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PET/MRI Brain Imaging for Alzheimer's Disease (PiB ADC Trial)
Phase 2
Recruiting
Led By Jonathan McConathy, MD
Research Sponsored by University of Alabama at Birmingham
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights
PiB ADC Trial Summary
This trial will look at how a certain protein is distributed in the brains of those with Alzheimer's, which may help to explain why the disease affects some people more than others.
Who is the study for?
This trial is for participants already enrolled in the UAB Alzheimer's Disease Center study. It's focused on those who can undergo PET/MRI scans and do not have severe dementia that would prevent participation. Women of childbearing potential must test negative for pregnancy.Check my eligibility
What is being tested?
The study aims to measure amyloid deposits in the brain using a PET tracer called [C-11]PiB. It will explore how race and vascular risk factors interact with these amyloid levels and cognitive status.See study design
What are the potential side effects?
Since this is an imaging study, side effects are minimal but may include discomfort from lying still during scanning, reactions to contrast agents used (if any), or claustrophobia inside the scanner.
PiB ADC Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
Amyloidosis
PiB ADC Trial Design
1Treatment groups
Experimental Treatment
Group I: [C-11]PiB-PET/MRIExperimental Treatment1 Intervention
All participants in this study will undergo an amyloid-PET imaging using the tracer [C-11]PiB with a simultaneous PET/MRI system. The [C-11]PiB dosage is 300-670 MBq (8 - 18 mCi) given intravenously, and the PET/MRI imaging time is approximately 60 min.
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Who is running the clinical trial?
University of Alabama at BirminghamLead Sponsor
1,590 Previous Clinical Trials
2,281,194 Total Patients Enrolled
Jonathan McConathy, MDPrincipal InvestigatorUniversity of Alabama at Birmingham
2 Previous Clinical Trials
225 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- You are a student in the UAB-ADC study.I am not pregnant or have been menopausal for over a year or am surgically sterilized.
Research Study Groups:
This trial has the following groups:- Group 1: [C-11]PiB-PET/MRI
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
How many individuals have registered to participate in this research project?
"Affirmative. The clinical trial is currently recruiting participants, as indicated by information on the website of clinicaltrials.gov. This study was first registered on April 20th 2018 and subsequently updated on June 7th 2022; it hopes to enrol 160 individuals from one site."
Answered by AI
Has the [C-11]PiB-PET/MRI combination been endorsed by the FDA?
"The safety of [C-11]PiB-PET/MRI is judged to be a 2 given its Phase 2 status. This signifies that the medication has undergone multiple rounds of assessment for its security, but there is still no evidence demonstrating efficacy."
Answered by AI
Is this experiment currently seeking participants?
"Confirmed, clinicaltrials.gov provides evidence that this trial is currently recruiting individuals and has been updated since its initial post on April 20th 2018."
Answered by AI
Who else is applying?
What site did they apply to?
University of Alabama at Birmingham Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
1
Why did patients apply to this trial?
I want to be part of the solution to this devastating disease.
PatientReceived no prior treatments
What questions have other patients asked about this trial?
How long do the screenings take?
PatientReceived no prior treatments
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