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SSRI

SSRI Therapy for Depression (CAN-D Trial)

N/A
Recruiting
Led By Owen Wolkowitz, MD
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Females of child-bearing capacity must be non-pregnant (confirmed by urine pregnancy test) and using effective non-hormonal birth control (e.g. abstinence, condoms, IUD)
Age 21-60 and able to give informed consent
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline and week 8
Awards & highlights

CAN-D Trial Summary

This trial will help us understand if there are natural differences in blood levels of certain compounds and genetic markers between patients with depression and healthy adults, and if any such differences relate to memory performance, mood, and neurobiology.

Who is the study for?
This study is for adults aged 21-60 with a current diagnosis of Major Depressive Disorder, experiencing a depressive episode lasting over 6 weeks. Participants must be in good health, not using drugs or certain medications, and women must use non-hormonal birth control. People with neurological disorders, recent concussions, substance abuse issues, or those who are needle-phobic cannot join.Check my eligibility
What is being tested?
The trial examines how blood compounds and genetic markers related to depression may change after eight weeks of treatment with an SSRI (a type of antidepressant). It also looks at the impact on memory performance, mood changes, and gut microbiome compared to healthy individuals without depression.See study design
What are the potential side effects?
While not explicitly listed here, common side effects from SSRIs can include nausea, headaches, sleep disturbances (like insomnia), fatigue or drowsiness; sexual dysfunction; dry mouth; blurred vision; and weight gain.

CAN-D Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am not pregnant and use non-hormonal birth control methods.
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I am between 21 and 60 years old and can legally consent.
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My blood counts are within normal range and I haven't donated blood in the last 8 weeks.
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I have never had a concussion that caused me to black out for more than 10 minutes.

CAN-D Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline and week 8
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline and week 8 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Depression ratings at baseline and Week 8
Serum levels of steroids and neurosteroids at baseline and Week 8
Secondary outcome measures
Serum levels of cytokines and immune markers at baseline and Week 8
Serum levels of oxidative stress markers at baseline and Week 8

CAN-D Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment with SSRIExperimental Treatment1 Intervention
Depressed participants will receive 8 weeks of treatment with one of the following serotonin-specific reuptake inhibitors: fluoxetine (Prozac®), sertraline (Zoloft®), citalopram (Celexa®), escitalopram (Lexapro®) The specific drug used for treatment will be selected by the study clinician based on clinical interviews and the participants preferences. Participants will be monitored for response and side effects by study clinician and will return after 8 weeks for a follow up study visit.

Find a Location

Who is running the clinical trial?

National Institutes of Health (NIH)NIH
2,684 Previous Clinical Trials
6,930,670 Total Patients Enrolled
52 Trials studying Depression
46,770 Patients Enrolled for Depression
National Institute of Mental Health (NIMH)NIH
2,775 Previous Clinical Trials
2,673,516 Total Patients Enrolled
665 Trials studying Depression
251,190 Patients Enrolled for Depression
University of California, San FranciscoLead Sponsor
2,496 Previous Clinical Trials
11,933,621 Total Patients Enrolled
71 Trials studying Depression
28,600 Patients Enrolled for Depression

Media Library

Standard Clinical Care with an SRRI (SSRI) Clinical Trial Eligibility Overview. Trial Name: NCT00285935 — N/A
Depression Research Study Groups: Treatment with SSRI
Depression Clinical Trial 2023: Standard Clinical Care with an SRRI Highlights & Side Effects. Trial Name: NCT00285935 — N/A
Standard Clinical Care with an SRRI (SSRI) 2023 Treatment Timeline for Medical Study. Trial Name: NCT00285935 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

For which type of patient is this clinical trial looking for?

"Patients that meet the following criteria are eligible for this depression trial: being between 21 and 60 years old and a formal diagnosis of depression. So far, around 228 people have been enrolled in the study."

Answered by AI

Is it possible to sign up for this research project?

"That is correct. The information available on clinicaltrials.gov verifies that this study, which was first published on December 1st 2010, is looking for patients right now. In total, 228 individuals are needed at a single site."

Answered by AI

May patients of any age participate in this research?

"In order to meet the requirements for this trial, potential participants must be aged 21-60."

Answered by AI

How many people are going to be included in this clinical research?

"Yes, that is accurate. The listing on clinicaltrials.gov says that the trial is currently ongoing and recruiting patients. The original posting was December 1st 2010, with the most recent update being March 2nd 2022. They are looking for a total of 228 people from one site."

Answered by AI

Who else is applying?

What state do they live in?
California
What site did they apply to?
University of California San Francisco
What portion of applicants met pre-screening criteria?
Met criteria
~35 spots leftby Aug 2026