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Theophylline for Pseudohypoparathyroidism
Study Summary
This trial will test if theophylline can help people with pseudohypoparathyroidism by causing weight loss, improved glucose tolerance, and slower growth plate closure.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2018 Phase 4 trial • 1670 Patients • NCT02261727Trial Design
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Who is running the clinical trial?
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- I have taken a PDE inhibitor medication in the last 30 days.Your PHQ-9 score is 15 or higher, or you have had serious thoughts of harming yourself in the past month.I am considered obese based on my BMI.I have been diagnosed with congestive heart failure.I have an active stomach ulcer.I am 13 years old or older.I have a history of seizures not caused by low calcium.I have a history of irregular heartbeats, not including slow heartbeat.I am taking medication that affects theophylline levels.You have not been treated for low thyroid hormone levels.I have been diagnosed with PHP, showing specific symptoms like hormone resistance or unique hand features.You currently smoke cigarettes or abuse alcohol.My liver is not working well (AST or ALT levels are high).I have not had major depression, suicide attempts, or severe psychiatric disorders recently.
- Group 1: Theophylline
- Group 2: Placebos
- Approved for 5 Other Conditions - This treatment demonstrated efficacy for 5 other conditions.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are patients who are over 45 years of age eligible for this research project?
"Eligibility for this clinical trial is based on age, with participants needing to be between 13 and 99 years old."
Is it legal to market and sell Theophylline in the United States?
"Theophylline's safety is supported by some data, making it a 2 on our 1-3 scale."
Could you please share Theophylline's clinical trial history?
"There are currently 6 ongoing clinical trials studying Theophylline. Out of these, 2 have reached Phase 3 status. Most studies related to Theophylline are based in Nashville, but there are a total of 7 locations running trials for this medication."
What medical conditions is Theophylline used to treat?
"Theophylline is an effective treatment for emphysema, bronchoconstriction, and chronic bronchial inflammation."
Can I join this medical study?
"Researchers conducting this trial are looking for 34 individuals that have pseudohypoparathyroidism and meet the age criteria of being between 13 and 99 years old. Most importantly, potential participants must also suffer from obesity as defined by having a BMI in the 95th percentile or higher for their age and gender group or having a body weight 30 kilograms per square meter."
Is this research still looking for volunteers?
"Yes, the trial is still active and recruitment information can be found on clinicaltrials.gov. This particular study was first made available on September 1st, 2018 and has since been updated on August 15th, 2022. They are currently looking for 34 participants total at a single site."
How many people suffering from this ailment will be given the chance to try this new treatment?
"That is correct. The clinical trial listing on the website shows that this research project is actively seeking participants. This study was originally posted on September 1st, 2018 and was updated August 15th, 2022. Currently, 34 patients are needed to be enrolled at a single site."
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