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What is Lanoxicaps
DigoxinThe Generic name of this drug
Treatment SummaryDigoxin is a medication used to treat atrial fibrillation and heart failure symptoms. It was first approved by the FDA in 1954 and comes from the foxglove plant, which was studied by an English physician and botanist in the 1780s. This plant has been used to make medications since the 1250s, and Digoxin is one of the oldest cardiovascular medications still in use today.
Digoxinis the brand name
Lanoxicaps Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Digoxin
Digoxin
1975
190
Effectiveness
How Lanoxicaps Affects PatientsDigoxin is a medication that can help people with an irregular heartbeat (atrial fibrillation) by increasing the force of their heartbeat and slowing down their heart rate. Studies have shown that taking digoxin can lead to improved exercise capacity and fewer hospitalizations or emergency visits due to heart failure. However, it has a narrow therapeutic window and can cause potentially fatal side effects, such as ventricular fibrillation or complete heart block, in individuals who have pre-existing sinus node disease or AV block and take digoxin.
How Lanoxicaps works in the bodyDigoxin helps the heart work better by decreasing the heart rate and increasing the force of heart muscle contractions. It does this by blocking a protein that regulates the entry and exit of sodium, potassium and calcium into and out of cells. This increases the amount of sodium and calcium in the cells of the heart muscle, making it stronger. Digoxin also stimulates the parasympathetic nervous system, which decreases neurohormonal activity and lowers the heart rate.
When to interrupt dosage
The suggested dose of Lanoxicaps is contingent upon the diagnosed condition, including Chronic Atrial Fibrillation, mild, moderate Heart Failure and Congestive Heart Failure. The dosage fluctuates as per the method of delivery (e.g. Oral or Liquid - Oral) featured in the table beneath.Condition
Dosage
Administration
Ventricular Arrhythmia
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Heart failure
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Chronic Atrial Fibrillation
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Congestive Heart Failure
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Myocardial contractility
0.125 mg, , 0.25 mg, 0.25 mg/mL, 0.05 mg/mL, 0.1875 mg, 0.0025 mg, 0.00125 mg, 0.0625 mg, 0.1 mg/mL, 0.2 mg, 0.1 mg, 0.5 mg/mL
, Oral, Tablet, Tablet - Oral, Injection, solution, Intramuscular; Intravenous; Parenteral, Injection, solution - Intramuscular; Intravenous; Parenteral, Solution - Oral, Solution, Intramuscular; Intravenous, Injection, solution - Intramuscular; Intravenous, Liquid, Liquid - Intramuscular; Intravenous, Liquid - Oral, Injection, Injection - Intramuscular; Intravenous, Capsule - Oral, Capsule, Capsule, liquid filled, Capsule, liquid filled - Oral
Warnings
Lanoxicaps has three contraindications, and therefore should not be utilized while encountering any of the conditions outlined in the following table.Lanoxicaps ContraindicationsCondition
Risk Level
Notes
Ventricular Fibrillation
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Digoxin may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Digoxin may interact with Pulse Frequency
Common Lanoxicaps Drug Interactions
Drug Name
Risk Level
Description
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Hydroxyzine.
Mobocertinib
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Mobocertinib.
Revefenacin
Major
Digoxin may decrease the excretion rate of Revefenacin which could result in a higher serum level.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Ziprasidone.
Abexinostat
Minor
The risk or severity of QTc prolongation can be increased when Digoxin is combined with Abexinostat.
Lanoxicaps Toxicity & Overdose RiskThe lowest toxic dose of digoxin for women is 100 micrograms per kilogram, and for men is 75 micrograms per kilogram. In rats, the lowest toxic dose is 28270 micrograms per kilogram. Taking too much digoxin can lead to nausea, vomiting, changes in vision, and irregular heartbeats. People who are older, have a lower body weight, or have decreased kidney function and electrolyte imbalances are at higher risk of digoxin toxicity.
Lanoxicaps Novel Uses: Which Conditions Have a Clinical Trial Featuring Lanoxicaps?
308 active trials are currently in progress to assess the ability of Lanoxicaps to address Cardiac Arrhythmias, boost Myocardial contractility, and manage Congestive Heart Failure.Condition
Clinical Trials
Trial Phases
Congestive Heart Failure
315 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1, Phase 4
Myocardial contractility
0 Actively Recruiting
Chronic Atrial Fibrillation
2 Actively Recruiting
Not Applicable
Ventricular Arrhythmia
2 Actively Recruiting
Not Applicable
Heart failure
0 Actively Recruiting
Lanoxicaps Reviews: What are patients saying about Lanoxicaps?
5Patient Review
6/7/2009 I had used this type Lanoxin for years without any problems. They took it off the market and I have since had severe reactions to regular Lanoxin. I want to know if it has been put back on the market and if it is now available.
5Patient Review
7/10/2008 I'm extremely disappointed that Glaxo Smith Kline has stopped making this medication. It helped me and I know it's helped other people too. We should have been notified ahead of time so we could have prepared.
5Patient Review
11/23/2009 I've taken Lanoxicaps for over a decade and it's been incredibly effective for me. I had to switch to the Lanoxin form of the drug when Lanoxicaps were taken off the market, but I've since had allergic reactions and other bad reactions to the tablet. It's really unfortunate that there are now fewer medical options for patients with serious cardiac diseases.
5Patient Review
6/3/2008 I was very upset when they took Lanoxicaps off the market.
4.7Patient Review
12/11/2007 I'm not sure why this product is no longer available, but my doctor switched me to Atenolol.
Patient Q&A Section about lanoxicaps
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What's Digoxin used for?
"UK
Digoxin is a medication used to treat irregular heartbeats."
Answered by AI
What's the generic name for Digoxin?
"The oral tablet form of digoxin is available as both a generic drug and a brand-name drug called Lanoxin. An oral solution of digoxin is also available. Digoxin is used to treat atrial fibrillation, mild to moderate heart failure in adults, and heart failure in children."
Answered by AI
What is Lanoxin used for?
"Digoxin is a medication that is used to treat heart failure and certain types of irregular heartbeat. treating heart failure with digoxin can help improve the patient's ability to walk and exercise, as well as the strength of the heart."
Answered by AI
What are the side effects of Digoxin?
"... , Swelling of your liver ...
You may have Covid-19 if you're feeling confused, dizzy or generally unwell. Other symptoms include feeling or being sick (nausea or vomiting) and loss of appetite, diarrhoea, changes in your vision (including blurred vision and not being able to look at bright light), skin rashes, swelling of your liver."
Answered by AI