Olanzapine and Mirtazapine for Weight Loss in Advanced Stage Cancer
Trial Summary
What is the purpose of this trial?
This trial is testing two medications, olanzapine and mirtazapine, to see which one helps cancer patients keep their weight and appetite. Cancer patients often lose weight and appetite, and these drugs might help by making them feel better emotionally and physically. Olanzapine and mirtazapine have been shown to improve appetite and reduce nausea in cancer patients, which can help with weight maintenance.
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot take Marinol within two weeks of joining the study. Patients on Dexamethasone are allowed to participate.
Is the combination of olanzapine and mirtazapine safe for humans?
How do the drugs olanzapine and mirtazapine help with weight loss in advanced cancer patients?
Olanzapine and mirtazapine are unique because they not only help with nausea and appetite increase in advanced cancer patients but also have fewer side effects and drug interactions compared to other treatments. They are also easier to use with once- or twice-daily dosing and are more cost-effective than standard nausea medications.13456
Eligibility Criteria
This trial is for adults with advanced cancer who have lost more than 5% of their weight unintentionally over the last 3-6 months, despite nutritional support. They must be able to consent, communicate effectively, and have a life expectancy of at least 4 months. Those on dexamethasone or undergoing chemotherapy can join. People using Marinol recently, with abnormal heart rhythms or liver function, or primarily fed intravenously cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either Olanzapine or Mirtazapine to assess their effectiveness in preventing weight and appetite loss
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Mirtazapine
- Olanzapine
Mirtazapine is already approved in United States, European Union for the following indications:
- Major depressive disorder
- Major depressive episodes
Find a Clinic Near You
Who Is Running the Clinical Trial?
Englewood Hospital and Medical Center
Lead Sponsor