviews
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Patient Q&A Section about evoxac

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Evoxac help dry eyes?

"Cevimeline is approved in the USA for treating symptoms of dry mouth. It is better tolerated than pilocarpine and appears to be effective in both xerostomia and keratoconjunctivitis sicca at the 30 mg dose."

Answered by AI

What are side effects of cevimeline?

"The following are symptoms of a UTI: bladder pain, bloody or cloudy urine, body aches or pain, difficult, burning, or painful urination, difficulty in breathing, dryness or soreness of the throat, ear congestion, frequent urge to urinate."

Answered by AI

How long does Evoxac last?

""This drug has helped quite a bit with my dry mouth, which is mostly from medications, although I have a + Sjogren antibody. My lip biopsy is negative for the disease.""

Answered by AI

What is the drug Evoxac used for?

"This medication is used to treat the symptoms of dry mouth due to a certain immune disease (Sjogren's syndrome). Cevimeline belongs to a class of drugs known as cholinergic agonists."

Answered by AI
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