Acoustic Angiography for Breast Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial explores a new imaging technique called Acoustic Angiography to determine if it can better detect breast and thyroid lesions. It includes three groups: one for breast patients, another for thyroid patients, and a group of healthy volunteers to refine the imaging process. The goal is to assess whether Acoustic Angiography combined with ultrasound can improve biopsy accuracy. Women with breast lesions or individuals with thyroid lesions already scheduled for a biopsy may be suitable for this study. As a Phase 2 trial, the research focuses on evaluating the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to significant advancements in medical imaging.
Do I need to stop my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. However, if you have active cardiac disease or are critically ill, you may not be eligible to participate.
What prior data suggests that acoustic angiography is safe for breast and thyroid imaging?
Research has shown that acoustic angiography, a new method for imaging blood vessels using sound waves, has been tested for both breast and thyroid imaging. Previous studies report that this technology is generally well-tolerated, with no major safety issues.
For breast imaging, studies have found that it provides clear images without using radiation, making it safer than some traditional methods that do use radiation.
In thyroid imaging, acoustic angiography also appears safe. Although it's a new technique, research has not identified any serious side effects.
Being in a Phase 2 trial indicates the treatment has already passed initial safety tests. While monitoring for new information remains important, current studies suggest it is safe.12345Why are researchers excited about this trial?
Researchers are excited about acoustic angiography for breast cancer because it offers a non-invasive imaging technique that could provide clearer, more detailed pictures of blood vessels in breast tissue. Unlike traditional imaging methods, like mammograms or MRIs, acoustic angiography uses sound waves to create high-resolution images, potentially improving the accuracy of breast cancer diagnoses. This technique could help doctors detect tumors earlier and tailor treatments more precisely, reducing unnecessary biopsies and improving patient outcomes.
What evidence suggests that acoustic angiography is effective for breast and thyroid imaging?
Research has shown that acoustic angiography, a new imaging method, could be promising for detecting breast cancer. This technique provides detailed pictures of blood vessels in breast tissue. In this trial, participants in the Breast Imaging Cohort will undergo acoustic angiography to assess its effectiveness compared to traditional methods like mammograms, which can sometimes miss tumors. For thyroid issues, participants in the Thyroid Imaging Cohort will be evaluated to see if acoustic angiography helps spot unusual growths more clearly. Early findings suggest it could improve detection without using radiation, a common concern with other imaging methods.15678
Who Is on the Research Team?
Yueh Lee, MD, PhD
Principal Investigator
University of North Carolina, Chapel Hill
Are You a Good Fit for This Trial?
This trial is for adults who can consent and are scheduled for certain breast or thyroid biopsies or surgeries at UNC. Women must not be pregnant. Excluded are those in critical condition, with severe heart issues, known allergies to Definity®, men, and anyone with larger or deeper lesions than specified.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Imaging Optimization
Healthy volunteers undergo imaging to optimize parameters for acoustic angiography
Diagnostic Imaging
Participants with breast and thyroid lesions undergo acoustic angiography and b-mode ultrasound prior to scheduled biopsy
Follow-up
Participants are monitored for safety and effectiveness after imaging procedures
What Are the Treatments Tested in This Trial?
Interventions
- Acoustic Angiography
Find a Clinic Near You
Who Is Running the Clinical Trial?
UNC Lineberger Comprehensive Cancer Center
Lead Sponsor
National Cancer Institute (NCI)
Collaborator