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Trials for Anorexia Nervosa Patients
Neuromodulation
TMS for Anorexia
This trial uses a type of brain stimulation called theta burst rTMS to treat adults with Anorexia Nervosa. The treatment targets a specific brain area involved in obsessive and compulsive behaviors. The goal is to reduce these symptoms and improve patients' eating habits. Theta burst stimulation (TBS) is a newer and more effective form of repetitive transcranial magnetic stimulation (rTMS) that has shown promise in treating neuropsychiatric disorders.
Monoclonal Antibodies
Romosozumab for Anorexia Nervosa
This trial tests if romosozumab can help women with anorexia nervosa build stronger bones over a year, followed by alendronate to maintain the strength. The goal is to see if this combination improves bone health. Romosozumab is a treatment that both increases bone formation and decreases bone breakdown, primarily used to reduce fracture risk in postmenopausal women with osteoporosis.
Trials for Eating Disorders Patients
Neuromodulation
TMS for Anorexia
This trial uses a type of brain stimulation called theta burst rTMS to treat adults with Anorexia Nervosa. The treatment targets a specific brain area involved in obsessive and compulsive behaviors. The goal is to reduce these symptoms and improve patients' eating habits. Theta burst stimulation (TBS) is a newer and more effective form of repetitive transcranial magnetic stimulation (rTMS) that has shown promise in treating neuropsychiatric disorders.
Monoclonal Antibodies
Romosozumab for Anorexia Nervosa
This trial tests if romosozumab can help women with anorexia nervosa build stronger bones over a year, followed by alendronate to maintain the strength. The goal is to see if this combination improves bone health. Romosozumab is a treatment that both increases bone formation and decreases bone breakdown, primarily used to reduce fracture risk in postmenopausal women with osteoporosis.
Psychedelic
Psilocybin Therapy for Anorexia Nervosa
This trial is testing a treatment using psilocybin, a substance from certain mushrooms, to help people with anorexia nervosa. The treatment aims to change brain function to improve mental health, especially for those who haven't responded well to other treatments. Psilocybin is a naturally occurring psychedelic that has shown promise in treating various psychiatric disorders, including mood and substance use disorders.
Trials With No Placebo
Neuromodulation
TMS for Anorexia
This trial uses a type of brain stimulation called theta burst rTMS to treat adults with Anorexia Nervosa. The treatment targets a specific brain area involved in obsessive and compulsive behaviors. The goal is to reduce these symptoms and improve patients' eating habits. Theta burst stimulation (TBS) is a newer and more effective form of repetitive transcranial magnetic stimulation (rTMS) that has shown promise in treating neuropsychiatric disorders.
Antipsychotic
Olanzapine vs Megestrol Acetate for Cancer-Related Anorexia
This trial tests whether olanzapine or megestrol acetate is better at increasing appetite in patients with advanced cancer. These patients often struggle with eating and weight loss. Both medications aim to make them feel hungrier, helping them eat more and gain weight. Megestrol acetate is known for its effectiveness in increasing appetite in patients with cancer.
Psychedelic
Psilocybin Therapy for Anorexia Nervosa
This trial is testing a treatment using psilocybin, a substance from certain mushrooms, to help people with anorexia nervosa. The treatment aims to change brain function to improve mental health, especially for those who haven't responded well to other treatments. Psilocybin is a naturally occurring psychedelic that has shown promise in treating various psychiatric disorders, including mood and substance use disorders.
Dietary Supplement
Metabolic Diet for Anorexia Nervosa
This trial will test a new diet designed to help women with anorexia nervosa remain weight-stable. The diet will be given to women who have been recently restored to normal weight, as well as women with no history of eating disorders, to see if it is effective and safe.
Behavioral Intervention
Cognitive Remediation Therapy for Anorexia
This trial tests if adding Cognitive Remediation Therapy (CRT) to Family Based Treatment (FBT) helps adolescents with Anorexia Nervosa (AN) by making their thinking more flexible. The goal is to see if this combined approach improves treatment outcomes. Cognitive Remediation Therapy (CRT) has been developed and tested for adolescents with anorexia nervosa to improve cognitive flexibility and holistic processing.
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Frequently Asked Questions
Introduction to anorexia
What are the top hospitals conducting anorexia research?
In the realm of anorexia research, several notable hospitals are leading the way in clinical trials aimed at understanding and treating this challenging condition. Among them is the University of California San Diego, located in sunny San Diego, with seven active anorexia trials and a total of eight trials conducted to date. Since embarking on their first recorded trial in 2015, they have been committed to shedding light on this complex disorder. Meanwhile, over in Tulsa, Oklahoma, we find Laureate Institute for Brain Research making significant strides as well. With four ongoing anorexia trials and five completed ones since their inaugural study also launched in 2015.
On the East Coast, New york State Psychiatric Institute has dedicated its efforts to combatting anorexia with two active clinical trials underway and a remarkable seventeen previous studies conducted thus far. Their exploration into this condition began back in 2003, showcasing their long-standing commitment to improving treatment options for those affected by this debilitating illness.
Furthermore found within New York City itself is the Department of Psychiatry's Eating and Weight Disorders Program where two current explorations are tackling potential solutions while establishing novel understandings aboutanorexi; albeit only just venturing out through recording its initial experiment as recent as2022.Throughout all these years Stanford University has also remained consistent contributors towarded advancement against such cases; already having evaluated eight experiments before now conducting another couple today.It is crucial to recognize that these institutions' endeavors not only provide hope for individuals struggling with anorexia but signify continued progress towards unraveling complexities behind it - pushing us closer to effective treatments that can transform lives.
The combined efforts of these top hospitals underscore our collective determination across different parts of the United States when it comes addressing one pressing issue like eating disorders which poses devastating risks if left unaddressed or untreated nationwide
Which are the best cities for anorexia clinical trials?
When it comes to anorexia clinical trials, several cities have emerged as leading hubs for research and innovative treatments. San Diego, California leads the way with 8 active trials, exploring interventions such as Therapeutic Ketogenic Diet, Cannabidiol, and bromocriptine. New york City closely follows with 6 ongoing studies focusing on High-frequency repetitive transcranial magnetic stimulation (HF-rTMS), SilverCloud Health Mobile Intervention, and Psilocybin therapy. Additionally, Tulsa in Oklahoma boasts 4 active trials examining Isoproterenol, Vibrant capsule, and Floatation-REST plus usual care interventions. These cities offer individuals struggling with anorexia access to cutting-edge clinical trials that may pave the way towards improved treatment options and better outcomes.
Which are the top treatments for anorexia being explored in clinical trials?
Current clinical trials are exploring several potential treatments for anorexia. Olanzapine, a medication introduced in 2000, is being tested in two active trials and has been involved in eight all-time trials focused on anorexia treatment. Isoproterenol, listed for the first time in 2015, is also under investigation with two ongoing trials and a total of two past anorexia trials. Additionally, researchers are examining the effectiveness of therapeutic ketogenic diets through one active trial. Newer options include ponsegromab and cannabidiol; each has one active trial and one historical trial dedicated to addressing anorexia symptoms. These findings provide hope that novel approaches may soon emerge to improve outcomes for individuals grappling with this challenging disorder.
What are the most recent clinical trials for anorexia?
Recent clinical trials are shedding light on potential treatment options for individuals suffering from anorexia. One notable trial focused on the use of ponsegromab, a promising drug currently in Phase 2 testing, which aims to address the underlying causes of this eating disorder. Another study explored the therapeutic potential of psilocybin, also in Phase 2 trials, as a novel approach to treating anorexia and its associated psychological aspects. Additionally, Naltrexone Hydrochloride has shown promise in both Phase 2 and Phase 3 trials for reducing symptoms and improving outcomes for those with anorexia. These advancements offer hope for improved interventions tailored specifically to individuals battling this complex condition.
What anorexia clinical trials were recently completed?
Several notable clinical trials for anorexia have recently concluded, offering potential insights into improved treatment options. In May 2021, Pfizer completed a trial examining the efficacy of PF-06946860 in addressing this challenging eating disorder. Just a month prior, Homeostasis Therapeutics successfully finished their trial investigating Ketamine Hcl 50Mg/Ml Inj as a potential therapy for anorexia. Notably, in April 2021 and August 2019 respectively, both Johns Hopkins University and Helsinn Healthcare SA completed separate trials exploring the use of Psilocybin and Anamorelin Hydrochloride in treating anorexia. These collective efforts signify significant progress towards better understanding and managing this complex condition.