Your session is about to expire
← Back to Search
Sirolimus for Brain Health
Study Summary
This trial will test if a drug can improve blood flow to the brain in people with and without a genetic predisposition to Alzheimer's disease.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Side effects data
From 2008 Phase 4 trial • 293 Patients • NCT00118742Trial Design
Find a Location
Logistics
Participation is compensated
You will be compensated for participating in this trial.
Who is running the clinical trial?
Media Library
- I have received an organ transplant.I have been diagnosed with mild cognitive impairment or dementia, including Alzheimer's.My cognitive function is good, with a MoCA score of 26 or higher.My cognitive function is good, with a MoCA score of 26 or higher.I have not had a heart attack, stroke, or specific serious health issues in the last 6 months.I have not taken immunosuppressant drugs in the last year.My gender or ethnicity does not limit my participation.I have chronic heart failure.I am taking blood thinners other than aspirin.I have a history of liver or kidney disease.I have had a ruptured brain aneurysm in the past.I have diabetes with HBA1c levels of 6.5% or higher, or I am on diabetes medication.My gender or ethnicity does not limit my participation.I carry one or two copies of the APOE4 gene.I carry one or two copies of the APOE4 gene.I have a brain lesion or abnormal brain pressure confirmed by MRI or CT.I do not have active inflammation, COVID-19, autoimmune diseases, infections, liver or severe digestive issues, cancer, or severe mental health conditions.I do not carry the APOE4 gene.I have had a stroke in the past.I have not had chemotherapy or radiation in the past year.I have had skin ulcers or issues with wounds not healing well.I am between 45 and 65 years old.My blood pressure is not higher than 160/100 mmHg.My cognitive function is good, with a MoCA score of 26 or higher.I am taking medications that interact with CYP3A4.I do not carry the APOE4 gene.I have a long-term lung condition.I am between 45 and 65 years old.My gender or ethnicity does not limit my participation.
- Group 1: Non-Carrier APOE4
- Group 2: Carrier APOE4
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Is the age range for this trial inclusive of septuagenarians?
"Per the requirements for enrolment in this trial, all participants must be between 45 and 65 years old."
Is it possible to participate in this scientific experiment?
"This medical trial seeks 105 patients with a genetic susceptibility to disease, falling within the 45 - 65 year old age bracket. Eligible participants must additionally meet the following criteria: 2. Denomination of sex and ethnicity; 4. A 0-rating on their Clinical Dementia Rating Staging Instrument; 5. Being an APOE4 homozygous or heterozygous carrier in case of the Carrier Cohort group; 3. Having Montreal Cognitive Assessment scores greater than 26 points; 6. No identification of APOE4 gene for those enrolled in Non-Carrier cohort group; 1. Age range between 45-65 years old"
Could you please elucidate the security of Sirolimus for human consumption?
"The safety of Sirolimus was rated a 1 on our scale, due to the limited data collected during Phase I trials which only demonstrate preliminary evidence for its efficacy and safety."
Is this study actively seeking participants?
"Current information hosted on clinicaltrials.gov displays that this medical trial is inactively searching for participants, with the original posting being 2/1/2023 and last update 10/31/2022. Although this study isn't actively recruiting at present, there are 874 other studies currently enrolling patients."
Who else is applying?
What state do they live in?
What site did they apply to?
What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Share this study with friends
Copy Link
Messenger