Memsorb Filter System for Anesthesia Environmental Impact

LF
RN
Overseen ByRuediger Noppens, MD, PhD, FRCPC
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Western University, Canada
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new method for managing carbon dioxide during surgery using a device called Memsorb. Memsorb reduces anesthesia waste and lowers pollution by filtering out carbon dioxide without producing harmful byproducts. The trial compares Memsorb to traditional methods across various surgeries to evaluate its effectiveness. Individuals scheduled for planned, non-emergency surgeries without severe breathing issues may qualify for participation. As an unphased trial, this study allows participants to contribute to innovative research that could lead to more environmentally friendly surgical practices.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What prior data suggests that the Memsorb Filter System is safe for use in anesthesia?

Research has shown that the Memsorb system safely removes CO2 from anesthesia machines without harmful chemicals, avoiding toxic byproducts that some traditional methods produce. The Memsorb employs a special filter, similar to those in heart surgery, to remove CO2 while retaining the anesthetic gas. This approach aims to reduce the amount of anesthetic needed, potentially benefiting both patients and the environment.

In contrast, chemical granulate absorbers (CGAs) currently in use can react with anesthetic gases to create toxic byproducts, which may harm the kidneys and nervous system. Increasing anesthetic gas to dilute these byproducts also raises costs and environmental impact.

Although specific safety studies on Memsorb in humans are not yet available, the technology resembles other safe methods. Its goal to eliminate harmful chemical reactions suggests it could be a safer option. However, always consider joining a clinical trial after consulting healthcare professionals for personalized advice.12345

Why are researchers excited about this trial?

Researchers are excited about the Memsorb Filter System because it offers a way to make anesthesia more environmentally friendly. Unlike traditional chemical CO2 absorbers, Memsorb doesn't rely on chemicals to filter out CO2, which can reduce the environmental impact of anesthesia practices. This new approach could help hospitals lower their carbon footprint without altering existing anesthesia settings, making it a promising alternative to current methods.

What evidence suggests that the Memsorb Filter System is effective for reducing anesthesia environmental impact?

Research has shown that the Memsorb filter system, one of the treatments studied in this trial, effectively removes carbon dioxide (CO2) from anesthesia equipment without using chemical granulate absorbers (CGAs), which are tested in separate trial arms. This means Memsorb avoids creating potentially harmful byproducts that CGAs might produce. Studies have found that Memsorb can reduce the use of anesthetic gases by up to 20%. This not only saves money but also lessens environmental impact since fewer gases are released into the air. Memsorb uses a special membrane technology, similar to that used in heart surgeries, to filter out CO2 while keeping the anesthetic gas in the system. The filter is designed to last at least a year, potentially reducing waste and lowering costs for hospitals.678910

Are You a Good Fit for This Trial?

This trial is for patients undergoing elective surgery, specifically laparoscopic for one part of the study. They should have a physical status classification of ASA I to III, meaning they range from healthy to having some severe disease but not incapacitated. It's not for those with high intracranial pressure, very severe systemic disease (ASA > IV), emergencies, severe respiratory issues like asthma, pregnant individuals or surgeries using regional anesthesia.

Inclusion Criteria

Elective surgical procedure
You have had laparoscopic surgery for the purpose of study aim III.
You are classified as having a low to moderate overall health status.

Exclusion Criteria

You have high pressure inside your brain.
You are pregnant, based on your own report.
Emergency surgery
See 4 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo general anesthesia using either Memsorb or CGA systems during various surgical procedures

Up to 12 hours per procedure
1 visit per surgical procedure

Follow-up

Participants are monitored for safety and effectiveness after anesthesia

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Chemical granulate absorber
  • Memsorb
Trial Overview The trial is testing Memsorb, a new CO2 membrane filter system against traditional chemical granulate absorbers (CGAs) used during anesthesia in surgeries. The goal is to see if Memsorb can effectively remove CO2 and maintain proper ventilation while reducing anesthetic gas use and environmental impact compared to CGAs.
How Is the Trial Designed?
6Treatment groups
Experimental Treatment
Active Control
Group I: Memsorb low-flowExperimental Treatment1 Intervention
Group II: Memsorb laparoscopic surgeryExperimental Treatment1 Intervention
Group III: Memsorb GAExperimental Treatment1 Intervention
Group IV: CGA low flowExperimental Treatment1 Intervention
Group V: CGA laparoscopic surgeryExperimental Treatment1 Intervention
Group VI: CGA GAActive Control1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Western University, Canada

Lead Sponsor

Trials
270
Recruited
62,500+

Published Research Related to This Trial

The low-volume anesthesia machine (Maquet Flow-i C20) delivered approximately 20% less sevoflurane compared to the traditional anesthesia machine (GE Aisys CS2), indicating greater efficiency in volatile anesthetic delivery during surgery.
Using the MQ machine not only reduces anesthetic costs, potentially saving around $239,440 over 10 years, but also significantly lowers CO2 emissions by 201 metric tons, highlighting its environmental benefits.
Environmental and Economic Impact of Using a Higher Efficiency Ventilator and Vaporizer During Surgery Under General Anesthesia: A Randomized Controlled Prospective Cohort.Field, RR., Calderon, MC., Ronilo, SM., et al.[2023]

Citations

Memsorb Filter System for Anesthesia Environmental ImpactThe low-volume anesthesia machine (Maquet Flow-i C20) delivered approximately 20% less sevoflurane compared to the traditional anesthesia machine (GE Aisys CS2) ...
2.memsorb.commemsorb.com/
about memsorb™ | memsorbmemsorb™ is a next-generation CO2 filter for anesthetic circuits that uses membrane technology to separate CO2 from the re-breathing circuit. How it works.
3.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/35103886/
Memsorb™, a novel CO2 removal device part IIMemsorb™ (DMF Medical, Halifax, Canada) is a novel device based upon membrane oxygenator technology designed to eliminate CO2 from exhaled gas ...
Memsorb™, a novel CO2 removal device part ISoda lime-based CO2 absorbents are safe, but not ideal for reasons of ecology, economy, and dust formation. The Memsorb™ is a novel CO2 ...
A New and Innovative Method for CO2 Removal in ...memsorb uses patented advanced medical membrane technology to filter CO2 from anesthetic circuits rather than absorbing via a chemical reaction.
Safe For Low-Flow - CO2 Absorbent TechnologyTraditional granular absorbents are known to degrade volatile anesthetics and produce toxic byproducts, including Compound A, Carbon Monoxide, and Formaldehyde, ...
Environmental and Occupational Considerations of ...The chemical properties and global warming impacts of these gases vary, with atmospheric lifetimes of 1−5 years for sevoflurane, 3−6 years for ...
Anesthetic Gases: Guidelines for Workplace ExposuresThe recommendations of the chemical manufacturer's material safety data sheet (MSDS) that identify exposure reduction techniques for spills and emergencies ...
The Environmental Impact of Using a CO2 Absorber during ...Inhaled anesthetics are actually a form of greenhouse gas that can be destructive to the ozone layer. However, because they are considered ...
Eliminate the risks of granular absorbents during low-flow ...Reduced Environmental Impact. Promotes safe use of reduced fresh gas flow rates; Less absorbent material is used; Lower pH due to low-flow chemistry; Reduction ...
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