This trial is evaluating whether Early Ileostomy Closure will improve 8 secondary outcomes in patients with Cancer of Rectum. Measurement will happen over the course of Starting from restorative proctectomy post-operative day 1 through the course of the study (1 year follow-up).
This trial requires 118 total participants across 2 different treatment groups
This trial involves 2 different treatments. Early Ileostomy Closure is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are not being studied for commercial purposes.
"It is probable that both genetic and environmental factors play an important role in the causation of rectal cancer. Genetic and environmental factors seem to affect the development of advanced disease, but the exact mechanisms involved remain unclear. A prospective study has been started to determine whether screening people with familial adenomatous polyposis or colorectal cancer will reduce further cases. [Power(http://www.withpower." - Anonymous Online Contributor
"Early IT following surgery for lower GI malignancies is associated with better QOL outcomes and less deficiencies compared to delayed IT at 3 months. These data provide further support for a randomized study comparing early versus delayed IT in managing TP in patients undergoing resection for rectal cancer." - Anonymous Online Contributor
"Rectal cancers are most commonly caused by chronic inflammation and infection (such as Human papillomavirus infection), smoking, diet, etc. Prevention includes eliminating these risk factors." - Anonymous Online Contributor
"Early ileostomy closure was associated with significantly fewer hospital stay days and less time off work compared with maintenance of a stoma. The findings demonstrate the benefit of early closure of ileostomies." - Anonymous Online Contributor
"Androgen insensitivity syndrome is an important risk factor for development of cancer of the rectum. This emphasizes the need for screening for androgen insensitivity syndrome in individuals with rectal cancer, especially in males." - Anonymous Online Contributor
"The majority of patients diagnosed with cancer of rectum are older than 60 years, female, white, and have low income. The mean time between first symptom and diagnosis was 30 months; almost half were concerned about being unable to afford care. Based on our results, we believe that early detection through screening should be continued as an important part of the management of colorectal neoplasms." - Anonymous Online Contributor
"For the first time since 1990, there has been no change in the number of cases of cancer of rectum detected annually in the United States. This finding suggests that current screening practices are adequate and that further examination of the population is unnecessary." - Anonymous Online Contributor
"The recent advances in surgical techniques for ileostomy closure have allowed for an appreciation of the physiological mechanisms involved in healing of ileostomies. As a result, it is possible to formulate a set of guidelines for management of ileostomies." - Anonymous Online Contributor
"Early ileostomy closure reduces the length of stay in hospital without adversely affecting overall length of stay, time interval of discharge, or readmission rates. Despite this finding, there was no decrease in postoperative ileus or wound infection despite an increased number of patients requiring prophylactic antibiotics. Early ileostomy closure may facilitate early ambulation in patients undergoing abdominoperineal resection for cancer of the rectum." - Anonymous Online Contributor
"The occurrence of rectal cancer is not uncommon; however, the incidence of locally advanced rectal cancer seems to be lower than that reported from other regions of the world. More extensive studies are needed to determine if this difference is real or due to bias in reporting." - Anonymous Online Contributor
"Results from a recent paper of this survey suggest that patients who do not have a strong desire to receive a curative treatment should not participate in a clinical trial of CRC due to the high cost and the risk of potential side effects." - Anonymous Online Contributor