Study Summary
This trial will test whether CBD can help reduce inflammation in the brain and help lessen pain sensitization.
Eligible Conditions
- Cannabidiol
- Healthy Subjects
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 1 Secondary · Reporting Duration: 10 Days
10 Days
Capsaicin-induced hyperalgesia
Microglial activation using [11C]PBR28 PET imaging
Trial Safety
Safety Progress
Trial Design
2 Treatment Groups
CBD
1 of 2
Placebo
1 of 2
Active Control
Non-Treatment Group
15 Total Participants · 2 Treatment Groups
Primary Treatment: CBD · Has Placebo Group · Phase < 1
CBDActiveComparator Group · 3 Interventions: Intradermal Capsaicin, [11C]PBR28, Low-dose lipopolysaccharide · Intervention Types: Drug, Radiation, Drug
PlaceboPlaceboComparator Group · 3 Interventions: Intradermal Capsaicin, [11C]PBR28, Low-dose lipopolysaccharide · Intervention Types: Drug, Radiation, Drug
Trial Logistics
Trial Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 10 days
Who is running the clinical trial?
National Center for Complementary and Integrative Health (NCCIH)NIH
781 Previous Clinical Trials
657,072 Total Patients Enrolled
Yale UniversityLead Sponsor
1,680 Previous Clinical Trials
21,088,244 Total Patients Enrolled
Rajiv Radhakrishnan, MDPrincipal Investigator - Yale University
Yale University
1 Previous Clinical Trials
18 Total Patients Enrolled
Eligibility Criteria
Age 18 - 55 · All Participants · 5 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Who else is applying?
What state do they live in?
| Connecticut | 66.7% |
| California | 33.3% |
How old are they?
| 18 - 65 | 100.0% |
What site did they apply to?
| Connecticut Mental Health Center | 100.0% |
What portion of applicants met pre-screening criteria?
| Met criteria | 66.7% |
| Did not meet criteria | 33.3% |
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Conditions
Cancer Related
Treatments