Levo-T

Hypothyroidism, Comatose, euthyroid Goitre + 3 more
Treatment
5 FDA approvals
12 Active Studies for Levo-T

What is Levo-T

LevothyroxineThe Generic name of this drug
Treatment SummaryLevothyroxine is a synthetic hormone used to treat hypothyroidism, a condition where the thyroid gland does not make enough of the hormones T4 and T3. Symptoms of hypothyroidism include fatigue, increased heart rate, depression, dry skin and hair, muscle cramps, constipation, weight gain, memory impairment, and poor tolerance to cold temperatures. Levothyroxine replaces the hormones that the thyroid is lacking and helps the body to function normally. It is more commonly known by its brand name Synthroid. Prior to the development of levothyroxine, the main treatment for hypothyroidism was des
Thyrolaris the brand name
image of different drug pills on a surface
Levo-T Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thyrolar
Levothyroxine
1969
1177

Approved as Treatment by the FDA

Levothyroxine, also known as Thyrolar, is approved by the FDA for 5 uses including Hypothyroidism and thyrotropin dependent Thyroid cancer .
Hypothyroidism
Helps manage Hypothyroidism
thyrotropin dependent Thyroid cancer
Hypothyroidism
Helps manage Hypothyroidism
Malignant Neoplasms
euthyroid Goitre
Helps manage euthyroid Goitre

Effectiveness

How Levo-T Affects PatientsLevothyroxine is a synthetic hormone that helps keep a normal level of thyroid hormones in the body when there is a deficiency. Too much or too little of this hormone can lead to a variety of negative effects, such as changes in growth and development, cardiovascular problems, and problems with metabolism. It is important to carefully adjust the dose of levothyroxine and monitor the patient's response to avoid over-treatment. If the thyroid hormone level is too high, it can cause an increase in heart rate, tremor, and weakness. People with any kind of heart issues should take a lower dose of levothyroxine. Too much
How Levo-T works in the bodyLevothyroxine is a manmade version of thyroxine, a hormone produced by the thyroid gland. It helps to regulate metabolism, brain function and body temperature. In people with hypothyroidism, taking levothyroxine can help to relieve symptoms like slow speech, fatigue, weight gain and hair loss. Thyroid hormones work by both entering the cell nucleus and binding to genes, as well as binding to proteins on the cell surface. These actions help to regulate heart rate, cardiac output, systemic vascular resistance and other important functions. They also control angiogenesis and tumor cell proliferation.

When to interrupt dosage

The amount of Levo-T is contingent upon the diagnosed situation, such as Comatose, Edematous Fibrosclerotic Panniculopathy (Cellulite) and Adiposity. Dosage likewise varies as per the method of delivery delineated in the table below.
Condition
Dosage
Administration
Hypothyroidism
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Cellulite
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Adiposity
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
euthyroid Goitre
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Malignant Neoplasms
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Comatose
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous

Warnings

Levo-T has four contraindications, so it should be avoided if any of the conditions listed in the following table are present.Levo-T Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heart Attack
Do Not Combine
Thyrotoxicosis
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
There are 20 known major drug interactions with Levo-T.
Common Levo-T Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Levothyroxine.
Bendamustine
Major
The serum concentration of Bendamustine can be decreased when it is combined with Levothyroxine.
Berotralstat
Major
The serum concentration of Berotralstat can be decreased when it is combined with Levothyroxine.
Binimetinib
Major
The serum concentration of Binimetinib can be decreased when it is combined with Levothyroxine.
Bortezomib
Major
The serum concentration of Bortezomib can be decreased when it is combined with Levothyroxine.
Levo-T Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 20 mg/kg when administered orally. This can cause a range of symptoms similar to those seen in thyroid problems, such as weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, rapid heart rate, increased pulse and blood pressure, irregular heartbeat, shaking, insomnia, difficulty tolerating heat or fever, and menstrual changes.
image of a doctor in a lab doing drug, clinical research

Levo-T Novel Uses: Which Conditions Have a Clinical Trial Featuring Levo-T?

15 active studies are presently examining the potential of Levo-T in treating Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism and Comatose States.
Condition
Clinical Trials
Trial Phases
euthyroid Goitre
0 Actively Recruiting
Hypothyroidism
4 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable
Comatose
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Cellulite
0 Actively Recruiting
Adiposity
8 Actively Recruiting
Not Applicable, Phase 4

Levo-T Reviews: What are patients saying about Levo-T?

5Patient Review
2/22/2021
Levo-T for A Progressive Disease of the Thyroid Gland
This medication, in combination with a gluten and sugar-free diet, has helped me immensely.
5Patient Review
5/11/2020
Levo-T for Underactive Thyroid
I've only been taking this for a short while, but I'm already feeling much better. My fatigue is gone and my mental clarity has returned. This has really been a blessing.
5Patient Review
5/17/2022
Levo-T for A Progressive Disease of the Thyroid Gland
I have a long history of medication side effects. Some of them were very serious. So I resist medications until they are absolutely necessary. I am grateful to have started Levothyroxine in January with no side effects. My TSH is now within normal range. Very grateful.
5Patient Review
3/9/2021
Levo-T for Underactive Thyroid
I've been taking levothyroxine for a while now and it's been working great. I would definitely recommend it to others.
5Patient Review
9/7/2022
Levo-T for Underactive Thyroid
I was diagnosed with low thyroid in December 2021. They put me on Levoxine tablets, and my thyroid levels have significantly improved since then. I'm feeling much better overall thanks to this treatment!
View All Reviews

Patient Q&A Section about levo-t

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Levo-T the same as levothyroxine?

"This medication is used to treat low thyroid hormone levels. It is also used to prevent or treat goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer."

Answered by AI

Is Levo-T the same as SYNTHROID?

"Levoxyl and Synthroid are Levothyroxine drug brands that have the same active ingredient but different inactive ingredients."

Answered by AI

What is Levo-T used for?

"Levothyroxine treats an underactive thyroid by providing more thyroid hormone. Low thyroid hormone levels can be caused by a natural deficiency, or by damage to the thyroid gland from radiation or surgery."

Answered by AI

What does Levo mean in levothyroxine?

"It seems that the prefix "levo-" might mean "on the left side", as in levorotation (turning or twisting to the left). This is helpful to know."

Answered by AI

Clinical Trials for Levo-T

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