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Electrophysiological recordings in participants with intracranially implanted electrodes for Epilepsy

N/A

Waitlist Available

Led By Matthias Stangl

Research Sponsored by University of California, Los Angeles

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adequate visual and auditory acuity to allow neuropsychological testing

Have undergone depth electrode placement for the purpose of epilepsy evaluation/treatment OR have NeuroPace RNS System implanted for epilepsy treatment

Timeline

Screening 3 weeks

Treatment Varies

Follow Up continuous measurement during task performance on day 1 and all subsequent measurement days (up to 14 days per participant)

Awards & highlights

Study Summary

This trialwill explore how the human brain encodes spatial information (location, orientation, movements) of others in social settings. It will use intracranial electrodes to record brain activity, to study how the brain keeps track of other people in the environment.

Who is the study for?

This trial is for individuals aged 18-70 with epilepsy who have had depth electrodes placed or a NeuroPace RNS System implanted for treatment. They must be able to see and hear well enough for neuropsychological tests. People with psychiatric disorders (except nicotine-dependence) or brain damage cannot participate.Check my eligibility

What is being tested?

The study investigates how the human brain tracks spatial information about others' movements. It involves observation tasks and self-navigation tasks, recording deep brain activity in participants with implanted electrodes during these activities.See study design

What are the potential side effects?

Since this trial involves non-invasive observation and navigation tasks, there are minimal expected side effects related to the procedures themselves; however, risks may be associated with the condition of epilepsy and pre-existing implants.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I can see and hear well enough for brain function tests.

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I have had surgery for epilepsy either with depth electrodes or a NeuroPace RNS System.

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I am between 18 and 70 years old.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ continuous measurement during task performance on day 1 and all subsequent measurement days (up to 14 days per participant)

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~continuous measurement during task performance on day 1 and all subsequent measurement days (up to 14 days per participant)

This trial's timeline: 3 weeks for screening, Varies for treatment, and continuous measurement during task performance on day 1 and all subsequent measurement days (up to 14 days per participant) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Firing rate of single neurons

Oscillatory amplitude

Oscillatory frequency

+1 more

Other outcome measures

Eye

Trial Design

1Treatment groups

Experimental Treatment

Group I: Electrophysiological recordings in participants with intracranially implanted electrodesExperimental Treatment2 Interventions

All participants will perform behavioral tasks that test their spatial navigation and memory performance in self-navigation and observation tasks.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor

1,528 Previous Clinical Trials

10,276,837 Total Patients Enrolled

13 Trials studying Epilepsy

880 Patients Enrolled for Epilepsy

Matthias StanglPrincipal InvestigatorUniversity of California, Los Angeles

Media Library

Electrophysiological recordings in participants with intracranially implanted electrodes Clinical Trial Eligibility Overview. Trial Name: NCT05406349 — N/A

Epilepsy Research Study Groups: Electrophysiological recordings in participants with intracranially implanted electrodes

Epilepsy Clinical Trial 2023: Electrophysiological recordings in participants with intracranially implanted electrodes Highlights & Side Effects. Trial Name: NCT05406349 — N/A

Electrophysiological recordings in participants with intracranially implanted electrodes 2023 Treatment Timeline for Medical Study. Trial Name: NCT05406349 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the size of the census for this research endeavor?

"Correct. Information hosted on clinicaltrials.gov confirms that this medical investigation, initially posted on August 6th 2022, is currently recruiting participants. Approximately 105 people need to be recruited across 1 trial site."

Answered by AI

Does this research require any volunteer participants currently?

"Clinicaltrials.gov indicates that this clinical study is currently enrolling participants. The trial was initially uploaded on August 6th 2022 and has been altered most recently on October 31st 2022."

Answered by AI

Is the enrollment criteria for this trial inclusive of individuals over eighty-five years old?

"Eligibility for this medical trial is restricted to participants aged 18-70. There are 19 trials available for underage individuals and 29 experiments open to elderly people above the age of 65."

Answered by AI

What type of individuals is this investigation most suited for?

"Eligibility criteria for this study necessitates that prospective participants must be between 18-70 years of age and have a diagnosis of epilepsy. The research team is looking to enroll approximately 105 patients in total."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Neural Mechanisms of Spatial Representations Beyond the Self

Matthias Stangl, PhD 2022. "Neural Mechanisms of Spatial Representations Beyond the Self". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05406349.