Levo-T

Hypothyroidism, Comatose, euthyroid Goitre + 3 more
Treatment
5 FDA approvals
10 Active Studies for Levo-T

What is Levo-T

LevothyroxineThe Generic name of this drug
Treatment SummaryLevothyroxine is a synthetic hormone used to treat hypothyroidism, a condition where the thyroid gland does not make enough of the hormones T4 and T3. Symptoms of hypothyroidism include fatigue, increased heart rate, depression, dry skin and hair, muscle cramps, constipation, weight gain, memory impairment, and poor tolerance to cold temperatures. Levothyroxine replaces the hormones that the thyroid is lacking and helps the body to function normally. It is more commonly known by its brand name Synthroid. Prior to the development of levothyroxine, the main treatment for hypothyroidism was des
Thyrolaris the brand name
image of different drug pills on a surface
Levo-T Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Thyrolar
Levothyroxine
1969
1177

Approved as Treatment by the FDA

Levothyroxine, also known as Thyrolar, is approved by the FDA for 5 uses including Hypothyroidism and thyrotropin dependent Thyroid cancer .
Hypothyroidism
Helps manage Hypothyroidism
thyrotropin dependent Thyroid cancer
Hypothyroidism
Helps manage Hypothyroidism
Malignant Neoplasms
euthyroid Goitre
Helps manage euthyroid Goitre

Effectiveness

How Levo-T Affects PatientsLevothyroxine is a synthetic hormone that helps keep a normal level of thyroid hormones in the body when there is a deficiency. Too much or too little of this hormone can lead to a variety of negative effects, such as changes in growth and development, cardiovascular problems, and problems with metabolism. It is important to carefully adjust the dose of levothyroxine and monitor the patient's response to avoid over-treatment. If the thyroid hormone level is too high, it can cause an increase in heart rate, tremor, and weakness. People with any kind of heart issues should take a lower dose of levothyroxine. Too much
How Levo-T works in the bodyLevothyroxine is a manmade version of thyroxine, a hormone produced by the thyroid gland. It helps to regulate metabolism, brain function and body temperature. In people with hypothyroidism, taking levothyroxine can help to relieve symptoms like slow speech, fatigue, weight gain and hair loss. Thyroid hormones work by both entering the cell nucleus and binding to genes, as well as binding to proteins on the cell surface. These actions help to regulate heart rate, cardiac output, systemic vascular resistance and other important functions. They also control angiogenesis and tumor cell proliferation.

When to interrupt dosage

The amount of Levo-T is contingent upon the diagnosed situation, such as Comatose, Edematous Fibrosclerotic Panniculopathy (Cellulite) and Adiposity. Dosage likewise varies as per the method of delivery delineated in the table below.
Condition
Dosage
Administration
Hypothyroidism
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Topical, Tablet - Topical, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Cellulite
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Topical, Tablet - Topical, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Adiposity
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Topical, Tablet - Topical, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
euthyroid Goitre
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Topical, Tablet - Topical, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Malignant Neoplasms
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Topical, Tablet - Topical, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous
Comatose
, 0.025 mg, 0.05 mg, 0.075 mg, 0.088 mg, 0.1 mg, 0.112 mg, 0.125 mg, 0.15 mg, 0.175 mg, 0.2 mg, 0.3 mg, 0.137 mg, 0.038 mg, 0.019 mg, 0.057 mg, 0.038 mCi, 0.5 mg, 0.2 mg/mL, 0.5 mg/mL, 0.1 mg/mL, 0.0095 mg, 0.013 mg, 0.076 mg, 0.0125 mg, 0.114 mg, 0.15 mg/mL, 0.137 mg/mL, 0.175 mg/mL, 0.112 mg/mL, 0.125 mg/mL, 0.088 mg/mL, 0.075 mg/mL, 0.05 mg/mL, 0.025 mg/mL, 0.013 mg/mL, 0.04 mg/mL, 0.02 mg/mL, 0.0375 mg/mL, 0.0625 mg/mL, 0.044 mg/mL
, Oral, Tablet, Tablet - Oral, Intravenous, Liquid, Liquid - Intravenous, Intramuscular; Intravenous, Powder, for solution, Powder, for solution - Intramuscular; Intravenous, Injection, powder, lyophilized, for solution, Injection, powder, lyophilized, for solution - Intravenous, Capsule - Oral, Capsule, Topical, Tablet - Topical, Solution - Oral, Solution, Injection - Intravenous, Injection, Injection, solution, Injection, solution - Intravenous, Solution - Intramuscular; Intravenous

Warnings

Levo-T has four contraindications, so it should be avoided if any of the conditions listed in the following table are present.Levo-T Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Heart Attack
Do Not Combine
Thyrotoxicosis
Do Not Combine
Adrenal gland hypofunction
Do Not Combine
There are 20 known major drug interactions with Levo-T.
Common Levo-T Drug Interactions
Drug Name
Risk Level
Description
Abemaciclib
Major
The serum concentration of Abemaciclib can be decreased when it is combined with Levothyroxine.
Bendamustine
Major
The serum concentration of Bendamustine can be decreased when it is combined with Levothyroxine.
Berotralstat
Major
The serum concentration of Berotralstat can be decreased when it is combined with Levothyroxine.
Binimetinib
Major
The serum concentration of Binimetinib can be decreased when it is combined with Levothyroxine.
Bortezomib
Major
The serum concentration of Bortezomib can be decreased when it is combined with Levothyroxine.
Levo-T Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats is 20 mg/kg when administered orally. This can cause a range of symptoms similar to those seen in thyroid problems, such as weight loss, increased appetite, palpitations, nervousness, diarrhea, abdominal cramps, sweating, rapid heart rate, increased pulse and blood pressure, irregular heartbeat, shaking, insomnia, difficulty tolerating heat or fever, and menstrual changes.
image of a doctor in a lab doing drug, clinical research

Levo-T Novel Uses: Which Conditions Have a Clinical Trial Featuring Levo-T?

15 active studies are presently examining the potential of Levo-T in treating Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism and Comatose States.
Condition
Clinical Trials
Trial Phases
euthyroid Goitre
0 Actively Recruiting
Hypothyroidism
5 Actively Recruiting
Phase 4, Phase 2, Phase 3, Not Applicable
Comatose
0 Actively Recruiting
Malignant Neoplasms
0 Actively Recruiting
Cellulite
0 Actively Recruiting
Adiposity
5 Actively Recruiting
Not Applicable, Phase 4

Levo-T Reviews: What are patients saying about Levo-T?

5Patient Review
2/22/2021
Levo-T for A Progressive Disease of the Thyroid Gland
This medication, in combination with a gluten and sugar-free diet, has helped me immensely.
5Patient Review
5/11/2020
Levo-T for Underactive Thyroid
I've only been taking this for a short while, but I'm already feeling much better. My fatigue is gone and my mental clarity has returned. This has really been a blessing.
5Patient Review
5/17/2022
Levo-T for A Progressive Disease of the Thyroid Gland
I have a long history of medication side effects. Some of them were very serious. So I resist medications until they are absolutely necessary. I am grateful to have started Levothyroxine in January with no side effects. My TSH is now within normal range. Very grateful.
5Patient Review
3/9/2021
Levo-T for Underactive Thyroid
I've been taking levothyroxine for a while now and it's been working great. I would definitely recommend it to others.
5Patient Review
9/7/2022
Levo-T for Underactive Thyroid
I was diagnosed with low thyroid in December 2021. They put me on Levoxine tablets, and my thyroid levels have significantly improved since then. I'm feeling much better overall thanks to this treatment!
5Patient Review
5/11/2020
Levo-T for Underactive Thyroid
I've only been taking this medication for a short while, but I already feel so much better. My fatigue is gone and my memory is improved. This has truly been a blessing.
5Patient Review
2/22/2021
Levo-T for A Progressive Disease of the Thyroid Gland
This medication, in combination with a gluten and sugar-free diet, has helped me immensely. I've started to see hair growth and a reduction in pain and fatigue.
5Patient Review
3/9/2021
Levo-T for Underactive Thyroid
I've been taking levothyroxine for a while now and it's worked great for me. I highly recommend it to others.
5Patient Review
5/17/2022
Levo-T for A Progressive Disease of the Thyroid Gland
I have a long history of medication side effects, some of which were very serious. So, I generally resist taking medication unless it is absolutely necessary. I am grateful that I started Levothyroxine in January with no side effects. My TSH is now within the normal range--this change has made a big difference for me.
5Patient Review
2/22/2021
Levo-T for A Progressive Disease of the Thyroid Gland
This medication, in combination with a gluten and sugar-free diet, has done wonders for my Hashimoto's. I highly recommend it to others struggling with similar thyroid issues.
5Patient Review
5/17/2022
Levo-T for A Progressive Disease of the Thyroid Gland
I have a long history of medication side effects, some of which were very serious. So, I generally resist medications until they are absolutely necessary. I am grateful to have started Levothyroxine in January with no side effects. My TSH is now within the normal range--a huge relief.
5Patient Review
9/7/2022
Levo-T for Underactive Thyroid
I was diagnosed with low thyroid in December 2021. I was put on levoxine tablets 75mg and they worked great for me. My thyroid levels have significantly improved since then.
5Patient Review
9/7/2022
Levo-T for Underactive Thyroid
I was diagnosed with low thyroid in December 2021 and put on levoxine tablets. They worked great for me and my thyroid levels have significantly improved.
5Patient Review
5/11/2020
Levo-T for Underactive Thyroid
I've only been taking this for about two weeks, but I'm already feeling much better. My fatigue is gone, my memory has improved, and I feel mentally sharper overall. This has been a huge blessing.
5Patient Review
3/9/2021
Levo-T for Underactive Thyroid
I've been taking levothyroxine for a while now and it's really effective. I would definitely recommend it to others.
4Patient Review
4/19/2020
Levo-T for Underactive Thyroid
I started taking this medication when I turned 60 and it's been effective; however, I have noticed an uptick in my weight.
4Patient Review
4/19/2020
Levo-T for Underactive Thyroid
I started taking this medication when I turned 60 and it's been effective. However, I have noticed that I've gained weight since then.
4Patient Review
10/26/2021
Levo-T for Underactive Thyroid
This medication has been working great for me. It's keeping my thyroid under control with no issues.
4Patient Review
10/26/2021
Levo-T for Underactive Thyroid
This medication has been great for keeping my thyroid in check.
4Patient Review
10/26/2021
Levo-T for Underactive Thyroid
So far, I've had a great experience with this medication. It's keeping my thyroid in check without any negative side effects that I can tell.
4Patient Review
4/19/2020
Levo-T for Underactive Thyroid
I started taking this medication when I turned 60 and it's been effective, though I have put on some extra weight.
2Patient Review
8/30/2021
Levo-T for A Progressive Disease of the Thyroid Gland
My doctor put me on this medication, and my thyroid results were already in the high range. He would increase and decrease my dosage, but now I have all sorts of problems like brain fog.
2Patient Review
8/30/2021
Levo-T for A Progressive Disease of the Thyroid Gland
I was prescribed this medication by my doctor, but it seems to have made my thyroid problems worse. I've also been experiencing brain fog and a whole host of other issues since starting it. I don't know what to do at this point.
2Patient Review
8/30/2021
Levo-T for A Progressive Disease of the Thyroid Gland
I was already having some problems with my thyroid before starting this medication, and since then it's been a rollercoaster. I've experienced brain fog, fatigue, and a host of other issues. I don't know what to do at this point.
1.7Patient Review
9/29/2020
Levo-T for Underactive Thyroid
I was on Synthroid and doing just fine, but my NP switched me to Levothyroxine without my permission. They based this decision entirely off of TSH test results, which are notoriously inaccurate. I've been taking the 88mcg dose for over a month now and have only seen negative changes: weight gain, water retention, fatigue, etc.
1.7Patient Review
7/27/2020
Levo-T for Underactive Thyroid
I started experiencing dry throat and mouth, acne, headaches, and low back pain shortly after beginning this medication.
1.7Patient Review
9/29/2020
Levo-T for Underactive Thyroid
I was on Synthroid, which worked great for me. However, my NP switched me to Levothyroxine without my permission and is basing the decision only on TSH test results, which are entirely inaccurate. I've been taking Levothyroxine for over a month now, and I have gained weight, retained water, and feel fatigued.
1.7Patient Review
9/29/2020
Levo-T for Underactive Thyroid
I was prescribed Levothyroxine 88mcg without my consent, and I have been feeling terrible since I started taking it. I've gained weight, can't seem to get rid of water retention, and am always exhausted.
1.7Patient Review
7/27/2020
Levo-T for Underactive Thyroid
I've developed a really dry throat and mouth, acne, headaches, and low back pain since starting this medication.
1.7Patient Review
7/27/2020
Levo-T for Underactive Thyroid
I immediately started experiencing a whole host of negative side effects when I began taking this medication, including a dry throat and mouth, acne, headaches, and low back pain.
1.3Patient Review
12/17/2021
Levo-T for A Progressive Disease of the Thyroid Gland
I was diagnosed with high TSH levels after a routine blood test in the hospital. I experienced no symptoms prior to this. I've been on various doses of medication for the past three years, but have only seen negative side effects since then. These include anxiety, depression, and shallow sleep. I'm ready to stop taking the medication and hopefully get back to normal.
1.3Patient Review
12/17/2021
Levo-T for A Progressive Disease of the Thyroid Gland
I was diagnosed with high TSH levels in the hospital during a routine blood test. I had no symptoms at the time. Three years later, and after trying different doses of medication, I have only experienced negative side effects like anxiety, depression, and shallow sleep. I'm ready to stop taking this medication for good and hopefully get back to normal.
1.3Patient Review
12/17/2021
Levo-T for A Progressive Disease of the Thyroid Gland
I was diagnosed with high TSH levels after a routine blood test in the hospital. I had no symptoms at the time. Three years later, and after trying different doses of medication, I have only experienced negative side effects like anxiety, depression, and shallow sleep. I'm ready to stop taking this medication for good and hopefully get back to normal.
1Patient Review
11/15/2021
Levo-T for Underactive Thyroid
These leg cramps were unbearable.
1Patient Review
11/15/2021
Levo-T for Underactive Thyroid
I was dealing with some really bad leg cramps.
1Patient Review
11/15/2021
Levo-T for Underactive Thyroid
These leg cramps were unbearable.

Patient Q&A Section about levo-t

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Levo-T the same as levothyroxine?

"This medication is used to treat low thyroid hormone levels. It is also used to prevent or treat goiter (enlarged thyroid gland), which can be caused by hormone imbalances, radiation treatment, surgery, or cancer."

Answered by AI

Is Levo-T the same as SYNTHROID?

"Levoxyl and Synthroid are Levothyroxine drug brands that have the same active ingredient but different inactive ingredients."

Answered by AI

What is Levo-T used for?

"Levothyroxine treats an underactive thyroid by providing more thyroid hormone. Low thyroid hormone levels can be caused by a natural deficiency, or by damage to the thyroid gland from radiation or surgery."

Answered by AI

What does Levo mean in levothyroxine?

"It seems that the prefix "levo-" might mean "on the left side", as in levorotation (turning or twisting to the left). This is helpful to know."

Answered by AI

Clinical Trials for Levo-T

Image of Cleveland Clinic in Cleveland, United States.

Gluten Free Diet for Hashimoto's Disease

Any Age
All Sexes
Cleveland, OH
Hashimoto's thyroiditis is an autoimmune condition that reduces functioning of the thyroid gland and can lead to a substantial decline in quality of life for patients, with impacted patients often describing unremitting brain fog, fatigue/malaise and weight gain leading to difficulty functioning in their jobs and homes. It is the most common cause of hypothyroidism in the U.S. and affects up to 10% of the global population. The typical treatment for Hashimoto's is thyroid hormone replacement with medications such as levothyroxine. However, despite adequate treatment as defined by thyroid hormone levels within the reference range, up to 10% of patients will experience persisting symptoms which can dramatically impair quality of life. While various theories have been postulated for the residual symptoms, several studies indicate that they are related to the thyroid autoimmunity, specifically the autoantibodies that are made by the immune system in Hashimoto's thyroiditis in response to the thyroid (ie thyroid peroxidase \[TPO\], thyroglobulin \[Tg\] antibody \[AB\]) and the associated inflammation with the immune response. Removal of thyroid (ie total thyroidectomy) reduces levels of these thyroid antibodies and results in significant improvement in quality-of-life. However, thyroidectomy is an invasive procedure with potential for morbidity such as damage to the recurrent laryngeal (nerve that controls the vocal cords and thus speech), bleeding and infection, so there is interest in other more conservative modalities for lowering the inflammation and autoimmune burden in Hashimoto's thyroiditis. In an effort to identify a less invasive approach for reducing the levels of thyroid antibodies and inflammation, attention has moved to the intersection of Hashimoto's thyroiditis and the gut. Hashimoto's has a strong association with autoimmune disorders impacting the gastrointestinal tract, in particular celiac disease and non-celiac gluten sensitivity (NCGS). NCGS is a condition where there are intestinal and extra-intestinal symptoms associated the consumption of gluten but no presence of anti-tissue transglutaminase antibodies (anti-tTG) which define Celiac Disease. This connection between Hashimoto's thyroiditis and sensitivity to gluten appears to be not only genetic, as those with Celiac Disease/NCGS and Hashimoto's thyroiditis have common HLA haplotypes, but also at the level of the intestine with gut microbiome dysfunction.
Recruiting
Has No Placebo
Cleveland Clinic
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Novel Treatments for Hypothyroidism

18+
All Sexes
Farmington, CT
Hypothyroidism is a common condition, more frequent in females, associated with excess of cardiovascular risk and poor quality of life not completely abrogated by treatment with levothyroxine. There is an unmet need to define a safe, effective, and feasible regimen to be applied in large trials aimed at assessing levothyroxine/liothyronine combination therapy in patients living with hypothyroidism. To address this knowledge gap we propose a randomized, three-arm, double-blind, controlled, escalating dose parallel pilot study whose results will lay the foundation of large multicenter trial(s) able to demonstrate the effectiveness (or lack thereof) of levothyroxine/liothyronine combination therapy.
Phase 2 & 3
Recruiting
UConn HealthFrancesco Celi
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Image of University of Colorado Anschutz Medical Campus in Aurora, United States.

Estradiol Patch for Menopause

20 - 45
Female
Aurora, CO
The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease. The purpose of this research is to study how the decrease in estrogen at menopause changes artery health and fat gain, and risk of disease in women as they age. The first aim in this study will determine whether short term and long term low estrogen levels in premenopausal women decreases artery function and whether this is related to an increase in fat in the stomach area. The second aim will determine whether the changes in artery health and body fat are related to changes in a pathway that breaks down an important amino acid called tryptophan. This pathway is thought to play a role in regulating the aging process. Therefore, the investigators will determine whether the decrease in artery health and the increase in body fat in the stomach region with low estrogen is related to changes in this pathway in the blood, in vascular cells and fat tissue. Because estrogen levels fluctuate in premenopausal women, the investigators will use an approach (intervention) that controls estrogen levels to address these aims. The investigators will use a medication that is typically used to treat endometriosis or uterine fibroids to lower estrogen levels and an estrogen patch to increase estrogen in some women. Some women will receive a patch that has no estrogen (called a placebo patch). The intervention period will be 20 weeks. The study will provide us with new knowledge on how low estrogen with menopause affects artery health and fat gain estrogen.
Phase 4
Recruiting
University of Colorado Anschutz Medical CampusKerrie Moreau, PhD
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Weight Loss for Obesity

18 - 70
All Sexes
Aurora, CO
The goal of this intervention study is to learn about how weight loss impacts molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. The main question it aims to answer is how inflammatory molecules secreted by IMAT promote muscle insulin resistance and inflammation, and how these same molecules are diminished after weight loss. Following screening visits involving body composition measures, blood testing, strength testing, and a thigh muscle biopsy, participants will go through a 12-week dietary intervention for weight loss. After 12 weeks, this will be followed by the same testing and biopsies that were completed before the intervention. Researchers will then compare outcomes of individuals who lost weight to individuals who did not lose weight.
Recruiting
Has No Placebo
University of Colorado Anschutz
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