Virtual Heart Guided Ablation for Ventricular Tachycardia
(AVERT-VT Trial)
Trial Summary
Do I have to stop taking my current medications for this trial?
The trial protocol does not specify whether you need to stop taking your current medications. Please consult with the trial coordinators or your doctor for guidance.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the study team or your doctor.
What data supports the idea that Virtual Heart Guided Ablation for Ventricular Tachycardia is an effective treatment?
The available research shows that Virtual Heart Guided Ablation, which uses advanced mapping techniques to target areas of the heart causing ventricular tachycardia, has been effective in reducing the frequency of these episodes. For example, early studies using radiotherapy for ablation have shown a consistent decrease in the burden of ventricular tachycardia, indicating that this treatment can effectively manage the condition. Additionally, substrate-based approaches, which focus on targeting specific areas of the heart tissue, have been shown to improve outcomes compared to traditional methods. These findings suggest that Virtual Heart Guided Ablation is a promising treatment for ventricular tachycardia.12345
What data supports the effectiveness of the treatment Virtual Heart Guided Ablation for Ventricular Tachycardia?
Research shows that substrate-based ablation strategies, which are part of the Virtual Heart Guided Ablation treatment, have improved outcomes in treating ventricular tachycardia by targeting areas of the heart that cause irregular rhythms. Additionally, early studies on using radiotherapy for ablation have shown a consistent decrease in ventricular tachycardia episodes, suggesting potential effectiveness.12345
What safety data exists for Virtual Heart Guided Ablation for Ventricular Tachycardia?
The safety data for Virtual Heart Guided Ablation, also known as substrate-based ablation or electrophysiology-guided cardiac radioablation, includes several studies. MRI-guided VT ablation integrates 3D scar reconstruction to facilitate the procedure, which is used in patients with implantable cardioverter-defibrillators. Radiotherapy for VT ablation has shown a consistent decrease in VT burden with sufficient acute safety, though concerns about late effects on critical structures remain. Substrate-based ablation is a first-line treatment for VT in patients with structural heart disease, but recurrence is common. Stereotactic radioablation is a non-invasive option with promising short-term efficacy and tolerable side effects, though more detailed multicenter studies are needed to fully assess safety.23567
Is Virtual Heart Guided Ablation for Ventricular Tachycardia safe for humans?
Is Virtual Heart Guided Ablation a promising treatment for Ventricular Tachycardia?
How is Virtual Heart Guided Ablation different from other treatments for ventricular tachycardia?
Virtual Heart Guided Ablation is unique because it uses a virtual model of the heart to guide the ablation process, allowing for precise targeting of the heart tissue responsible for ventricular tachycardia. This approach can be more effective than traditional methods, especially when the arrhythmia is difficult to map or sustain during the procedure.12458
What is the purpose of this trial?
The goal of this study is to test the efficacy of the new imaging/simulation ("virtual heart") approach for determining the optimal ablation sites in patients with VT, which render post-infarction VT non-inducible. The study will test both the acute outcome of the ablation procedure, and the effect the use of the predicted targets has upon procedure time.
Research Team
Jonathan Chrispin, MD
Principal Investigator
Johns Hopkins University
Eligibility Criteria
This trial is for adults with a rapid heartbeat condition called Ventricular Tachycardia (VT) due to heart scarring. They must have had an MRI scan showing this scarring and be considered suitable for ablation therapy by their heart doctors. People with very poor kidney function, pregnant women, or those who can't undergo an MRI are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Ablation Procedure
Participants undergo the ablation procedure using the virtual heart approach to determine optimal ablation sites
Follow-up
Participants are monitored for safety and effectiveness after the ablation procedure
Treatment Details
Interventions
- Virtual Heart Guided Ablation
Virtual Heart Guided Ablation is already approved in United States, European Union for the following indications:
- Ventricular tachycardia (VT)
- Refractory ventricular tachycardia (VT)
Find a Clinic Near You
Who Is Running the Clinical Trial?
Johns Hopkins University
Lead Sponsor