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Exercise for Atrial Fibrillation (ACUTE-AF Trial)

N/A

Recruiting

Led By Jennifer Reed, PhD

Research Sponsored by Ottawa Heart Institute Research Corporation

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Self-reports being symptomatic in the past 4 weeks

Paroxysmal and Persistent AF

Timeline

Screening 3 weeks

Treatment Varies

Follow Up through study completion, an average of 1.5 years

Awards & highlights

ACUTE-AF Trial Summary

This trial will test whether exercise can help relieve symptoms in people with atrial fibrillation.

Who is the study for?

This trial is for men and women over 40 with symptomatic atrial fibrillation (AF) who can exercise safely. Participants must have had AF symptoms recently, women should be post-menopausal, and all must understand English or French. Excluded are those already exercising regularly, with unstable heart conditions or severe diabetes, unable to use a smartphone or the internet, or with certain cardiac devices.Check my eligibility

What is being tested?

The study tests how different types of exercise affect short-term changes in AF symptoms. It compares moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), and no vigorous exercise over one week in a randomized crossover design where participants will try each condition.See study design

What are the potential side effects?

While specific side effects aren't listed for this type of physical activity intervention, general risks may include muscle soreness, fatigue, and potential exacerbation of AF symptoms during or after exercise.

ACUTE-AF Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have felt symptoms in the last 4 weeks.

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I have irregular heartbeats that come and go or persist.

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I am 40 years old or older.

ACUTE-AF Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ through study completion, an average of 1.5 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~through study completion, an average of 1.5 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and through study completion, an average of 1.5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Feasibility of the pilot study - Adverse events

Feasibility of the pilot study - Participant fidelity

Feasibility of the pilot study - Recruitment and consent rate

+2 more

Secondary outcome measures

AF status measured daily with a KardiaMobile device

AF symptoms self-reported with a 7-day patient symptom questionnaire

ACUTE-AF Trial Design

3Treatment groups

Experimental Treatment

Active Control

Group I: Moderate Intensity Continuous Training (MICT)Experimental Treatment1 Intervention

Participants will do 3 sessions of moderate-intensity continous exercise training over 7 days

Group II: High Intensity Interval Training (HIIT)Experimental Treatment1 Intervention

Participants will do 3 sessions of high-intensity interval training over 7 days

Group III: RestActive Control1 Intervention

Participants will abstain from doing moderate- to high-intensity interval training over 7 days

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

High-intensity interval training (HIIT)

2016

N/A

~270

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Ottawa Heart Institute Research CorporationLead Sponsor

188 Previous Clinical Trials

92,400 Total Patients Enrolled

23 Trials studying Atrial Fibrillation

6,655 Patients Enrolled for Atrial Fibrillation

Jennifer Reed, PhDPrincipal InvestigatorOttawa Heart Institute Research Corporation

4 Previous Clinical Trials

246 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is this research study currently accepting participants?

"Affirmative. Clinicaltrials.gov has information that confirms this clinical trial is seeking enrolment from potential participants, having been posted on February 8th 2022 and edited lastly on November 29th 2022. The study necessitates 36 patients to be recruited at one medical centre."

Answered by AI

What is the aggregate figure of people engaging in this experiment?

"Affirmative. The clinicaltrials.gov website provides evidence that, as of November 29th 2022, this study is still actively seeking applicants. Since its post on February 8th 2022 it has been looking for 36 participants at just one medical centre."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation

Jennifer Reed 2022. "Acute Responses to Exercise in Females and Males With Symptomatic Atrial Fibrillation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05085860.