HOLA Program for Preventing Cognitive Decline

(HOLA-CD Trial)

Overseen By Natalie Ferras, MS, MHC

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Miami

Disqualifiers: Neurodegenerative disorders, Cognitive impairment, Brain trauma, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

Duration: 16 weeks

30 Participants Needed

Trial Summary

What is the purpose of this trial?

The purpose of this study is to look at the best ways to prevent cognitive decline (loss of memory and/or functioning) in midlife and older Latino adults living with HIV.

Research Team

Daniel Jimenez, Ph.D.

Principal Investigator

University of Miami

Eligibility Criteria

This trial is for Latino adults over 50 living with HIV who have their viral load under control. They must be able to walk and give informed consent, but can't join if they're undergoing cancer treatment, have significant hearing or vision loss, a history of serious brain trauma, any neurodegenerative diseases like Alzheimer's, or conditions that make exercise unsafe.

Inclusion Criteria

I am 50 years old or older.

I have given my consent to participate.

I am HIV positive with a viral load under 200 copies/mL.

Exclusion Criteria

I have been diagnosed with a neurodegenerative disorder or dementia.

I cannot walk 10 meters by myself.

I do not have conditions affecting my thinking or senses, nor am I currently on cancer treatment, and I've never had a severe brain injury.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive a multicomponent intervention for 16 weeks led by a community health worker to help prevent cognitive decline

16 weeks

Follow-up

Participants are monitored for changes in neurocognitive impairment, physical activity, psychosocial functioning, biomarkers of cognition, anxiety, and depression

4 weeks

Treatment Details

Interventions

• Happy Older Latinos are Active (HOLA)

Trial Overview The study tests the 'Happy Older Latinos are Active (HOLA)' program to prevent memory loss and decline in mental function among older Latino adults with HIV. It aims to find effective strategies for maintaining cognitive health in this population.

Participant Groups

Group I: HOLA Group Experimental Treatment 1 Intervention

Participants in this group will receive a multicomponent intervention for 16 weeks.

Who Is Running the Clinical Trial?

University of Miami

Lead Sponsor

Trials

976

Recruited

423,000+

National Institute on Minority Health and Health Disparities (NIMHD)

Collaborator

Trials

473

Recruited

1,374,000+

National Institute on Aging (NIA)

Collaborator

Trials

1,841

Recruited

28,150,000+