240 Participants Needed

CMR Imaging Techniques for Heart Disease

(Myomapping Trial)

TL
FB
MG
VG
JR
Overseen ByJacob Rowe, BA
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Medical University of South Carolina
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 6 JurisdictionsThis treatment is already approved in other countries

Trial Summary

What is the purpose of this trial?

The overall goal of this project is to evaluate the clinical potential of fast quantitative myocardial tissue characterization using recently emerged Cardiac Magnetic Resonance Imaging (CMR) techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases, such as ischemic heart disease, cardiomyopathies, and myocarditis.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Cardiac Magnetic Resonance (CMR) imaging techniques for heart disease?

CMR imaging is a powerful tool for diagnosing and monitoring heart diseases because it provides detailed images of the heart without using radiation. It is especially useful for evaluating conditions like coronary artery disease and cardiomyopathies, offering important information that other imaging methods cannot provide.12345

Is CMR imaging safe for humans?

CMR imaging is generally considered safe as it is non-invasive and does not use radiation. However, there are some safety considerations, such as the presence of metal or electronic devices in the body, and potential discomfort from claustrophobia or the need to hold your breath during the procedure.36789

How does CMR imaging differ from other treatments for heart disease?

CMR imaging is unique because it provides a noninvasive way to assess the heart's structure and function, offering detailed tissue characterization and the ability to evaluate heart disease without the need for invasive procedures. Unlike other treatments, it can provide comprehensive diagnostic and prognostic information, making it a valuable tool for monitoring heart disease over time.1241011

Research Team

JU

Joseph U. Schoepf, MD

Principal Investigator

Medical University of South Carolina

Eligibility Criteria

This trial is for adults aged 18-90 with suspected or diagnosed heart conditions like ischemic heart disease, hypertrophic cardiomyopathy, infiltrative cardiomyopathy, or myocarditis. They must be referred for a CMR scan and can't participate if they have metal implants, acute psychiatric disorders, substance abuse issues, allergies to MRI contrast agents, are in an unstable condition or won't follow the study rules.

Inclusion Criteria

I have or might have a heart condition such as blocked arteries, thickened heart muscle, a disease causing heart tissue buildup, or inflammation of the heart muscle.
I am between 18 and 90 years old.
You must have been referred for a needed heart imaging test.

Exclusion Criteria

Subject has previously entered this study.
Subject has an allergy against MRI contrast agents.
Subject is in acute unstable condition.
See 4 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Participants undergo fast quantitative myocardial tissue characterization using Cardiac Magnetic Resonance Imaging (CMR) techniques

1 day
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging

4 weeks

Treatment Details

Interventions

  • Cardiac Magnetic Resonance (CMR) imaging techniques
Trial OverviewThe trial is testing advanced Cardiac Magnetic Resonance Imaging (CMR) techniques to better diagnose and monitor various heart diseases. It aims to see how well these new fast quantitative imaging methods work compared to traditional ones.
Participant Groups
1Treatment groups
Experimental Treatment
Group I: Additional 5 minute research MR scan of heart.Experimental Treatment1 Intervention
The purpose of this is to evaluate new, faster MR scans

Find a Clinic Near You

Who Is Running the Clinical Trial?

Medical University of South Carolina

Lead Sponsor

Trials
994
Recruited
7,408,000+

Findings from Research

Cardiac magnetic resonance (CMR) imaging is a valuable tool for assessing various heart conditions, particularly coronary artery disease and heart failure, which are significant health issues globally.
CMR offers unique tissue characterization capabilities that other imaging methods lack, providing critical diagnostic and prognostic insights into different heart diseases.
Advances in Cardiovascular MRI for Diagnostics: Applications in Coronary Artery Disease and Cardiomyopathies.Salerno, M., Kramer, CM.[2021]
Cardiac magnetic resonance (CMR) imaging is a highly effective noninvasive technique that has significantly improved in resolution and speed over the last two decades, making it valuable for diagnosing and monitoring cardiovascular diseases.
CMR can assess various aspects of heart health, including morphology, function, perfusion, and tissue characterization, which supports its use in both diagnosis and follow-up after treatment.
Cardiac MRI: technical basis.Russo, V., Lovato, L., Ligabue, G.[2020]
Cardiovascular magnetic resonance (CMR) is a non-invasive imaging technique that effectively assesses various aspects of heart health, including morphology, function, and blood flow, making it suitable for monitoring treatment effects and disease progression without exposing patients to radiation.
CMR faces unique challenges due to heart and lung movement, requiring advanced techniques like cardiac and respiratory gating to minimize motion artifacts, which is crucial for accurate clinical assessments.
Introduction to Cardiovascular Magnetic Resonance: Technical Principles and Clinical Applications.Tseng, WY., Su, MY., Tseng, YH.[2020]

References

Advances in Cardiovascular MRI for Diagnostics: Applications in Coronary Artery Disease and Cardiomyopathies. [2021]
Cardiac MRI: technical basis. [2020]
3.China (Republic : 1949- )pubmed.ncbi.nlm.nih.gov
Introduction to Cardiovascular Magnetic Resonance: Technical Principles and Clinical Applications. [2020]
The Multi-Faceted Utility of Cardiovascular Magnetic Resonance Imaging: Editorial on Special Issue "Advances in Cardiovascular Magnetic Resonance". [2023]
Appropriate use criteria for cardiovascular MRI: SIC - SIRM position paper Part 2 (myocarditis, pericardial disease, cardiomyopathies and valvular heart disease). [2023]
Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease. [2018]
Risk factors for adverse events during cardiovascular magnetic resonance in congenital heart disease. [2013]
Current variables, definitions and endpoints of the European cardiovascular magnetic resonance registry. [2021]
Cardiovascular magnetic resonance: What clinicians should know about safety and contraindications. [2021]
10.United Statespubmed.ncbi.nlm.nih.gov
Current state of the art cardiovascular MR imaging techniques for assessment of ischemic heart disease. [2022]
Cardiac magnetic resonance imaging: current status and future directions. [2013]