Locoid Lipocream

Pruritus, Pruritus, corticosteroid responsive, Inflammatory Dermatosis

Treatment

4 FDA approvals

0 Active Studies for Locoid Lipocream

Treatment for

Pruritus

What is Locoid Lipocream

Hydrocortisone butyrate

The Generic name of this drug

Hydrocortisone Butyrate

is the brand name

image of different drug pills on a surface

Locoid Lipocream Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Hydrocortisone Butyrate

Hydrocortisone butyrate

1987

Approved as Treatment by the FDA

Hydrocortisone butyrate, also known as Hydrocortisone Butyrate, is approved by the FDA for 4 uses like Atopic Dermatitis and Pruritus .

Atopic Dermatitis

Pruritus

corticosteroid responsive, Inflammatory Dermatosis

Pruritus

Effectiveness

How Locoid Lipocream Affects Patients

Hydrocortisone is a steroid hormone necessary for life. It regulates many body functions, such as blood pressure, metabolism, immune system, and homeostasis. Hydrocortisone is used to treat inflammation caused by skin conditions. It reduces inflammation by stopping the body from producing certain proteins (cytokines) that cause inflammation. These proteins are called IL-1, IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and TNF-alpha. Hydrocortisone also reduces the production of another protein (IL-2) that is involved

How Locoid Lipocream works in the body

Hydrocortisone works to reduce inflammation by stopping the production of molecules that cause inflammation. It does this by binding to a receptor in cells, then travelling to the cell nucleus and activating genes that suppress inflammation. It also prevents an enzyme from coming into contact with a molecule that helps create inflammation-causing molecules. This stops the production of these molecules, which reduces inflammation. Additionally, hydrocortisone suppresses the immune system by decreasing the amount of antibodies and disrupting the binding of antigens to antibodies. It also reduces the function of the lymphatic system, which is a key part of the immune response.

When to interrupt dosage

The dosage of Locoid Lipocream is contingent upon the identified condition, including Atopic Dermatitis, Pruritus and corticosteroid responsive, Inflammatory Dermatosis. The degree of dosage is delineated in the table below, dependent upon the technique of delivery (e.g. Cream or Patch - Cutaneous).

Condition

Dosage

Administration

Pruritus

, 0.001 mg/mg, 1.0 mg/mL, 0.0016 mg/hour, 0.00003 mg/mg, 0.003 mg/mg

Topical, Cream - Topical, Cream, Ointment, , Ointment - Topical, Solution, Lotion, Lotion - Topical, Cutaneous, Patch - Cutaneous, Patch, Solution - Topical

Pruritus

, 0.001 mg/mg, 1.0 mg/mL, 0.0016 mg/hour, 0.00003 mg/mg, 0.003 mg/mg

Topical, Cream - Topical, Cream, Ointment, , Ointment - Topical, Solution, Lotion, Lotion - Topical, Cutaneous, Patch - Cutaneous, Patch, Solution - Topical

corticosteroid responsive, Inflammatory Dermatosis

, 0.001 mg/mg, 1.0 mg/mL, 0.0016 mg/hour, 0.00003 mg/mg, 0.003 mg/mg

Topical, Cream - Topical, Cream, Ointment, , Ointment - Topical, Solution, Lotion, Lotion - Topical, Cutaneous, Patch - Cutaneous, Patch, Solution - Topical

Warnings

There are 20 known major drug interactions with Locoid Lipocream.

Common Locoid Lipocream Drug Interactions

Drug Name

Risk Level

Description

Abemaciclib

Major

The metabolism of Abemaciclib can be increased when combined with Hydrocortisone butyrate.

Acalabrutinib

Major

The metabolism of Acalabrutinib can be increased when combined with Hydrocortisone butyrate.

Alectinib

Major

The metabolism of Alectinib can be increased when combined with Hydrocortisone butyrate.

Alpelisib

Major

The metabolism of Alpelisib can be increased when combined with Hydrocortisone butyrate.

Aminophylline

Major

The metabolism of Aminophylline can be increased when combined with Hydrocortisone butyrate.

Locoid Lipocream Toxicity & Overdose Risk

The side effects of taking this drug include reduced bone formation, decreased calcium absorption, and slower healing of wounds.

image of a doctor in a lab doing drug, clinical research

Locoid Lipocream Novel Uses: Which Conditions Have a Clinical Trial Featuring Locoid Lipocream?

67 active studies are assessing the potential of Locoid Lipocream to relieve Atopic Dermatitis, Pruritus and corticosteroid responsive Inflammatory Dermatoses.

Condition

Clinical Trials

Trial Phases

Pruritus

0 Actively Recruiting

corticosteroid responsive, Inflammatory Dermatosis

0 Actively Recruiting

Pruritus

0 Actively Recruiting

Locoid Lipocream Reviews: What are patients saying about Locoid Lipocream?

Patient Review

3/22/2012

Locoid Lipocream for Skin Condition

I had to use this for my severe eczema. Locoid was the only cream that worked immediately and with little effort. I only needed to use a very small amount, once a day (or at most, twice a day). It lasted me over a year on one tube! The only downside is that after prolonged use, my skin got used to it and it stopped being as effective.

Patient Review

8/15/2012

Locoid Lipocream for Inflammation of Skin caused by an Allergy

My doctor perscribed this medication, but I didn't find that it worked any better than the hydrocortizone you can buy over the counter. Save your money.

Patient Review

2/6/2012

Locoid Lipocream for Atopic Dermatitis

I've been using Locoid Lipocream for a while now to keep my face clear of acne. Recently, I tried weaning myself off of it and have had problems with my skin since.

Patient Review

9/19/2018

Locoid Lipocream for Itching

This ointment quickly and effectively dealt with my itchy skin, which was especially great because I had tried a few other things that didn't work. Not only that, but it also soothed mosquito bites and other rashes!

Patient Review

5/18/2017

Locoid Lipocream for Psoriasis of Scalp

This treatment helps me a lot when my psoriasis is flaring up. It immediately stops the itching and also clears it up relatively quickly.

Patient Review

6/20/2014

Locoid Lipocream for Atopic Dermatitis

My 8 year old daughter had the Moluscum Contagiosum virus and it caused painful sores on her skin. Within two days of using this ointment, applied with a q-tip, the sores were gone.

Patient Review

8/26/2015

Locoid Lipocream for Skin Condition

I'm so glad this medicine worked for me when nothing else did. My doctor told me last week that it's being taken off the market, which doesn't make any sense to me if it actually works.

Patient Review

5/30/2014

Locoid Lipocream for Skin Condition

This cream actually halted the healing process on my arm after surgery. I had an open wound that didn't close up and form a scab.

Patient Review

10/7/2009

Locoid Lipocream for Atopic Dermatitis

Patient Review

5/18/2017

Locoid Lipocream for Plaque Psoriasis

This cream is the best thing I've found to combat my psoriasis.

4.7

Patient Review

1/28/2012

Locoid Lipocream for Skin Condition

After using a certain facial cream my skin became uncontrollably itchy and red with very tiny rash-like bumps all over my face and neck. After a few days of using this cream my skin stopped itching and became less red. It took a while for the tiny bumps to go away, but it all cleared up within a week!

4.7

Patient Review

11/16/2010

Locoid Lipocream for Rash

This is the only cream that I've found to be effective against my dermatitis. Within one or two days, it will completely get rid of any flare-ups.

Patient Review

10/6/2014

Locoid Lipocream for Rash

I found this to be an effective way to manage my breakouts.

3.3

Patient Review

5/31/2012

Locoid Lipocream for Atopic Dermatitis

I've had eczema my whole life, and it's been really tough. Thankfully, when I was 14 my dermatologist prescribed Locoid. It's the only thing that works for me - two days and the eczema symptoms are gone. I use this as needed to keep flare-ups at bay; it helps me so much in avoiding acne from the steroids often used to treat eczema.

3.3

Patient Review

9/16/2009

Locoid Lipocream for Skin Condition

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Patient Q&A Section about locoid lipocream

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can Locoid be used for itching?

"Locoid is a corticosteroid cream, ointment, or solution used to reduce swelling, itching, and redness caused by various skin conditions. It can also be used to treat severe dandruff."

Answered by AI

What are the side effects of Locoid Lipocream?

"The following side effects may occur when this medication is applied to the skin: stinging, burning, itching, irritation, dryness, redness, or peeling."

Answered by AI

What is the difference between Locoid cream and Locoid Lipocream?

"The proposed product, Locoid Lipocream, is a cream formulation that was developed around 1980 in Germany. The sponsor stated that the new formulation had better cosmetic appeal and would be more acceptable for use in a wider range of skin conditions than the Locoid Cream or Ointment."

Answered by AI

What is Locoid Lipocream used for?

"The text is saying that Locoid Lipocream can be used to treat inflammatory skin disorders in adults, children, and infants who are at least 3 months old. The product is recommended for disorders that are not caused by microorganisms, such as eczema, dermatitis, and psoriasis."

Answered by AI