In the first year following heart transplantation, it is possible for the recipient to experience serious cardiotoxicity. Although very common in heart transplant recipients, severe cardiotoxicity has a low incidence of death. Patients may be harmed by cardiotoxicity while still in a stable heart failure state.
A comprehensive approach in evaluating drug-induced cardiotoxicity has been described using RIFLE criteria. Clinical use of the RIFLE criteria has not yet been validated. However, these criteria are helpful to identify patients whose cardiac complications may be of clinical importance.
Cardiotoxicity is the common adverse effect in patients using mitotane derivatives. The cardiotoxicity of these agents may be secondary, as mitotane derivatives may cause the myelosuppressants to cause cardiovascular side effects.
The study shows that the curative therapy is well tolerated. The number of patients who are capable of the curative therapy with a very low incidence of cardiotoxicity is significantly higher compared with the number of patients who have cardiotoxicity. With curative therapy, the risk of new heart failure rises, but the incidence is lower than that in patients who develop cardiotoxicity. No difference was noted between the treatment group and control group. summary: Data from a recent study describes the results of a randomized study of patients with early stage of breast cancer who received or did not receive cardiotoxicity curative therapy.
Cardiotoxicity is very commonly treated by reducing the blood lipid level, or more specifically, by antihyperlipidemic drug. It is important to administer the required dose as it may result in adverse effects in patients if not carefully managed. Also, it is very important to check coronary artery test to detect coronary artery disease in patients with hyperlipidemia. Cardiac rehabilitation could also be beneficial. Appropriate treatment to prevent cardiac dysfunction can be performed by taking the history of each patient to assess their cardiovascular status. Moreover, cardiac surgery should be considered in patients with severe cardiac injuries.
A majority of patients with a history of or signs of cardiotoxicity will have a normal EF obtained 3 or more months after surgery. One in five will have abnormal cardiac function. Serial measurements of EF after surgery are useful in determining postoperative prognosis. If patients have a history of ventricular dysfunction or cardiopulmonary bypass, caution is warranted in initiating medical or surgical management. A low EF in a preoperative setting does not necessarily predict a poor postoperative outcome.
About 1.3 million Americans will experience at least one ischemic or nonischemic event in the years ahead, most of which will occur in persons aged 45 years or older. The proportion of the population thought to be affected by CAD increases with age, but is not very prevalent.
The study concludes that heart failure is usually caused by myocardial ischemia that causes abnormal electrical activity in the heart that is responsible for a high left ventricular filling pressure. The result of an abnormal electrical activity in the heart is coronary artery spasm and coronary artery dilatation, which occurs after the onset of heart failure. If patients with this clinical condition do not receive proper medical treatment, they can go on to develop congestive heart failure from a severe deterioration in cardiac function. For that reason, it is crucial to treat patients with hypertension before the onset of heart failure. The main drugs that can prevent heart failure are ACE-inhibitors and angiotensin receptor drugs.
In this pilot study, [1-13c]pyruvate appears to be safe for people, and shows promise in the evaluation and imaging of certain cancers. Further studies are warranted to show its usefulness in evaluating cancer for metastasis and for treatment response.
The use of 13C-pyruvate PET/MRI with mri imaging enables the early assessment of metabolic activity of diseased muscles. This method can be applied as an early evaluation tool for myositis of skeletal muscles.
Most patients without previous cardiac disease and/or with no pre-existing cardiac damage and who receive [chemotherapy including bleomycin] will develop some degree of cardiotoxicity. In contrast, patients with some prior cardiac damage as well as with patients who receive bleomycin but also with [chemotherapy including bleomycin) have a much lower chance of developing cardiotoxicity. The use of bleomycin and [chemotherapy including bleomycin could potentially increase cardiotoxicity when combined with prior cardiac damage. It is recommended that the physician assess whether a patient has prior cardiac damage using a score.
While some side effects occurred more commonly in patients with [1-13c]pyruvate compared to the control MRI, others occurred more frequently in the control MRI compared to the mri MRI. These side effects include: diarrhea, nausea, abdominal pain, nausea, vomiting, nausea, and anorexia.