Nerve Fiber Stimulation for Alcoholism
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if certain types of stimulation can reduce stress and anxiety in individuals with Alcohol Use Disorder (AUD). Researchers are testing two methods: C Tactile Fiber Stimulation, which uses gentle touch to release feel-good hormones, and Heat Stimulation, which applies heat to potentially ease stress. Participants will be assigned to different groups to try these methods, and their stress and cravings will be measured. This trial suits those who have experienced AUD in the past six months. As a Phase 1 trial, the research focuses on understanding how the treatment works in people, offering participants the opportunity to be among the first to receive this innovative approach.
Do I need to stop my current medications for this trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that this nerve fiber stimulation technique is safe for humans?
Research has shown that a gentle touch, known as C Tactile (CT) fiber stimulation, can improve mood. One study found that this type of touch can help people with Alcohol Use Disorder (AUD) feel better and less stressed, suggesting it might be safe and comfortable for use.
In contrast, using heat as a treatment carries some risks. Evidence shows that alcohol can alter how people perceive heat, sometimes increasing sensitivity. However, research also indicates that alcohol can reduce heat pain in controlled settings.
Both treatments are in the early testing stages, with researchers primarily assessing their safety. The current goal is to ensure these methods are safe before evaluating their effectiveness. While the results are promising, further research is needed to fully confirm their safety.12345Why are researchers excited about this trial's treatments?
Most treatments for alcoholism, like medications and behavioral therapies, aim to reduce cravings or manage withdrawal symptoms. However, this new approach using nerve fiber stimulation is unique because it targets specific nerve fibers in the skin, known as C tactile fibers, which might influence the brain's reward system differently. Researchers are excited because this method could offer a non-invasive alternative with potentially fewer side effects compared to medications. The combination of active C tactile fiber and heat stimulation may also provide a novel way to modulate neural pathways associated with addiction, offering hope for more effective and accessible treatments.
What evidence suggests that this trial's treatments could be effective for alcoholism?
This trial will compare different methods of nerve fiber stimulation for Alcohol Use Disorder (AUD). Research has shown that stimulating certain nerve fibers related to comfort, such as through C Tactile Fiber Stimulation, can help reduce heart rate changes caused by alcohol triggers in people with AUD, potentially having a calming effect during early recovery. Additionally, using heat stimulation to target specific stress-related channels in the body has shown promise in reducing problematic drinking. In one study, participants experienced a 14% decrease in problematic drinking and an 11% reduction in cravings after using heat therapy. Both methods focus on reducing stress and anxiety, which are important in managing AUD. These findings suggest potential benefits for reducing alcohol cravings and stress in people with AUD. Participants in this trial will receive either active or placebo versions of these treatments to evaluate their effectiveness.36789
Who Is on the Research Team?
charles chabal, MD
Principal Investigator
soovu labs
Are You a Good Fit for This Trial?
This trial is for individuals who have had Alcohol Use Disorder (AUD) within the last six months. It's not suitable for those with unstable medical or psychological conditions.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive experimental stimulation of TRPV-1 channels and CT fibers, followed by a stressor and further stimulation
Follow-up
Participants are monitored for safety and effectiveness after treatment, with assessments at 30 and 60 minutes post-treatment
What Are the Treatments Tested in This Trial?
Interventions
- C Tactile Fiber Stimulation
- Heat Stimulation
Find a Clinic Near You
Who Is Running the Clinical Trial?
Soovu Labs Inc.
Lead Sponsor