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Orbital Radiation Therapy for Lymphoma
Study Summary
This trial is studying ultra low dose orbital radiation therapy to treat stage I-IV low grade B-cell lymphoma or mantle cell lymphoma involving the orbit of the eye. This type of radiation therapy uses external beam radiation to destroy cancer cells and may be effective with fewer side effects.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I have chronic lymphocytic leukemia or small lymphocytic lymphoma.I will receive treatment throughout my body after eye radiation, and its timing will be noted.I agree to use contraception or abstain from sex during the study.I have not had chemotherapy for lymphoma in the last 4 weeks.My lymphoma is of an aggressive type, such as DLBCL or grade 3 follicular.I have a pre-existing eye condition affecting my retina.I have had radiation to my eye area before and cannot have more without risking damage.My eye lymphoma is visible on scans or to doctors after a biopsy confirmed it's B cell type.I have a type of slow-growing B cell lymphoma but not CLL/SLL.I have issues in both eyes, but only one has been confirmed with disease.I can understand and agree to the study's details on my own.I am using or willing to use two forms of birth control or am not able to become pregnant.I do not have active lupus or scleroderma.I am a woman who can have children and have a negative pregnancy test.
- Group 1: Treatment (low dose orbital EBRT)
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
What side effects have been commonly reported with Orbital Radiation treatments?
"There is some data supporting the safety of Orbital Radiation, but none yet supporting its efficacy. It received a score of 2."
Are new patients being accepted into this research project?
"According to the latest information available on clinicaltrials.gov, this study is not currently looking for new patients. This trial was first made public on July 6th, 2015 and received its most recent update June 20th, 2022. With that being said, there are 1,814 other trials which ARE actively recruiting participants."
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