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What is Levo-T
LevothyroxineThe Generic name of this drug
Treatment SummaryLevothyroxine is a synthetic hormone used to treat hypothyroidism, a condition where the thyroid gland does not make enough of the hormones T4 and T3. Symptoms of hypothyroidism include fatigue, increased heart rate, depression, dry skin and hair, muscle cramps, constipation, weight gain, memory impairment, and poor tolerance to cold temperatures. Levothyroxine replaces the hormones that the thyroid is lacking and helps the body to function normally. It is more commonly known by its brand name Synthroid. Prior to the development of levothyroxine, the main treatment for hypothyroidism was des
Thyrolaris the brand name
Levo-T Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thyrolar
Levothyroxine
1969
1177
Approved as Treatment by the FDA
Levothyroxine, also known as Thyrolar, is approved by the FDA for 3 uses including Malignant Neoplasms and Hypothyroidism .Malignant Neoplasms
Hypothyroidism
Helps manage Hypothyroidism
euthyroid Goitre
Helps manage euthyroid Goitre
Effectiveness
How Levo-T Affects PatientsLevothyroxine is a synthetic hormone that helps keep a normal level of thyroid hormones in the body when there is a deficiency. Too much or too little of this hormone can lead to a variety of negative effects, such as changes in growth and development, cardiovascular problems, and problems with metabolism. It is important to carefully adjust the dose of levothyroxine and monitor the patient's response to avoid over-treatment. If the thyroid hormone level is too high, it can cause an increase in heart rate, tremor, and weakness. People with any kind of heart issues should take a lower dose of levothyroxine. Too much
How Levo-T works in the bodyLevothyroxine is a manmade version of thyroxine, a hormone produced by the thyroid gland. It helps to regulate metabolism, brain function and body temperature. In people with hypothyroidism, taking levothyroxine can help to relieve symptoms like slow speech, fatigue, weight gain and hair loss. Thyroid hormones work by both entering the cell nucleus and binding to genes, as well as binding to proteins on the cell surface. These actions help to regulate heart rate, cardiac output, systemic vascular resistance and other important functions. They also control angiogenesis and tumor cell proliferation.
When to interrupt dosage
The amount of Levo-T is contingent upon the diagnosed situation, such as Comatose, Edematous Fibrosclerotic Panniculopathy (Cellulite) and Adiposity. Dosage likewise varies as per the method of delivery delineated in the table below.Condition
Dosage
Administration
Adiposity
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
euthyroid Goitre
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Malignant Neoplasms
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Cellulite
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Hypothyroidism
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Comatose
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Topical, Tablet - Topical, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule, Capsule - Oral, Solution, Solution - Oral, Injection - Intravenous, Injection, Injection, solution - Intravenous, Injection, solution, Solution - Intramuscular; Intravenous
Warnings
Levo-T has four contraindications, so it should be avoided if any of the conditions listed in the following table are present.Levo-T ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heart Attack
Do Not Combine
untreated subclinical or overt thryrotoxicosis
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
Common Levo-T Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Levothyroxine.
Bendamustine
Major
The serum concentration of Bendamustine can be decreased when it is combined with Levothyroxine.
Berotralstat
Major
The serum concentration of Berotralstat can be decreased when it is combined with Levothyroxine.
Binimetinib
Major
The serum concentration of Binimetinib can be decreased when it is combined with Levothyroxine.
Bortezomib
Major
The serum concentration of Bortezomib can be decreased when it is combined with Levothyroxine.
Levo-T Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 20 mg/kg when administered orally. This can cause a range of symptoms similar to those seen in thyroid problems, such as weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, rapid heart rate, increased pulse and blood pressure, irregular heartbeat, shaking, insomnia, difficulty tolerating heat or fever, and menstrual changes.
Levo-T Novel Uses: Which Conditions Have a Clinical Trial Featuring Levo-T?
15 active studies are presently examining the potential of Levo-T in treating Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism and Comatose States.Condition
Clinical Trials
Trial Phases
Cellulite
0 Actively Recruiting
euthyroid Goitre
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Comatose
0 Actively Recruiting
Adiposity
7 Actively Recruiting
Not Applicable, Phase 4
Hypothyroidism
7 Actively Recruiting
Not Applicable, Phase 4, Phase 2
Levo-T Reviews: What are patients saying about Levo-T?
5Patient Review
2/22/2021 This medication, in combination with a gluten and sugar-free diet, has helped me immensely.
5Patient Review
5/11/2020 I've only been taking this for a short while, but I'm already feeling much better. My fatigue is gone and my mental clarity has returned. This has really been a blessing.
5Patient Review
5/17/2022 I have a long history of medication side effects. Some of them were very serious. So I resist medications until they are absolutely necessary. I am grateful to have started Levothyroxine in January with no side effects. My TSH is now within normal range. Very grateful.
5Patient Review
3/9/2021 I've been taking levothyroxine for a while now and it's been working great. I would definitely recommend it to others.
5Patient Review
9/7/2022 I was diagnosed with low thyroid in December 2021. They put me on Levoxine tablets, and my thyroid levels have significantly improved since then. I'm feeling much better overall thanks to this treatment!
5Patient Review
5/11/2020 I've only been taking this medication for a short while, but I already feel so much better. My fatigue is gone and my memory is improved. This has truly been a blessing.
5Patient Review
2/22/2021 This medication, in combination with a gluten and sugar-free diet, has helped me immensely. I've started to see hair growth and a reduction in pain and fatigue.
5Patient Review
3/9/2021 I've been taking levothyroxine for a while now and it's worked great for me. I highly recommend it to others.
5Patient Review
5/17/2022 I have a long history of medication side effects, some of which were very serious. So, I generally resist taking medication unless it is absolutely necessary. I am grateful that I started Levothyroxine in January with no side effects. My TSH is now within the normal range--this change has made a big difference for me.
5Patient Review
2/22/2021 This medication, in combination with a gluten and sugar-free diet, has done wonders for my Hashimoto's. I highly recommend it to others struggling with similar thyroid issues.
5Patient Review
5/17/2022 I have a long history of medication side effects, some of which were very serious. So, I generally resist medications until they are absolutely necessary. I am grateful to have started Levothyroxine in January with no side effects. My TSH is now within the normal range--a huge relief.
5Patient Review
9/7/2022 I was diagnosed with low thyroid in December 2021. I was put on levoxine tablets 75mg and they worked great for me. My thyroid levels have significantly improved since then.
5Patient Review
9/7/2022 I was diagnosed with low thyroid in December 2021 and put on levoxine tablets. They worked great for me and my thyroid levels have significantly improved.
5Patient Review
5/11/2020 I've only been taking this for about two weeks, but I'm already feeling much better. My fatigue is gone, my memory has improved, and I feel mentally sharper overall. This has been a huge blessing.
5Patient Review
3/9/2021 I've been taking levothyroxine for a while now and it's really effective. I would definitely recommend it to others.
4Patient Review
4/19/2020 I started taking this medication when I turned 60 and it's been effective; however, I have noticed an uptick in my weight.
4Patient Review
4/19/2020 I started taking this medication when I turned 60 and it's been effective. However, I have noticed that I've gained weight since then.
4Patient Review
10/26/2021 This medication has been working great for me. It's keeping my thyroid under control with no issues.
4Patient Review
10/26/2021 This medication has been great for keeping my thyroid in check.
4Patient Review
10/26/2021 So far, I've had a great experience with this medication. It's keeping my thyroid in check without any negative side effects that I can tell.
4Patient Review
4/19/2020 I started taking this medication when I turned 60 and it's been effective, though I have put on some extra weight.
2Patient Review
8/30/2021 My doctor put me on this medication, and my thyroid results were already in the high range. He would increase and decrease my dosage, but now I have all sorts of problems like brain fog.
2Patient Review
8/30/2021 I was prescribed this medication by my doctor, but it seems to have made my thyroid problems worse. I've also been experiencing brain fog and a whole host of other issues since starting it. I don't know what to do at this point.
2Patient Review
8/30/2021 I was already having some problems with my thyroid before starting this medication, and since then it's been a rollercoaster. I've experienced brain fog, fatigue, and a host of other issues. I don't know what to do at this point.
1.7Patient Review
9/29/2020 I was on Synthroid and doing just fine, but my NP switched me to Levothyroxine without my permission. They based this decision entirely off of TSH test results, which are notoriously inaccurate. I've been taking the 88mcg dose for over a month now and have only seen negative changes: weight gain, water retention, fatigue, etc.
1.7Patient Review
7/27/2020 I started experiencing dry throat and mouth, acne, headaches, and low back pain shortly after beginning this medication.
1.7Patient Review
9/29/2020 I was on Synthroid, which worked great for me. However, my NP switched me to Levothyroxine without my permission and is basing the decision only on TSH test results, which are entirely inaccurate. I've been taking Levothyroxine for over a month now, and I have gained weight, retained water, and feel fatigued.
1.7Patient Review
9/29/2020 I was prescribed Levothyroxine 88mcg without my consent, and I have been feeling terrible since I started taking it. I've gained weight, can't seem to get rid of water retention, and am always exhausted.
1.7Patient Review
7/27/2020 I've developed a really dry throat and mouth, acne, headaches, and low back pain since starting this medication.
1.7Patient Review
7/27/2020 I immediately started experiencing a whole host of negative side effects when I began taking this medication, including a dry throat and mouth, acne, headaches, and low back pain.
1.3Patient Review
12/17/2021 I was diagnosed with high TSH levels after a routine blood test in the hospital. I experienced no symptoms prior to this. I've been on various doses of medication for the past three years, but have only seen negative side effects since then. These include anxiety, depression, and shallow sleep. I'm ready to stop taking the medication and hopefully get back to normal.
1.3Patient Review
12/17/2021 I was diagnosed with high TSH levels in the hospital during a routine blood test. I had no symptoms at the time. Three years later, and after trying different doses of medication, I have only experienced negative side effects like anxiety, depression, and shallow sleep. I'm ready to stop taking this medication for good and hopefully get back to normal.
1.3Patient Review
12/17/2021 I was diagnosed with high TSH levels after a routine blood test in the hospital. I had no symptoms at the time. Three years later, and after trying different doses of medication, I have only experienced negative side effects like anxiety, depression, and shallow sleep. I'm ready to stop taking this medication for good and hopefully get back to normal.
1Patient Review
11/15/2021 These leg cramps were unbearable.
1Patient Review
11/15/2021 I was dealing with some really bad leg cramps.
1Patient Review
11/15/2021 These leg cramps were unbearable.
Patient Q&A Section about levo-t
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Levo-T the same as SYNTHROID?
"Levoxyl and Synthroid are Levothyroxine drug brands that have the same active ingredient but different inactive ingredients."
Answered by AI
What is Levo-T used for?
"Levothyroxine treats an underactive thyroid by providing more thyroid hormone. Low thyroid hormone levels can be caused by a natural deficiency, or by damage to the thyroid gland from radiation or surgery."
Answered by AI
What does Levo mean in levothyroxine?
"It seems that the prefix "levo-" might mean "on the left side", as in levorotation (turning or twisting to the left). This is helpful to know."
Answered by AI