Radiation Therapy Techniques for Lung Cancer
Trial Summary
What is the purpose of this trial?
This is a pilot study designed to to provide data and experience comparing two different techniques of breath hold SBRT treatments. The first technique will include SGRT, but with the assistance of implanted fiducials. Subjects will be treated with a breath hold technique utilizing SGRT, but will also be imaged during treatment with fiducial match. The second technique will utilize SGRT for breath hold treatments without the assistance of implanted fiducials/continuous imaging.
Will I have to stop taking my current medications?
If you are receiving systemic chemotherapy or other systemic agents, you must stop taking them during the SBRT treatments.
What data supports the effectiveness of the treatment Breath Hold SBRT, SGRT for lung cancer?
Research shows that using breath-hold techniques like deep inspiration breath-hold (DIBH) in lung cancer treatment helps reduce tumor movement during radiation, which can improve the accuracy of targeting the cancer. Studies also indicate that surface-guided radiation therapy (SGRT) can enhance the precision of treatment delivery by monitoring the patient's position, potentially leading to better outcomes.12345
Is radiation therapy using techniques like Breath Hold SBRT and SGRT safe for lung cancer patients?
Radiation therapy techniques like Breath Hold SBRT and SGRT have been shown to be generally safe for lung cancer patients, with studies indicating high patient compliance and reduced doses to critical organs like the heart and lungs. However, tumors in ultra-central locations may require special safety considerations.14567
How is the Breath Hold SBRT treatment for lung cancer different from other treatments?
Breath Hold SBRT for lung cancer is unique because it uses a technique called deep inspiration breath-hold (DIBH) to minimize tumor movement during radiation therapy, which helps in delivering precise doses to the tumor while reducing exposure to surrounding healthy tissues. This approach can lead to better targeting of the tumor and potentially fewer side effects compared to traditional methods that do not manage breathing motion as effectively.14568
Research Team
John Heinzerling, MD
Principal Investigator
Wake Forest University Health Sciences
Eligibility Criteria
This trial is for adults over 18 with certain types of lung cancer or tumors that move when they breathe. They must be able to follow the study plan and use effective birth control if needed. People can't join if they've had chest radiation before, have an active lung infection or pneumonitis, or were treated for pneumonitis within the last 15 days.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive SBRT treatment with or without fiducials for breath hold techniques
Follow-up
Participants are monitored for safety and effectiveness after treatment
Long-term follow-up
Participants are monitored for overall survival and local control of treated tumors
Treatment Details
Interventions
- Breath Hold SBRT
- SGRT
Find a Clinic Near You
Who Is Running the Clinical Trial?
Atrium Health
Lead Sponsor
Wake Forest University Health Sciences
Lead Sponsor
Atrium Health Levine Cancer Institute
Collaborator