Cognitive Remediation Therapy for Anorexia

Phase-Based Estimates
1
Effectiveness
1
Safety
Children's Hospital of Philadelphia, Philadelphia, PA
+1 More
Cognitive Remediation Therapy - Behavioral
Eligibility
Any Age
All Sexes
Eligible conditions
Anorexia

Study Summary

Shifting Perspectives R33 Phase: Enhancing Outcomes in Anorexia Nervosa With CRT

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Eligible Conditions

  • Anorexia
  • Anorexia Nervosa

Treatment Effectiveness

Effectiveness Estimate

1 of 3

Study Objectives

This trial is evaluating whether Cognitive Remediation Therapy will improve 12 primary outcomes in patients with Anorexia. Measurement will happen over the course of Baseline, during treatment, end of treatment.

Baseline, during treatment, end of treatment
Change in behavioral flexibility (amount consumed)
Change in behavioral flexibility (eating disorder behaviors)
Change in category switching flexibility
Change in eating disorder symptomology
Change in executive functioning
Change in flexibility
Change in response inhibition
Change in self-reported inhibition control
Change in self-reported set-shifting
Change in set-shifting
Change in shifting accuracy
Rate of weight gain

Trial Safety

Trial Design

2 Treatment Groups

Family Based Treatment (FBT)
FBT w/ Adolescent-focused Cognitive Remediation Therapy

This trial requires 96 total participants across 2 different treatment groups

This trial involves 2 different treatments. Cognitive Remediation Therapy is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.

FBT w/ Adolescent-focused Cognitive Remediation TherapyFamily Based Treatment with Adolescent-focused Cognitive Remediation Therapy (CRT): Families will receive 15 sessions of FBT over six months. The first 9 sessions of FBT will be preceded by adolescent-focused CRT.
Family Based Treatment (FBT)
Behavioral
Families will receive 15 sessions of FBT alone.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Remediation Therapy
2014
Completed Phase 4
~840
Family Based Treatment
2019
Completed Phase 1
~130

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline, during treatment, end of treatment
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline, during treatment, end of treatment for reporting.

Closest Location

Children's Hospital of Philadelphia - Philadelphia, PA

Eligibility Criteria

This trial is for patients born any sex of any age. You must have received 1 prior treatment for Anorexia or the other condition listed above. There are 10 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Inclusion Criteria: Adolescents
Age 12-18
Currently meets Diagnostic and Statistical Manual-5 criteria for Anorexia Nervosa
Medically stable for outpatient treatment
Fluent in English
No co-morbid condition that would exclude participation
Medical clearance from primary care physician and permission to speak to Primary Care Physician about clinical issues
Biological parent or primary caregiver willing to engage in treatment and who lives with the adolescent
Inclusion Criteria: Parents
Age >18

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What are the common side effects of cognitive remediation therapy?

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The current study reveals a wide range of side effects in patients undergoing CRT treatment, and can therefore help clinicians in choosing the most appropriate treatment for the individual patient.

Unverified Answer

What is the latest research for anorexia?

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The use of social media, such as Twitter, as support structures for women during weight loss is an effective tool to promote personal weight loss.

Unverified Answer

What are the signs of anorexia?

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Symptoms of weight loss, fatigue, sleep disturbances, loss of appetite, and constipation are found in a substantial proportion of cancer patients. They are independent of age, cancer treatment, cancer stage, and duration of symptom onset. In fact, they occur at the same time as other well-known symptoms of cancer. The exact time or cause of their development is unknown. They may be caused by chemotherapy, disease progression, or treatment interruption or alterations in nutrition. If patients have a decrease in appetite, the nutritional status deteriorates due to lack of food intake.

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How many people get anorexia a year in the United States?

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The incidence of anorexia decreases linearly with age, with the lowest incidence seen in women in the 18-24 age group. The highest prevalence is among women over 55, and many of them will have had anorexia in the past year. The prevalence of anorexia among men is less than 2%. The most common reasons for a change in symptom reporting were concerns about nutrition, weight loss, or body shape. Most anorexia patients seek treatment voluntarily. The most effective prevention method is to educate people about the consequences of anorexia.

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What is anorexia?

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Anorexia is a disease that can affect any age, but primarily affects young girls. It typically arises from the loss of appetite and can also be accompanied by nausea, vomiting, restlessness and dehydration. It mainly affects younger girls.

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What are common treatments for anorexia?

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Common treatments for anorexia include food restriction, behavior therapy and psychotherapy. In the past, behavioral therapy has been the most frequently used intervention in clinical treatment in the United States. For the treatment of anorexia, behavior therapies utilize group work and home training programs to treat patients who have restrictive anorexia. In some cases, group work has been more effective than individually tailored programs. The use of psychosocial interventions focuses on psychotherapy that facilitates individuals to gain increased mastery over illness. Psychotherapeutic interventions for people with anorexia can include family therapy, individual therapy, and interpersonal therapy.

Unverified Answer

What causes anorexia?

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Lack of food has a profound effect on the body's physiology. This may induce the genesis of anorexia. When anorexia is properly understood, the causes can be effectively treated. The following steps may be helpful in preventing the onset of anorexia in hospitalized patients.

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Can anorexia be cured?

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The prevalence of anorexia at the initial assessment of a general adolescent psychiatric clinic was low, even when the symptom of anorexia occurred very close to an acute psychiatric episode: in an almost 1% of adolescents who were referred because of an acute mental illness. Nevertheless, if anorexia is present in a young adolescent it can hardly be cured with conventional psychiatric treatment. Moreover, it would be necessary to implement a systematic follow up of this group of adolescents to monitor its clinical course over time.

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Have there been other clinical trials involving cognitive remediation therapy?

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The use of an MRT program for treatment of PTSD is an intriguing avenue. Additional testing is needed to explore the benefits of MRT and to determine the effect of MRT in a more homogeneous sample (with similar baseline scores). In particular, further studies are needed to confirm that the improvement of the performance in the memory tests results from the clinical improvement of PTSD symptoms with cognitive-behavioral therapies and to ascertain to what extent the reduction of the post-treatment neurocognitive deficits (executive dysfunction) is due to clinical recovery and/or the improvement of PTSD.

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What are the latest developments in cognitive remediation therapy for therapeutic use?

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Cognitive remediation therapies can be helpful to patients with anorexia nervosa and will likely help with long-term recovery. The most effective interventions can be obtained from research, the clinical expertise of therapists, and the patient's strengths and weaknesses.

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Is cognitive remediation therapy safe for people?

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In a small sample of people with severe depression and learning difficulties, CRT was considered to be safe and acceptable despite the lack of controlled trials. However, the lack of control groups and low rates of completion make it difficult to interpret the findings.

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Does anorexia run in families?

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The majority of family members with anorexia have a family history of anorexia and the majority of the family members with anorexia have a history of other psychiatric illnesses. The psychiatric illness history seems to be the major predictor of anorexia.

Unverified Answer
See if you qualify for this trial
Get access to this novel treatment for Anorexia by sharing your contact details with the study coordinator.