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Brain Glymphatic Imaging for Parkinson’s Disease

Q: Can patients who take this medication also enroll in the clinical trial?

Eligible participants for this clinical trial must have a diagnosis of <a href="https://www.withpower.com/clinical-trials/parkinson-disease">parkinson disease</a>, be between the ages of 55 and 80. There are approximately 140 spots available in total.

Q: Are applicants of this study required to be over the age of 20 years old?

This particular clinical trial is only for patients aged 55 to 80. Out of the 545 total trials, 28 are for people under 18 and 517 are for people 65 and older.

Q: Are you familiar with any prior research using [11C]-PIB?

There are 4 ongoing investigations utilising [11C]-PIB. 0 of those studies have progressed to Phase 3 clinical trials. The majority of the research is based in Nashville, although there are 5 total locations running these sorts of tests.

Q: Are there any available slots for this clinical trial?

The study, which is looking for participants, was posted on clinicaltrials.gov on 4/15/2020 and was last edited on 4/28/2022.

Q: What is the maximum amount of people who can partake in this research?

That is correct. The clinicaltrials.gov website has information indicating that this study, which was initially posted on 4/15/2020, is still recruiting patients. The trial is looking for a total of 140 participants at 1 location.

Phase < 1

Recruiting

Led By Manus J Donahue, Ph.D.

Research Sponsored by Vanderbilt University Medical Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosis of Parkinson's Disease or controls

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, under anesthesia

Awards & highlights

Study Summary

This trial is looking at whether or not a central nervous system lymphatic drainage system exists in humans, and if it does, whether it could help with conditions like stroke, multiple sclerosis, Parkinson's disease, and Alzheimer's disease related dementia.

Who is the study for?

This trial is for individuals diagnosed with Parkinson's Disease or healthy controls willing to undergo PET and MRI imaging. It excludes those who have used stimulants recently, have unstable diabetes, a history of stroke, claustrophobia, prior chemotherapy for cancer treatment, traumatic brain injury, or any unstable medical condition.Check my eligibility

What is being tested?

[11C]-PIB is being tested as part of an effort to improve imaging methods that can detect issues in the brain's lymphatic drainage system. This could be important for understanding and treating conditions like Parkinson's disease and Alzheimer's related dementia.See study design

What are the potential side effects?

The side effects are not explicitly listed here but generally include risks associated with PET and MRI scans such as discomfort from lying still during the scan or allergic reactions to contrast agents if used.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Select...

I have been diagnosed with Parkinson's Disease.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline, under anesthesia

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline, under anesthesia

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, under anesthesia for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Pulmonary Diffusing Capacity

Trial Design

1Treatment groups

Experimental Treatment

Group I: Parkinson's Disease participants with MCIExperimental Treatment1 Intervention

Patient volunteers will also undergo a C-11 PiB PET scan. This procedure utilizes a common radiotracer that is used routinely in clinical PET scans and will be purchased here from PETNET and certified for human use. All PET scans will be performed by a certified PET technologist at the Vanderbilt University Institute of Imaging Science.

0 / 1Eligibility criteria met

Find a Location

Who is running the clinical trial?

Vanderbilt University Medical CenterLead Sponsor

857 Previous Clinical Trials

672,053 Total Patients Enrolled

Manus J Donahue, Ph.D.Principal InvestigatorVanderbilt University Medical Center

Media Library

[11C]-PIB Clinical Trial Eligibility Overview. Trial Name: NCT04768101 — Phase < 1

[11C]-PIB 2023 Treatment Timeline for Medical Study. Trial Name: NCT04768101 — Phase < 1

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can patients who take this medication also enroll in the clinical trial?

"Eligible participants for this clinical trial must have a diagnosis of parkinson disease, be between the ages of 55 and 80. There are approximately 140 spots available in total."

Answered by AI

Are applicants of this study required to be over the age of 20 years old?

"This particular clinical trial is only for patients aged 55 to 80. Out of the 545 total trials, 28 are for people under 18 and 517 are for people 65 and older."

Answered by AI

Are you familiar with any prior research using [11C]-PIB?

"There are 4 ongoing investigations utilising [11C]-PIB. 0 of those studies have progressed to Phase 3 clinical trials. The majority of the research is based in Nashville, although there are 5 total locations running these sorts of tests."

Answered by AI

Are there any available slots for this clinical trial?

"The study, which is looking for participants, was posted on clinicaltrials.gov on 4/15/2020 and was last edited on 4/28/2022."

Answered by AI

What is the maximum amount of people who can partake in this research?

"That is correct. The clinicaltrials.gov website has information indicating that this study, which was initially posted on 4/15/2020, is still recruiting patients. The trial is looking for a total of 140 participants at 1 location."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Quantitative Imaging of Brain Glymphatic Function in Humans

Manus Donahue 2020. "Quantitative Imaging of Brain Glymphatic Function in Humans". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04768101.

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