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Fluoxetine for Obsessive-Compulsive Disorder
Study Summary
This trial will study how well a certain drug works for treating OCD, by looking at brain scans of people before and after taking the drug.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
Media Library
- My family does not have a history of OCD or related disorders.I have used sleep aids or painkillers within 3 days before a scan.You have a history of severe mental illnesses like schizophrenia or bipolar disorder.I am considering and suitable for fluoxetine treatment.I did not improve after taking fluoxetine (40 mg/day) for 12 weeks.I am not on regular psychoactive medication, except for occasional sleep aids.Your baseline score on the Y-BOCS test is 16 or higher.I have severe claustrophobia or back pain that makes MR scans difficult.I haven't taken any mental health medications in the last 8 weeks, except for sleep aids or painkillers.I am an adult willing to participate in a study that aims for diversity in gender, race, and age.I am not taking Coumadin or MAOIs.I have been diagnosed with OCD by a professional.I have never had a major brain injury or serious neurological disease.I am not pregnant, do not plan to become pregnant, and will use birth control during the study.You have struggled with drug or alcohol addiction in the past 6 months.You have metal in your body or any other reason why you can't have an MRI scan.I have had an allergic reaction or bad side effect from fluoxetine or similar medications.
- Group 1: Healthy Controls
- Group 2: OCD Group
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Who has the prerequisites to participate in this clinical experiment?
"This clinical trial is enrolling 120 individuals suffering from Obsessive Compulsive Disorder, aged 18-65. Applicants must satisfy the following criteria: (i) Adults of all genders in a 1:1 ratio with respect to age, handedness and other demographic data; (ii) Signed informed consent approved by Yale's Human Investigations Committee; (iii) Willingness and ability to participate in study procedures including assessments and fMRI scans; (iv) A DSM diagnosis of OCD established via various means; (v) Not currently taking psychoactive medications aside from PRN sleep aids; For women of childbearing potential, not pregnant"
Are there any historical records of trials with Fluoxetine administered at a later time?
"Currently, 15 studies exploring the efficacy of Fluoxetine - delayed treatment are active with two trials in Phase 3. These tests span 20 different locations across America; however, a majority are located in New Haven, Connecticut."
What is the total enrollment count for this scientific investigation?
"Affirmative. On clinicaltrials.gov, it is noted that this study opened for enrollment on October 15th 2019 and has been modified as recently as May 31st 2022 - presently recruiting 120 individuals from a single location."
Are applicants aged 85 or younger admissible to this trial?
"According to the criteria set forth, qualified applicants for this trial must be within 18 and 65 years old. Those younger than 18 or older than 65 have separate clinical trials with 25 and 77 studies respectively."
Has the FDA greenlighted Fluoxetine - delayed treatment?
"Our team at Power assigned Fluoxetine - delayed treatment a score of 1, due to its Phase 1 trial status indicating limited evidence for both safety and efficacy."
Are there any available openings for participants in this clinical research?
"According to the clinicaltrials.gov database, this clinical trial is presently accepting new participants. The entry was created on October 15th 2019 and its most recent update occurred on May 31st 2022."
Does Fluoxetine - delayed treatment often provide aid for what kind of affliction?
"Through Fluoxetine - delayed treatment, medical professionals may be able to provide relief for myoclonus, unipolar depression, and obsessive-compulsive disorder."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
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