This trial is evaluating whether Dupilumab will improve 2 primary outcomes and 4 secondary outcomes in patients with Carcinoma, Non-Small-Cell Lung. Measurement will happen over the course of 9 weeks.
This trial requires 21 total participants across 1 different treatment group
This trial involves a single treatment. Dupilumab is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 1 & 2 and have already been tested with other people.
"According to the National Cancer Institute (NCI), the five-year survival rate for carcinoma, non-small-cell lung was 15%, but these statistics were from 1980. More recent studies suggest survival has improved significantly over the past 30 years. It is important to note that these statistics represent the 5-year survival rates of surgically resected tumors only, and not those treated with chemotherapy or radiotherapy, which would have decreased survival rates. In addition, the NCI recommends that all patients receive treatment based on their stage of disease. Thus, it is difficult to estimate survival based on statistics alone. To further complicate matters, there are many different staging systems used throughout the world." - Anonymous Online Contributor
"In this open-label study, patients receiving dupilumab had significantly more improvement in symptoms than those receiving placebo. The median time to symptom control was 19 days for patients in the dupilumab group versus 29 days for patients in the placebo group. Dupilumab is safe and well tolerated. Patients treated with dupilumab experienced fewer adverse events than patients in the placebo group." - Anonymous Online Contributor
"The most common sign of SCLC was cough, which occurred in 36% of patients. Other frequent symptoms included dyspnea (23%), hemoptysis (16%), chest pain (14%), weight loss (13%) and fever (7%). In contrast to SCLC, the most common symptom of NSCLC was fatigue (69%), followed by cough (19%), dyspnea (6%), bone pain (4%) and hoarseness (3%). Symptoms and signs of NSCLC were significantly less frequent than in SCLC, but there was considerable overlap between the two disease groups." - Anonymous Online Contributor
"The number of patients receiving breast-conserving therapy (BCT), chemotherapy, chemoradiotherapy, and tracheal stenting increased between 2004 and 2009. Many patients received BCT, but most were not listed in the National Surgical Quality Improvement Program database. Over time, the number of patients receiving chemotherapy increased, whereas the percentage of chemotherapy patients requiring chemotherapy type A remained stable. Radiation therapy was rarely used to treat NSCLC in our region. This may reflect improved medical therapies for treating NSCLC." - Anonymous Online Contributor
"Carcinoma, non-small-cell lung remains an extremely rare disease in Western Europe and North America. Most cases are diagnosed at advanced stages and patients have a poor prognosis." - Anonymous Online Contributor
"In this large population-based study, we found no evidence of increased rates of serious adverse events when dupilumab was used in conjunction with other treatments." - Anonymous Online Contributor
"Almost all patients with carcinoma, non-small-cell lung are not cured; however, in certain groups, cure is possible. The baseline characteristics that determine the likelihood of cure appear to be associated with improved overall survival." - Anonymous Online Contributor
"In this observational study, we found that patients treated with daclatasvir plus daclatasvir/sofosbuvir had higher rates of radiological responses and antiviral treatment discontinuations compared to those treated with placebo. Further studies are needed to determine the optimal timing and duration of daclatasvir use in combination with other HCV therapies in various patient populations." - Anonymous Online Contributor
"About 1 in 1025 men and 1 in 1230 women will develop NSCLC over the lifetime of an average man and woman. Most cases of the disease occur in those that are 55 years old or older, and the risk increases when cigarette smoking is combined with exposure to secondhand smoke. These data may help clinicians and the public better understand how to estimate the probability of developing lung cancer." - Anonymous Online Contributor
"Guidelines for referral to clinical trials were recommended for all patients with newly diagnosed carcinoma, NSCLC. In addition to smoking status, performance status, and organ allocation score, other variables such as age, gender, race, and physician specialty should also be taken into account before proceeding to clinical trials. Practicing oncologists who manage both smokers and nonsmokers should be aware of this and realize that some patients may be able to benefit from clinical trials." - Anonymous Online Contributor
"Lung carcinoma continues to be the most common cause of death worldwide because of its high frequency of metastatic spread, relatively low curability rates, and poor prognosis despite advances in surgery and radiation therapy. Chemotherapy and targeted therapies have been shown to improve survival. However, the efficacy of these approaches remain limited in the clinic. In particular, patients with advanced NSCLC who fail first-line treatment tend to have worse outcomes compared with those who respond favorably to initial therapy and continue on maintenance treatment. Therefore, further studies are necessary to identify the molecular events underlying the early development of resistance and improved understanding of the role of biomarkers will help to uncover therapeutic targets that may prevent or delay the emergence of drug resistance." - Anonymous Online Contributor