CMR Imaging Techniques for Heart Disease

(Myomapping Trial)

Overseen By Jacob Rowe, BA

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: Medical University of South Carolina

Disqualifiers: Implanted device, Acute psychiatric, Substance abuse, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Approved in 6 Jurisdictions This treatment is already approved in other countries

Compensation: Varies

Number of Visits: 1

240 Participants Needed

Trial Summary

What is the purpose of this trial?

The overall goal of this project is to evaluate the clinical potential of fast quantitative myocardial tissue characterization using recently emerged Cardiac Magnetic Resonance Imaging (CMR) techniques to aid the diagnosis, treatment, and follow up of patients with myocardial diseases, such as ischemic heart disease, cardiomyopathies, and myocarditis.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Cardiac Magnetic Resonance (CMR) imaging techniques for heart disease?

CMR imaging is a powerful tool for diagnosing and monitoring heart diseases because it provides detailed images of the heart without using radiation. It is especially useful for evaluating conditions like coronary artery disease and cardiomyopathies, offering important information that other imaging methods cannot provide. ^{1 2 3 4 5}

Is CMR imaging safe for humans?

CMR imaging is generally considered safe as it is non-invasive and does not use radiation. However, there are some safety considerations, such as the presence of metal or electronic devices in the body, and potential discomfort from claustrophobia or the need to hold your breath during the procedure. ^{3 6 7 8 9}

How does CMR imaging differ from other treatments for heart disease?

CMR imaging is unique because it provides a noninvasive way to assess the heart's structure and function, offering detailed tissue characterization and the ability to evaluate heart disease without the need for invasive procedures. Unlike other treatments, it can provide comprehensive diagnostic and prognostic information, making it a valuable tool for monitoring heart disease over time. ^{1 2 4 10 11}

Research Team

Joseph U. Schoepf, MD

Principal Investigator

Medical University of South Carolina

Eligibility Criteria

This trial is for adults aged 18-90 with suspected or diagnosed heart conditions like ischemic heart disease, hypertrophic cardiomyopathy, infiltrative cardiomyopathy, or myocarditis. They must be referred for a CMR scan and can't participate if they have metal implants, acute psychiatric disorders, substance abuse issues, allergies to MRI contrast agents, are in an unstable condition or won't follow the study rules.

Inclusion Criteria

I have or might have a heart condition such as blocked arteries, thickened heart muscle, a disease causing heart tissue buildup, or inflammation of the heart muscle.

I am between 18 and 90 years old.

You must have been referred for a needed heart imaging test.

Exclusion Criteria

Subject has previously entered this study.

Subject has an allergy against MRI contrast agents.

Subject is in acute unstable condition.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Imaging

Participants undergo fast quantitative myocardial tissue characterization using Cardiac Magnetic Resonance Imaging (CMR) techniques

1 day

1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after imaging

4 weeks

Treatment Details

Interventions

• Cardiac Magnetic Resonance (CMR) imaging techniques

Trial Overview The trial is testing advanced Cardiac Magnetic Resonance Imaging (CMR) techniques to better diagnose and monitor various heart diseases. It aims to see how well these new fast quantitative imaging methods work compared to traditional ones.

Participant Groups

Group I: Additional 5 minute research MR scan of heart. Experimental Treatment 1 Intervention

The purpose of this is to evaluate new, faster MR scans

Who Is Running the Clinical Trial?

Medical University of South Carolina

Lead Sponsor

Trials

994

Recruited

7,408,000+

Findings from Research

Cardiac magnetic resonance (CMR) imaging is a valuable tool for assessing various heart conditions, particularly coronary artery disease and heart failure, which are significant health issues globally.

CMR offers unique tissue characterization capabilities that other imaging methods lack, providing critical diagnostic and prognostic insights into different heart diseases.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Advances in Cardiovascular MRI for Diagnostics: Applications in Coronary Artery Disease and Cardiomyopathies. Salerno, M., Kramer, CM.[2021]

Cardiac magnetic resonance (CMR) imaging is a highly effective noninvasive technique that has significantly improved in resolution and speed over the last two decades, making it valuable for diagnosing and monitoring cardiovascular diseases.

CMR can assess various aspects of heart health, including morphology, function, perfusion, and tissue characterization, which supports its use in both diagnosis and follow-up after treatment.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiac MRI: technical basis. Russo, V., Lovato, L., Ligabue, G.[2020]

Cardiovascular magnetic resonance (CMR) is a non-invasive imaging technique that effectively assesses various aspects of heart health, including morphology, function, and blood flow, making it suitable for monitoring treatment effects and disease progression without exposing patients to radiation.

CMR faces unique challenges due to heart and lung movement, requiring advanced techniques like cardiac and respiratory gating to minimize motion artifacts, which is crucial for accurate clinical assessments.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Introduction to Cardiovascular Magnetic Resonance: Technical Principles and Clinical Applications. Tseng, WY., Su, MY., Tseng, YH.[2020]

Cardiovascular magnetic resonance (CMR) imaging is a powerful and flexible technique for assessing various cardiovascular diseases, highlighting its growing importance in clinical practice.

CMR provides detailed insights into heart structure and function, aiding in the diagnosis and management of cardiovascular conditions, although specific study details and outcomes were not provided in the abstract.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

The Multi-Faceted Utility of Cardiovascular Magnetic Resonance Imaging: Editorial on Special Issue "Advances in Cardiovascular Magnetic Resonance". Lu, M., Sirajuddin, A.[2023]

Cardiovascular magnetic resonance (CMR) is recognized as a highly accurate diagnostic tool for assessing various cardiac diseases, providing significant additional diagnostic and prognostic information in clinical settings.

A collaborative effort by experts from the Italian Society of Cardiology and the Italian Society of Radiology aims to enhance the use of CMR in clinical practice, focusing on conditions like myocarditis, pericardial disease, cardiomyopathies, and valvular heart disease.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Appropriate use criteria for cardiovascular MRI: SIC - SIRM position paper Part 2 (myocarditis, pericardial disease, cardiomyopathies and valvular heart disease). Francone, M., Aquaro, GD., Barison, A., et al.[2023]

Cardiovascular magnetic resonance (CMR) is a safe, non-invasive imaging technique that provides detailed information about heart function and tissue characteristics without using ionizing radiation.

CMR has become increasingly important in clinical practice, particularly for assessing ischemic cardiomyopathy, highlighting its efficacy in diagnosing and managing heart conditions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease. Baritussio, A., Scatteia, A., Bucciarelli-Ducci, C.[2018]

In a study of 1334 cardiovascular magnetic resonance (CMR) procedures for patients with congenital heart disease, the overall incidence of adverse events (AEs) was low at 1.6%, with most being minor in severity.

The use of general anesthesia and the status of being an inpatient were identified as independent risk factors for experiencing AEs, particularly in the most critically ill patients, highlighting the need for careful monitoring in these cases.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Risk factors for adverse events during cardiovascular magnetic resonance in congenital heart disease. Dorfman, AL., Odegard, KC., Powell, AJ., et al.[2013]

The EuroCMR Registry aims to evaluate the clinical utility of cardiovascular magnetic resonance (CMR) imaging, focusing on image quality, safety, and its impact on patient management across multiple European centers.

This registry will also track patients with suspected coronary artery disease and hypertrophic cardiomyopathy over 12 months to gather important prognostic data, enhancing our understanding of CMR's effectiveness in these conditions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Current variables, definitions and endpoints of the European cardiovascular magnetic resonance registry. Wagner, A., Bruder, O., Schneider, S., et al.[2021]

Cardiovascular magnetic resonance (MR) is a safe, non-invasive imaging technique that is the gold standard for assessing heart anatomy and function, but it is important to understand the safety and contraindications of various metal and electronic devices in patients undergoing MR.

The review highlights potential factors affecting image quality and patient comfort, such as arrhythmias and claustrophobia, and discusses the safety and side effects of gadolinium-based contrast agents used in MR imaging.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiovascular magnetic resonance: What clinicians should know about safety and contraindications. Barison, A., Baritussio, A., Cipriani, A., et al.[2021]

Cardiac magnetic resonance (CMR) imaging is becoming a key tool for evaluating ischemic heart disease due to its ability to produce high-quality images in various orientations and its advanced techniques for assessing heart structure and function.

Recent advancements in CMR hardware and software have led to improved image quality and the development of quantitative techniques, enhancing the assessment of cardiac function, myocardial perfusion, and tissue characterization.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Current state of the art cardiovascular MR imaging techniques for assessment of ischemic heart disease. François, CJ.[2022]

Cardiac MRI (CMR) is a powerful tool that not only evaluates heart function and structure but also assesses diastolic function, coronary plaque, and myocardial oxygen levels, enhancing its diagnostic capabilities.

Recent technological advancements, including improved imaging systems and techniques like T1 mapping, are expected to broaden the clinical applications of CMR, making it more effective in diagnosing and managing heart conditions.

NCBI (Pubmed)

pubmed.ncbi.nlm.nih.gov

Cardiac magnetic resonance imaging: current status and future directions. Cannan, C., Friedrich, MG.[2013]

References

1. England pubmed.ncbi.nlm.nih.gov

Advances in Cardiovascular MRI for Diagnostics: Applications in Coronary Artery Disease and Cardiomyopathies. [2021]

2. Italy pubmed.ncbi.nlm.nih.gov

Cardiac MRI: technical basis. [2020]

3. China (Republic : 1949- ) pubmed.ncbi.nlm.nih.gov

Introduction to Cardiovascular Magnetic Resonance: Technical Principles and Clinical Applications. [2020]

4. Switzerland pubmed.ncbi.nlm.nih.gov

The Multi-Faceted Utility of Cardiovascular Magnetic Resonance Imaging: Editorial on Special Issue "Advances in Cardiovascular Magnetic Resonance". [2023]

5. United States pubmed.ncbi.nlm.nih.gov

Appropriate use criteria for cardiovascular MRI: SIC - SIRM position paper Part 2 (myocarditis, pericardial disease, cardiomyopathies and valvular heart disease). [2023]

6. United States pubmed.ncbi.nlm.nih.gov

Role of cardiovascular magnetic resonance in acute and chronic ischemic heart disease. [2018]

7. England pubmed.ncbi.nlm.nih.gov

Risk factors for adverse events during cardiovascular magnetic resonance in congenital heart disease. [2013]

8. England pubmed.ncbi.nlm.nih.gov

Current variables, definitions and endpoints of the European cardiovascular magnetic resonance registry. [2021]

9. Netherlands pubmed.ncbi.nlm.nih.gov

Cardiovascular magnetic resonance: What clinicians should know about safety and contraindications. [2021]

10. United States pubmed.ncbi.nlm.nih.gov

Current state of the art cardiovascular MR imaging techniques for assessment of ischemic heart disease. [2022]

11. England pubmed.ncbi.nlm.nih.gov

Cardiac magnetic resonance imaging: current status and future directions. [2013]