Lamictal Odt

Bipolar Disorder, Seizures, Seizures + 3 more
Treatment
4 FDA approvals
7 Active Studies for Lamictal Odt

What is Lamictal Odt

LamotrigineThe Generic name of this drug
Treatment SummaryLamotrigine is a medication used to treat seizures and bipolar disorder. It is the first drug approved by the FDA for maintenance treatment of bipolar I since lithium. Lamotrigine is well-tolerated and does not require regular lab tests. It may also be helpful in treating certain types of nerve pain.
Lamictalis the brand name
image of different drug pills on a surface
Lamictal Odt Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lamictal
Lamotrigine
1995
543

Approved as Treatment by the FDA

Lamotrigine, also known as Lamictal, is approved by the FDA for 4 uses such as Partial-Onset Seizures and Seizures .
Partial-Onset Seizures
Seizures
Currently on standardized therapy
Conversion to monotherapy

Effectiveness

How Lamictal Odt Affects PatientsLamotrigine helps to control seizures and improve mood by keeping nerve cells in the brain stable and preventing the release of excitatory chemicals, like glutamate, which can cause seizures. It has been noted to have an effect on the cardiovascular system, with a metabolite (substance created during metabolism) of lamotrigine being linked to changes in heart rate and rhythm. This metabolite is usually found in small amounts in people, but may increase if there is a decrease in the amount of drug that is metabolized due to liver disease.
How Lamictal Odt works in the bodyLamotrigine works by blocking sodium channels in the brain, which helps to stabilize nerve cell activity. It also binds to several different receptors in the body, which can help to reduce nerve pain, seizures and other symptoms related to bipolar disorder. Lamotrigine also weakly binds to Adenosine A1/A2 receptors, adrenergic receptors, dopamine receptors, GABA receptors, histamine receptors, opioid receptors and serotonin receptors. It has also been shown to inhibit certain calcium currents, which may also contribute to its anticonvulsant effects.

When to interrupt dosage

The recommended measure of Lamictal Odt is contingent upon the determined condition, such as Bipolar Disorder, Seizures and Lennox Gastaut Syndrome (LGS). The amount of dosage fluctuates as per the technique of delivery featured in the table beneath.
Condition
Dosage
Administration
Conversion to monotherapy
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Lennox Gastaut Syndrome
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Seizures
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Bipolar Disorder
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Seizures
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral
Currently on standardized therapy
, 25.0 mg, 5.0 mg, 200.0 mg, 150.0 mg, 100.0 mg, 300.0 mg, 50.0 mg, 250.0 mg, 2.0 mg, 75.0 mg, 350.0 mg, 175.0 mg, 125.0 mg
, Oral, Tablet, chewable - Oral, Tablet, chewable, Tablet, Tablet - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Kit, Tablet, extended release, Tablet, extended release - Oral, Tablet, for suspension, Tablet, for suspension - Oral, Kit - Oral

Warnings

Lamictal Odt has one contraindication, and it should not be taken when afflicting with the conditions in the subsequent table.Lamictal Odt Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Lamotrigine may interact with Pulse Frequency
There are 20 known major drug interactions with Lamictal Odt.
Common Lamictal Odt Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Lamotrigine is combined with Aclidinium.
Axitinib
Major
The metabolism of Axitinib can be increased when combined with Lamotrigine.
Azelastine
Major
Lamotrigine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Belinostat
Major
The metabolism of Belinostat can be increased when combined with Lamotrigine.
Binimetinib
Major
The metabolism of Binimetinib can be increased when combined with Lamotrigine.
Lamictal Odt Toxicity & Overdose RiskThe lowest toxic dose of lamotrigine in mice and rats is 205mg/kg and 245mg/kg, respectively. Severe cases of overdose have seen up to 15g of lamotrigine ingested. Symptoms of overdose include coordination problems, eye twitching, increased seizures, decreased level of consciousness, coma, and changes to the heartbeat. There is no known antidote for lamotrigine, but supportive treatments such as hospitalization, airway protection, and stomach pumping may be recommended. It is not clear whether hemodialysis can remove the drug from the body.

Lamictal Odt Novel Uses: Which Conditions Have a Clinical Trial Featuring Lamictal Odt?

A total of 8 active trials are being conducted to investigate the potential of Lamictal Odt in alleviating Seizures, Seizures and Lennox Gastaut Syndrome (LGS).
Condition
Clinical Trials
Trial Phases
Bipolar Disorder
0 Actively Recruiting
Seizures
0 Actively Recruiting
Lennox Gastaut Syndrome
3 Actively Recruiting
Phase 2, Phase 1, Phase 4
Seizures
4 Actively Recruiting
Phase 3, Phase 2
Conversion to monotherapy
0 Actively Recruiting
Currently on standardized therapy
0 Actively Recruiting

Lamictal Odt Reviews: What are patients saying about Lamictal Odt?

5Patient Review
4/9/2012
Lamictal Odt for Rapid Cycle Manic-Depression
Lamictal has been the most effective antidepressant I've ever taken, and I'm incredibly grateful for it.
5Patient Review
5/1/2013
Lamictal Odt for Simple Partial Seizures
Lamictal has been a game-changer for me in terms of managing my bipolar disorder. It's helped to lengthen the time between my mood swings and I've been taking it consistently for almost 8 months now. I would highly recommend it to anyone suffering from bipolar disorder.
5Patient Review
8/29/2013
Lamictal Odt for Bipolar Depression
I was having partial seizures and this medication has been incredibly effective. The only downside is that I've experienced sleep deprivation and weight gain.
4.3Patient Review
1/23/2011
Lamictal Odt for Rapid Cycle Manic-Depression
4.3Patient Review
4/24/2011
Lamictal Odt for Bipolar Depression
View All Reviews
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Patient Q&A Section about lamictal odt

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is Lamictal ODT used for?

"This drug is commonly used to either prevent or control seizures in patients with epilepsy. It is also used to help stabilize the drastic mood swings associated with bipolar disorder in adults. However, this drug is not recommended for use in children aged two years or younger due to the increased risk of developing side effects, such as infections."

Answered by AI

What is lamotrigine orally disintegrating?

"This medicine is Lamotrigine, and it is used to control seizures in adults and children with epilepsy and Lennox-Gastaut syndrome. It is also used in adults to treat bipolar disorder. The Lamictal ODT is an oral disintegrating tablet."

Answered by AI

Can I swallow Lamictal ODT?

"The tablet will dissolve quickly when exposed to saliva and can be swallowed. It is not necessary to take the tablet with food or water. Do not use the medication if the blister packaging is torn, broken, or missing."

Answered by AI

Is lamotrigine ODT extended-release?

"Lamictal comes in four brands: Lamictal, Lamictal XR, Lamictal CD, and Lamictal ODT. The four Lamictal brands are immediate-release oral tablets, extended-release oral tablets, chewable oral tablets, and orally disintegrating tablets (can be dissolved on the tongue)."

Answered by AI

Clinical Trials for Lamictal Odt

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