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HP 129Xe MRI for Lung Function Assessment (HpXeMRCal Trial)

Phase 1 & 2

Recruiting

Led By Jason C Woods, Ph.D.

Research Sponsored by Children's Hospital Medical Center, Cincinnati

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Participant must be able to hold their breath for up to 16 seconds

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up day 1

Awards & highlights

HpXeMRCal Trial Summary

This trial will test if HP 129Xe gas MRI can be used to assess regional lung function in adults without lung disease.

Who is the study for?

This trial is for adults who can hold their breath for up to 16 seconds. It's not suitable for those with heart defects, uncontrolled asthma, low oxygen levels without support, or recent respiratory infections. Pregnant individuals and those with MRI-incompatible implants are also excluded.Check my eligibility

What is being tested?

The study tests the effectiveness of using hyperpolarized Xenon (129Xe) gas during an MRI to assess lung function in healthy adults. The aim is to achieve optimal imaging results that could help understand lung health better.See study design

What are the potential side effects?

While the trial involves inhaling a special gas and undergoing an MRI scan, potential side effects may include discomfort from holding one's breath and temporary dizziness or lightheadedness from the hyperpolarized xenon.

HpXeMRCal Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I can hold my breath for up to 16 seconds.

HpXeMRCal Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ day 1

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~day 1

This trial's timeline: 3 weeks for screening, Varies for treatment, and day 1 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Correlation of ventilated volume predictions obtained with 129Xe MRI vs. 1H MRI

HpXeMRCal Trial Design

1Treatment groups

Experimental Treatment

Group I: Hyperpolarized 129 XenonExperimental Treatment2 Interventions

Administration of up to 1 liter doses of Hyperpolarized Xenon gas during MRI to optimize acquisition of images for adults vs. proton MR imaging. These scans, utilizing volunteers for calibration, may be utilized through this study to optimize the scan details.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

MRI

2009

Completed Phase 2

~1370

0 / 1Eligibility criteria met

Find a Location

Logistics

Participation is compensated

You will be compensated for participating in this trial.

Who is running the clinical trial?

Children's Hospital Medical Center, CincinnatiLead Sponsor

815 Previous Clinical Trials

6,531,491 Total Patients Enrolled

1 Trials studying Respiratory Disorders

300 Patients Enrolled for Respiratory Disorders

Jason C Woods, Ph.D.Principal InvestigatorChildren's Hospital Medical Center, Cincinnati

Media Library

Hyperpolarized 129 Xenon Clinical Trial Eligibility Overview. Trial Name: NCT02316379 — Phase 1 & 2

Respiratory Disorders Research Study Groups: Hyperpolarized 129 Xenon

Respiratory Disorders Clinical Trial 2023: Hyperpolarized 129 Xenon Highlights & Side Effects. Trial Name: NCT02316379 — Phase 1 & 2

Hyperpolarized 129 Xenon 2023 Treatment Timeline for Medical Study. Trial Name: NCT02316379 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there any unfilled vacancies for this experiment?

"That is correct, the listing on clinicaltrials.gov shows that this particular trial is seeking volunteers. This specific study was originally posted on February 1st, 2015 with the latest update happening on December 17th, 2020. They are looking for a total of one hundred participants from one medical site."

Answered by AI

Are there other instances of Hyperpolarized 129 Xenon being used in medical research?

"There are 15 ongoing medical studies involving hyperpolarized 129 xenon and 0 of those trials are in phase 3. Many of the clinical trials related to this topic are based in Philadelphia, but there are a total of 21 locations running these kinds of tests."

Answered by AI

How many people can join this trial at most?

"That is correct, the trial is still recruiting patients. The listing on clinicaltrials.gov says that the first posting was on February 1st, 2015 and the most recent update was on December 17th, 2020. They are looking for a total of 100 patients from 1 location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration

2015. "Use of Hyperpolarized 129Xe MR Lung Imaging in Adults for Calibration". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02316379.

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